{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T12:14:53Z","timestamp":1788437693040,"version":"build-2803163510"},"reference-count":67,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: Healthcare-associated infections (HAIs) frequently complicate aneurysmal subarachnoid hemorrhage (aSAH) requiring neurocritical care. We assessed their incidence, timing, microbiology, associated factors, and outcomes. Methods: This retrospective, single-center cohort study included 106 consecutive adults with acute aSAH admitted to a neurocritical care unit during 2019\u20132024. Time to first HAI was analyzed using cause-specific Cox regression with competing risks; to limit immortal-time bias, HAI was modeled as a time-dependent exposure in outcome analyses. Results: HAIs occurred in 47 patients (44.3%; 95% CI 35.2\u201353.8); median onset was 10 days (IQR 8\u201312). Seventy-six episodes were recorded; site-specific figures denote affected patients, with no recurrent same-site episodes: ventilator-associated pneumonia, 30 (28.3%); catheter-associated urinary tract infection, 24 (22.6%); cerebrospinal fluid infections, 13 (12.3%); and central line-associated bloodstream infection, 9 (8.5%). Acinetobacter baumannii predominated, accounting for all extensively drug-resistant isolates. High World Federation of Neurosurgical Societies grade was associated with the first HAI (HR 4.168; 95% CI 2.072\u20138.384), as was higher modified Fisher grade in sensitivity analysis (HR 2.886; 95% CI 1.237\u20136.735). Time-dependent HAI was associated with a lower hazard of live discharge (HR 0.295; 95% CI 0.164\u20130.529) but not with in-hospital mortality (HR 1.178; 95% CI 0.478\u20132.902). Its association with the discharge Glasgow Outcome Scale (GOS) was threshold-dependent (GOS \u2264 1: OR 0.715, 95% CI 0.264\u20131.933; GOS \u2264 3: OR 7.939, 95% CI 2.580\u201324.436). Conclusions: HAIs affected nearly half of this cohort. Greater initial severity was associated with a higher hazard of first HAI; HAI, in turn, was associated with prolonged hospitalization and unfavorable functional outcome, but not with mortality. These associations are observational, not causal. Surveillance, timely diagnosis, and infection prevention remain integral to neurocritical care in aSAH.<\/jats:p>","DOI":"10.3390\/jcm15176718","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:45:13Z","timestamp":1788241513000},"page":"6718","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Healthcare-Associated Infections After Aneurysmal Subarachnoid Hemorrhage: A Retrospective Single-Center Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0954-5483","authenticated-orcid":false,"given":"Aleksandra","family":"Kosikowska","sequence":"first","affiliation":[{"name":"Scientific Student Club, Department of Anesthesiology and Intensive Care, University Clinical Hospital in Wroclaw, 50-556 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2571-5399","authenticated-orcid":false,"given":"Aleksandra","family":"To\u0142kacz","sequence":"additional","affiliation":[{"name":"Scientific Student Club, Department of Anesthesiology and Intensive Care, University Clinical Hospital in Wroclaw, 50-556 Wroclaw, 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Poland"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"software","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5682-1092","authenticated-orcid":false,"given":"Jaros\u0142aw","family":"K\u0119dziora","sequence":"additional","affiliation":[{"name":"Clinical Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Wroclaw Medical University, 50-367 Wroclaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Waldemar","family":"Go\u017adzik","sequence":"additional","affiliation":[{"name":"Clinical Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Wroclaw Medical 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subarachnoid hemorrhage: A primer for acute care practitioners","volume":"26","author":"Heppner","year":"2025","journal-title":"J. Intensive Care Soc."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Chai, C.-Z., Ho, U.-C., and Kuo, L.-T. (2023). Systemic Inflammation after Aneurysmal Subarachnoid Hemorrhage. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241310943"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s10143-025-04007-w","article-title":"Clinical outcomes and complication risks of aneurysmal subarachnoid hemorrhage (aSAH) in high-altitude regions: A retrospective study from Xizang","volume":"49","author":"Cao","year":"2025","journal-title":"Neurosurg. Rev."