{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:23:24Z","timestamp":1788265404263,"version":"build-2803163510"},"reference-count":30,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["ORF-2026-647"],"award-info":[{"award-number":["ORF-2026-647"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]},{"award":["ORF-2026-647"],"award-info":[{"award-number":["ORF-2026-647"]}],"id":[{"id":"https:\/\/ror.org\/02f81g417","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: Type 2 diabetes mellitus (T2DM) is increasingly recognised as a risk factor for physical frailty, driven by sarcopenia, microvascular disease, and chronic hyperglycaemia. Simple, low-cost performance tests may offer a practical means of identifying frailty risk in this population, but data combining several such measures in T2DM remain limited. This study aimed to characterise physical performance and quantify the proportion of adults with T2DM meeting thresholds for low physical performance. Methods: In this cross-sectional study, physical performance was assessed in adults with T2DM using the Timed Up and Go (TUG) test, handgrip strength (HGS), and the six-minute walk distance (6MWD). TUG cutoffs of 8 and 10 s were applied as exploratory external reference thresholds, consistent with cutoffs previously applied in chronic disease and older-adult populations. Results: Participants had a mean age of 55.6 \u00b1 4.8 years; 42 (64.6%) were male, and mean BMI was 29.6 \u00b1 4.4 kg\/m2. Mean TUG time was 9.30 \u00b1 3.02 s, right and left HGS were 30.8 \u00b1 10.1 kg and 28.0 \u00b1 9.3 kg, and mean 6MWD was 401.2 \u00b1 96.3 m. Forty-four participants (67.7%; 95% CI 55.6\u201377.8) exceeded the 8 s threshold, and 16 (24.6%; 95% CI 15.8\u201336.3) exceeded 10 s. TUG correlated strongly and inversely with 6MWD (r = \u22120.75, 95% CI \u22120.84 to \u22120.61; p &lt; 0.001). This remained unchanged after adjustment for age, sex, and BMI (r = \u22120.76) and held within men (r = \u22120.79) and women (r = \u22120.78) separately. Handgrip strength correlated with 6MWD (right r = 0.40; left r = 0.39; both p \u2264 0.001) and attenuated to non-significance after adjustment for sex (r = 0.22, p = 0.076) and for age, sex, and BMI (r = 0.18, p = 0.16). In multivariable regression, TUG was independently associated with 6MWD (\u221221.4 m per second, p &lt; 0.001), whereas handgrip strength was not (p = 0.064). Conclusions: A substantial proportion of adults with T2DM in this cohort displayed low-physical-performance profiles. Simple performance batteries combining TUG, handgrip strength, and 6MWD warrant further study as a potential means of identifying patients with T2DM who could benefit from targeted rehabilitation.<\/jats:p>","DOI":"10.3390\/jcm15176787","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:33:32Z","timestamp":1788262412000},"page":"6787","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["TUG-Defined Mobility Impairment and Physical Performance in Adults with Type 2 Diabetes Mellitus"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6317-6124","authenticated-orcid":false,"given":"Madawi","family":"Aljawaee","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Neah","family":"Albasha","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8845-109X","authenticated-orcid":false,"given":"Rakan I.","family":"Nazer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Sciences, College of Medicine, King Saud University, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0554-8721","authenticated-orcid":false,"given":"Ali M.","family":"Albarrati","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s13410-022-01092-1","article-title":"National and Regional Prevalence Rates of Diabetes in Saudi Arabia: Analysis of National Survey Data","volume":"43","author":"Alqahtani","year":"2023","journal-title":"Int. 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