{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:15:59Z","timestamp":1788243359488,"version":"build-2803163510"},"reference-count":71,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T00:00:00Z","timestamp":1787961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Graduate Studies and Scientific Research at Najran University","award":["NU\/GP\/MRC\/14\/3166-1"],"award-info":[{"award-number":["NU\/GP\/MRC\/14\/3166-1"]}]},{"award":["NU\/GP\/MRC\/14\/3166-1"],"award-info":[{"award-number":["NU\/GP\/MRC\/14\/3166-1"]}],"id":[{"id":"https:\/\/ror.org\/05edw4a90","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: Preoperative risk stratification in renal cell carcinoma (RCC) remains challenging for tumor aggressiveness and for adherent perinephric fat (APF) relevant to surgical planning. Although intratumoral radiomics are established, the peritumoral and perirenal fat microenvironment is biologically active and may encode imaging biomarkers. This systematic review and meta-analysis evaluated CT-based peritumoral and perirenal fat radiomics for preoperative grading, staging, and APF prediction and examined whether fat-derived features add incremental value beyond intratumoral models. Methods: Following PRISMA 2020 and a registered protocol (PROSPERO CRD420251150155), databases were searched through March 2026, with documented verification searches through August 2026. Eligible studies extracted CT radiomics from peritumoral or perirenal fat in adults with RCC and reported discrimination metrics. Random-effects meta-analyses (restricted maximum likelihood with Hartung\u2013Knapp intervals) were performed; incremental value was estimated from nested within-study AUC differences under predefined rules; and methodological quality was assessed with PROBAST, RQS, METRICS, and TRIPOD, and certainty with an adapted GRADE framework. Results: Twenty-five retrospective studies (10,761 patients) were included. Fat radiomics were most consistent for APF prediction (pooled AUC 0.848, 95% CI 0.738\u20130.917; I2 = 0%). Pooled AUCs were 0.772 (0.599\u20130.884; I2 = 93%; 95% prediction interval 0.298\u20130.964) for grade and 0.813 (0.681\u20130.899; I2 = 72%) for stage. Combined fat-plus-tumor models were numerically higher than tumor-only models in 12 of 15 studies (exploratory p = 0.022), but the formally estimable nested increment (stage family, five studies) was small (delta-AUC +0.017; governing modified Hartung\u2013Knapp 95% CI \u22120.008 to +0.042) and statistically compatible with no true difference; fat-only models showed no evidence of differing from tumor-only models. PROBAST rated 72% of studies at high risk of bias, and 88% originated from China. Certainty ranged from VERY LOW (grade prediction; grade-family fat-versus-tumor comparison) to LOW (all remaining outcomes). Conclusions: CT-based peritumoral and perirenal fat radiomics show the most consistent signal for APF prediction, while the measurable increment from adding fat features to tumor models is small and of unestablished clinical utility. Standardized fat segmentation, calibration and decision-curve reporting and prospective multicenter validation are required before clinical translation.<\/jats:p>","DOI":"10.3390\/jcm15176720","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:45:13Z","timestamp":1788241513000},"page":"6720","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["CT-Based Peritumoral and Perirenal Fat Radiomics in Renal Cell Carcinoma: A Systematic Review and Meta-Analysis of Grade, Stage, and Adherent Perinephric Fat Prediction"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6513-4795","authenticated-orcid":false,"given":"Abdulrahman","family":"Al Mopti","sequence":"first","affiliation":[{"name":"Department of Radiological Sciences, College of Applied Medical Sciences, Najran University, Najran 55461, Saudi Arabia"},{"name":"Health Research Center, Najran University, Najran 55461, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6268-2574","authenticated-orcid":false,"given":"Ali H. D.","family":"Alshehri","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, College of Applied Medical Sciences, Najran University, Najran 55461, Saudi Arabia"},{"name":"Health Research Center, Najran University, Najran 55461, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulsalam","family":"Alqahtani","sequence":"additional","affiliation":[{"name":"Department of Radiological Sciences, College of Applied Medical Sciences, Najran University, Najran 55461, Saudi Arabia"},{"name":"Health Research Center, Najran University, Najran 55461, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,29]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. 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