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/s00134-024-07387-7","article-title":"Contemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist","volume":"50","author":"Robba","year":"2024","journal-title":"Intensive Care Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1113\/EP085560","article-title":"Interaction between the hypothalamus and the immune system","volume":"101","author":"Buijs","year":"2016","journal-title":"Exp. Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0031-6997(24)01470-4","article-title":"The sympathetic nerve\u2014An integrative interface between two supersystems: The brain and the immune system","volume":"52","author":"Elenkov","year":"2000","journal-title":"Pharmacol. Rev."},{"key":"ref_8","first-page":"346","article-title":"The impact of initial systemic inflammatory response after aneurysmal subarachnoid hemorrhage","volume":"27","author":"Zhong","year":"2017","journal-title":"Turk. Neurosurg."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Chaudhry, S.R., Kahlert, U.D., Kinfe, T.M., Lamprecht, A., Niemel\u00e4, M., H\u00e4nggi, D., and Muhammad, S. (2020). Elevated Systemic IL-10 Levels Indicate Immunodepression Leading to Nosocomial Infections after Aneurysmal Subarachnoid Hemorrhage (SAH) in Patients. Int. J. Mol. Sci., 21.","DOI":"10.3390\/ijms21051569"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"8309","DOI":"10.1038\/s41598-021-87863-y","article-title":"Multidrug-resistant organisms (MDROs) in patients with subarachnoid hemorrhage (SAH)","volume":"11","author":"Rhim","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1227\/neu.0000000000002676","article-title":"Perioperative Infection After Aneurysmal Subarachnoid Hemorrhage: Risk Factors, Causative Pathogens, and Long-Term Outcomes","volume":"94","author":"Kilgore","year":"2024","journal-title":"Neurosurgery"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1328729","DOI":"10.1155\/2022\/1328729","article-title":"Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment","volume":"2022","author":"Pan","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.3171\/2015.10.JNS151959","article-title":"Association of nosocomial infections with delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage","volume":"125","author":"Foreman","year":"2016","journal-title":"J. Neurosurg."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"McBride, D.W., Blackburn, S.L., Peeyush, K.T., Matsumura, K., and Zhang, J.H. (2017). The Role of Thromboinflammation in Delayed Cerebral Ischemia after Subarachnoid Hemorrhage. Front. Neurol., 8.","DOI":"10.3389\/fneur.2017.00555"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Kashiwazaki, D., Maruyama, K., Hamada, S., Yamamoto, S., Hori, E., Akioka, N., Noguchi, K., and Kuroda, S. (2025). Infection Associated with Global Cerebral Edema and Delayed Cerebral Ischemia in Patients with Aneurysmal Subarachnoid Hemorrhage. J. Clin. Med., 14.","DOI":"10.3390\/jcm14113808"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Centner, F.-S., Wenz, H., Oster, M.E., Dally, F.-J., Sauter-Servaes, J., Pelzer, T., Schoettler, J.J., Hahn, B., Abdulazim, A., and Hackenberg, K.A.M. (2024). Sepsis and delayed cerebral ischemia are associated and have a cumulative effect on poor functional outcome in aneurysmal subarachnoid hemorrhage. Front. Neurol., 15.","DOI":"10.3389\/fneur.2024.1393989"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1097\/ANA.0000000000000732","article-title":"Impact of Ventilator-associated Pneumonia on Cerebrospinal Fluid Inflammation During Immunosuppression After Subarachnoid Hemorrhage: A Pilot Study","volume":"34","author":"Coelembier","year":"2022","journal-title":"J. Neurosurg. Anesthesiol."},{"key":"ref_18","first-page":"e100861","article-title":"Bacteremia associated with delayed cerebral ischemia after interventional treatment of aneurysmal subarachnoid hemorrhage","volume":"18","author":"Irie","year":"2026","journal-title":"Cureus"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/ana.20611","article-title":"Validation of a new coma scale: The FOUR score","volume":"58","author":"Wijdicks","year":"2005","journal-title":"Ann. Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s12028-017-0396-5","article-title":"Predicting outcome in subarachnoid hemorrhage (SAH) utilizing the full outline of unresponsiveness (FOUR) score","volume":"27","author":"Zeiler","year":"2017","journal-title":"Neurocrit. Care"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000346087","article-title":"European Stroke Organization Guidelines for the Management of Intracranial Aneurysms and Subarachnoid Haemorrhage","volume":"35","author":"Steiner","year":"2013","journal-title":"Cerebrovasc. Dis."