{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:15:55Z","timestamp":1788243355099,"version":"build-2803163510"},"reference-count":45,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: Temporomandibular joint (TMJ) mobility disorders encompass opposing clinical problems, ranging from hypermobility, subluxation, and recurrent dislocation to restricted mandibular mobility caused by disc displacement without reduction (DDwoR). Dextrose-based injections have been investigated in both settings, although their therapeutic objectives may differ. This scoping review mapped the clinical indications, injection protocols, outcomes, safety findings, and evidence gaps. Methods: PubMed\/MEDLINE, Europe PMC, and BASE were searched from inception through 14 June 2026. Study selection and data charting were conducted independently by two reviewers, and primary studies underwent design-specific JBI appraisal. Results: Eighteen reports were included: 14 reports describing 13 primary clinical studies (two reports were companion publications from the same randomized pilot cohort) and four systematic reviews used for evidence mapping. Among the primary studies, twelve addressed excessive TMJ mobility, and one evaluated DDwoR with limited mouth opening. In hypermobility and recurrent dislocation, within-group reductions in pain, excessive mouth opening, and recurrence were commonly reported, but superiority over placebo or active comparators was inconsistent. In DDwoR, 5% dextrose was associated with improvements in pain, mouth opening, and chewing function, although the evidence was limited by the small sample. No serious adverse events were reported. Conclusions: Substantial heterogeneity precluded quantitative synthesis and prevented identification of an optimal protocol. Indication-specific, adequately powered randomized trials with standardized outcomes and longer follow-up are required.<\/jats:p>","DOI":"10.3390\/jcm15176708","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:45:13Z","timestamp":1788241513000},"page":"6708","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dextrose Injections Across Temporomandibular Joint Mobility Disorders: A Scoping Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Julia","family":"Kasprzycka","sequence":"first","affiliation":[{"name":"Miodowa Clinic, G\u0142owaccy Medical and Dental Practice Professional Partnership, Kiekrz, Miodowa 2, 62-090 Rokietnica, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6199-4753","authenticated-orcid":false,"given":"Maciej","family":"Ch\u0119ci\u0144ski","sequence":"additional","affiliation":[{"name":"National Medical Institute of the Ministry of the Interior and Administration, Wo\u0142oska 137, 02-507 Warsaw, Poland"},{"name":"Department of Maxillofacial Surgery, Hospital of the Ministry of the Interior and Administration, Wojska Polskiego 51, 25-375 Kielce, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2456-1355","authenticated-orcid":false,"given":"Justyna","family":"Wilk","sequence":"additional","affiliation":[{"name":"Ortosfera Orthodontic Practice, W\u0142adys\u0142awa Reymonta 2, 33-300 Nowy S\u0105cz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5580-8941","authenticated-orcid":false,"given":"Wojciech","family":"Macek","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Preventive Medicine Center, Komorowskiego 12, 30-106 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6747-1336","authenticated-orcid":false,"given":"Maja","family":"Kosi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Preventive Medicine Center, Komorowskiego 12, 30-106 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4345-5657","authenticated-orcid":false,"given":"Amelia","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Preventive Medicine Center, Komorowskiego 12, 30-106 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliwia","family":"Jagie\u0142\u0142o","sequence":"additional","affiliation":[{"name":"Gabinety Lekarskie Dent-im M.B. Pawelczyk Sp\u00f3\u0142ka Jawna, R\u00f3\u017cana 13\/1, 61-577 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Grzybowska-Kowalczyk","sequence":"additional","affiliation":[{"name":"U\u015bmiech Family Dental Clinic, Nastrojowa 26, 91-496 \u0141\u00f3d\u017a, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Horodniczy","sequence":"additional","affiliation":[{"name":"Ortho.pl Dental Office, Buforowa 34, 52-131 Wroc\u0142aw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-2009-3556","authenticated-orcid":false,"given":"Zuzanna","family":"Baniak","sequence":"additional","affiliation":[{"name":"Stomatologia Centrum, Moniuszki 3\/7, 32-020 Wieliczka, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izabella","family":"Chy\u017cy","sequence":"additional","affiliation":[{"name":"National Medical Institute of the Ministry of the Interior and Administration, Wo\u0142oska 137, 02-507 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Ch\u0119ci\u0144ska","sequence":"additional","affiliation":[{"name":"National Medical Institute of the Ministry of the Interior and Administration, Wo\u0142oska 137, 02-507 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3348-1950","authenticated-orcid":false,"given":"Maciej","family":"Sikora","sequence":"additional","affiliation":[{"name":"National Medical Institute of the Ministry of the Interior and Administration, Wo\u0142oska 137, 02-507 Warsaw, Poland"},{"name":"Department of Maxillofacial Surgery, Hospital of the Ministry of the Interior and Administration, Wojska Polskiego 51, 25-375 Kielce, Poland"},{"name":"Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powsta\u0144c\u00f3w Wielkopolskich 72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00784-020-03710-w","article-title":"Prevalence of temporomandibular joint disorders: A systematic review and meta-analysis","volume":"25","author":"Valesan","year":"2021","journal-title":"Clin. 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