},{"key":"ref_22","first-page":"e314","article-title":"2023 guideline for the management of patients with aneurysmal subarachnoid hemorrhage: A guideline from the american heart association\/american stroke association","volume":"54","author":"Hoh","year":"2023","journal-title":"Stroke"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e549","DOI":"10.1016\/j.wneu.2022.08.044","article-title":"The Benefits and Feasibility of External Lumbar Cerebrospinal Fluid Drainage for Cerebral Vasospasm in Patients with Aneurysmal Subarachnoid Hemorrhage: Meta-Analysis and Trial Sequential Analysis","volume":"167","author":"Lee","year":"2022","journal-title":"World Neurosurg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.wneu.2022.07.061","article-title":"Lumbar Drainage After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Meta-Analysis","volume":"166","author":"Hulou","year":"2022","journal-title":"World Neurosurg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3171\/jns.2004.100.2.0215","article-title":"Marked reduction of cerebral vasospasm with lumbar drainage of cerebrospinal fluid after subarachnoid hemorrhage","volume":"100","author":"Klimo","year":"2004","journal-title":"J. Neurosurg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/STROKEAHA.111.625731","article-title":"Lumbar drainage of cerebrospinal fluid after aneurysmal subarachnoid hemorrhage: A prospective, randomized, controlled trial (LUMAS)","volume":"43","author":"Bhargava","year":"2012","journal-title":"Stroke"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4103\/1793-5482.228512","article-title":"Spinal Cerebrospinal Fluid Drainage for prevention of Vasospasm in Aneurysmal Subarachnoid Hemorrhage: A Prospective, Randomized controlled study","volume":"13","author":"Borkar","year":"2018","journal-title":"Asian J. Neurosurg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1161\/STROKEAHA.119.025399","article-title":"Prospective trial of cerebrospinal fluid filtration after aneurysmal subarachnoid hemorrhage via lumbar catheter (PILLAR)","volume":"50","author":"Blackburn","year":"2019","journal-title":"Stroke"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1001\/jamaneurol.2023.1792","article-title":"Effectiveness of lumbar cerebrospinal fluid drain among patients with aneurysmal subarachnoid hemorrhage: A randomized clinical trial","volume":"80","author":"Wolf","year":"2023","journal-title":"JAMA Neurol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1097\/CCM.0000000000003297","article-title":"Transcranial Doppler in the Diagnosis of Cerebral Vasospasm: An Updated Meta-Analysis","volume":"46","author":"Mastantuono","year":"2018","journal-title":"Crit. Care Med."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Merkel, H., Lindner, D., Gaber, K., Ziganshyna, S., Jentzsch, J., Mucha, S., Gerhards, T., Sari, S., Stock, A., and Vothel, F. (2022). Standardized Classification of Cerebral Vasospasm after Subarachnoid Hemorrhage by Digital Subtraction Angiography. J. Clin. Med., 11.","DOI":"10.3390\/jcm11072011"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1161\/STROKEAHA.110.589275","article-title":"Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: Proposal of a multidisciplinary research group","volume":"41","author":"Vergouwen","year":"2010","journal-title":"Stroke"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0261-5614(03)00098-0","article-title":"ESPEN guidelines for nutrition screening 2002","volume":"22","author":"Kondrup","year":"2003","journal-title":"Clin. Nutr."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1164\/rccm.2107138","article-title":"The Richmond Agitation-Sedation Scale: Validity and reliability in adult intensive care unit patients","volume":"166","author":"Sessler","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_35","unstructured":"European Centre for Disease Prevention and Control (2017, June 13). European Surveillance of Healthcare-Associated Infections in Intensive Care Units\u2014HAI-Net ICU Protocol, Version 1.02, Available online: https:\/\/www.ecdc.europa.eu\/sites\/default\/files\/media\/en\/publications\/Publications\/healthcare-associated-infections-HAI-ICU-protocol.pdf."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1093\/cid\/ciw861","article-title":"2017 Infectious Diseases Society of America\u2019s Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis","volume":"64","author":"Tunkel","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s12028-015-0224-8","article-title":"The Insertion and Management of External Ventricular Drains: An Evidence-Based Consensus Statement: A Statement for Healthcare Professionals from the Neurocritical Care Society","volume":"24","author":"Fried","year":"2016","journal-title":"Neurocrit. Care"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1017\/ice.2023.138","article-title":"Executive Summary: A Compendium of Strategies to Prevent Healthcare-Associated Infections in Acute-Care Hospitals: 2022 Updates","volume":"44","author":"Yokoe","year":"2023","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_39","unstructured":"European Centre for Disease Prevention and Control (2017). European Surveillance of Healthcare Associated Infections in Intensive Care Units\u2014HAI-Net ICU Protocol, Version 2.2, ECDC. Available online: https:\/\/www.ecdc.europa.eu\/sites\/default\/files\/documents\/HAI-Net-ICU-protocol-v2.2_0.pdf."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"De Pascale, G., Ranzani, O.T., Nseir, S., Chastre, J., Welte, T., Antonelli, M., Navalesi, P., Garofalo, E., Bruni, A., and Coelho, L.M. (2017). Intensive care unit patients with lower respiratory tract nosocomial infections: The ENIRRIs project. ERJ Open Res., 3.","DOI":"10.1183\/23120541.00092-2017"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1468-1331.2006.01493.x","article-title":"Guidelines on routine cerebrospinal fluid analysis. Report from an EFNS task force","volume":"13","author":"Deisenhammer","year":"2006","journal-title":"Eur. J. Neurol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1086\/425368","article-title":"Practice guidelines for the management of bacterial meningitis","volume":"39","author":"Tunkel","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"ref_43","unstructured":"European Committee on Antimicrobial Susceptibility Testing (EUCAST) (2026, August 07). Breakpoint Tables for Interpretation of MICs and Zone Diameters. Available online: https:\/\/www.eucast.org\/bacteria\/clinical-breakpoints-and-interpretation\/clinical-breakpoint-tables\/."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: An international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Jennett, B., Teasdale, G., and Knill-Jones, R. (1975). Prognosis after severe head injury. Ciba Foundation Symposium 34\u2014Outcome of Severe Damage to the Central Nervous System, Elsevier.","DOI":"10.1002\/9780470720165.ch18"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1111\/ijs.12494","article-title":"Nosocomial infections after aneurysmal subarachnoid hemorrhage: Time course and causative pathogens","volume":"10","author":"Laban","year":"2015","journal-title":"Int. J. Stroke"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.wneu.2015.10.054","article-title":"Hospital-Acquired Infections after Aneurysmal Subarachnoid Hemorrhage: A Nationwide Analysis","volume":"88","author":"Dasenbrock","year":"2016","journal-title":"World Neurosurg."},{"key":"ref_48","unstructured":"European Centre for Disease Prevention and Control (2019). Healthcare-Associated Infections Acquired in Intensive Care Units. ECDC Annual Epidemiological Report for 2017, ECDC. Available online: https:\/\/www.ecdc.europa.eu\/en\/publications-data\/healthcare-associated-infections-intensive-care-units-annual-epidemiological-1."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Wa\u0142aszek, M., R\u00f3\u017ca\u0144ska, A., Wa\u0142aszek, M.Z., W\u00f3jkowska-Mach, J., and Polish Society of Hospital Infections Team (2018). Epidemiology of Ventilator-Associated Pneumonia, microbiological diagnostics and the length of antimicrobial treatment in the Polish Intensive Care Units in the years 2013\u20132015. BMC Infect. Dis., 18.","DOI":"10.1186\/s12879-018-3212-8"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Duszynska, W., Rosenthal, V.D., Szczesny, A., Zajaczkowska, K., Fulek, M., and Tomaszewski, J. (2020). Device associated -health care associated infections monitoring, prevention and cost assessment at intensive care unit of University Hospital in Poland (2015\u20132017). BMC Infect. Dis., 20.","DOI":"10.1186\/s12879-020-05482-w"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1017\/ice.2016.174","article-title":"Antimicrobial-Resistant Pathogens Associated With Healthcare-Associated Infections: Summary of Data Reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2011\u20132014","volume":"37","author":"Weiner","year":"2016","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Chmielarczyk, A., Pomorska-Weso\u0142owska, M., Romaniszyn, D., and W\u00f3jkowska-Mach, J. (2021). Healthcare-Associated Laboratory-Confirmed Bloodstream Infections-Species Diversity and Resistance Mechanisms, a Four-Year Retrospective Laboratory-Based Study in the South of Poland. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18052785"},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Sleziak, J., B\u0142a\u017cejewska, M., and Duszy\u0144ska, W. (2025). Central Line-Associated Bloodstream Infections in Intensive Care Unit During and After the COVID-19 Pandemic, 5-Year Prospective Observational Study. J. Clin. Med., 14.","DOI":"10.3390\/jcm14165655"},{"key":"ref_54","unstructured":"Centers for Disease Control and Prevention (2026, August 10). HAI Pathogens and Antimicrobial Resistance Report, 2018\u20132021, Available online: https:\/\/www.cdc.gov\/\/nhsn\/hai-report\/index.html."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"6228","DOI":"10.1038\/s41598-020-63298-9","article-title":"Impact of Complications and Comorbidities on the Intensive Care Length of Stay after Aneurysmal Subarachnoid Haemorrhage","volume":"10","author":"Hammer","year":"2020","journal-title":"Sci. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Chaudhry, S.R., Hafez, A., Rezai Jahromi, B., Kinfe, T.M., Lamprecht, A., Niemel\u00e4, M., and Muhammad, S. (2018). Role of damage associated molecular pattern molecules (damps) in aneurysmal subarachnoid hemorrhage (asah). Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19072035"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Chaudhry, S.R., Stoffel-Wagner, B., Kinfe, T.M., G\u00fcresir, E., Vatter, H., Dietrich, D., Lamprecht, A., and Muhammad, S. (2017). Elevated Systemic IL-6 Levels in Patients with Aneurysmal Subarachnoid Hemorrhage Is an Unspecific Marker for Post-SAH Complications. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122580"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s12028-008-9054-2","article-title":"The burden of the systemic inflammatory response predicts vasospasm and outcome after subarachnoid hemorrhage","volume":"8","author":"Dhar","year":"2008","journal-title":"Neurocrit. Care"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1080\/01616412.2025.2482755","article-title":"Clinical presentations of post ischemic and post traumatic brain injury scars associated seizures","volume":"47","author":"Chavda","year":"2025","journal-title":"Neurol. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/epi.13778","article-title":"Neuroinflammation imaging markers for epileptogenesis","volume":"58","author":"Koepp","year":"2017","journal-title":"Epilepsia"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nrn1765","article-title":"Central nervous system injury-induced immune deficiency syndrome","volume":"6","author":"Meisel","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1161\/01.STR.0000251441.89665.bc","article-title":"Stroke-induced immunodepression: Experimental evidence and clinical relevance","volume":"38","author":"Dirnagl","year":"2007","journal-title":"Stroke"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1172\/JCI135530","article-title":"Immune responses to stroke: Mechanisms, modulation, and therapeutic potential","volume":"130","author":"Iadecola","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1212\/01.wnl.0000258543.45879.f5","article-title":"Fever after subarachnoid hemorrhage: Risk factors and impact on outcome","volume":"68","author":"Fernandez","year":"2007","journal-title":"Neurology"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1136\/jnnp.2006.112730","article-title":"Non-infectious fever in the neurological intensive care unit: Incidence, causes and predictors","volume":"78","author":"Rabinstein","year":"2007","journal-title":"J. Neurol. Neurosurg. Psychiatr."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12931-023-02456-9","article-title":"Ventilator-associated pneumonia in neurocritically ill patients: Insights from the ENIO international prospective observational study","volume":"24","author":"Battaglini","year":"2023","journal-title":"Respir. Res."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Ramanan, M., Lipman, J., Shorr, A., and Shankar, A. (2015). A meta-analysis of ventriculostomy-associated cerebrospinal fluid infections. BMC Infect. Dis., 15.","DOI":"10.1186\/s12879-014-0712-z"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/17\/6718\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:27:06Z","timestamp":1788434826000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/17\/6718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,29]]},"references-count":67,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["jcm15176718"],"URL":"https:\/\/doi.org\/10.3390\/jcm15176718","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,29]]}}}