{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:24:55Z","timestamp":1788341095924,"version":"build-2803163510"},"reference-count":47,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy of Craiova, Romania"},{"id":[{"id":"https:\/\/ror.org\/031d5vw30","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background: Spermatocytic tumor (ST) is a rare non-GCNIS-derived testicular germ cell neoplasm that predominantly affects older men and generally follows an indolent course. Its occurrence in a cryptorchid testis is exceptionally uncommon. Methods: A narrative literature review was conducted using the PubMed database, including studies published up to August 2026. The search used combinations of the terms \u201cspermatocytic tumor\u201d, \u201cspermatocytic seminoma\u201d, \u201ccryptorchidism\u201d, \u201cundescended testis\u201d, \u201cimmunohistochemistry\u201d, \u201cmolecular features\u201d, \u201cmagnetic resonance imaging\u201d, and \u201ctreatment\u201d. Results: A 56-year-old man presented with a painless left inguinal mass corresponding to a cryptorchid testis. Serum tumor markers were normal. MRI demonstrated a well-circumscribed heterogeneous lesion with pseudocystic areas and enhancement of the solid component. Radical inguinal orchiectomy was performed. Histopathological examination revealed the characteristic triphasic cellular population without GCNIS, lymphovascular invasion, or sarcomatous transformation. Immunohistochemistry showed SALL4 and CD117 positivity and absence of OCT3\/4 and D2-40 expression, supporting the diagnosis of ST and its distinction from classical seminoma. No recurrence or metastatic disease was detected during 12 months of follow-up. Conclusions: ST arising in a cryptorchid testis represents an exceptionally uncommon presentation. Integration of clinical, radiological, morphological, and immunohistochemical findings is essential for accurate diagnosis and distinction from classical seminoma, thereby avoiding unnecessary additional treatment.<\/jats:p>","DOI":"10.3390\/jcm15176797","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:56:01Z","timestamp":1788339361000},"page":"6797","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spermatocytic Tumor Arising in a Cryptorchid Testis: A Case Report and Narrative Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5822-8805","authenticated-orcid":false,"given":"Lauren\u021biu Augustus","family":"Barbu","sequence":"first","affiliation":[{"name":"Department of Surgery, Railway Clinical Hospital Craiova, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stelian-Stefani\u021b\u0103","family":"Mogoant\u0103","sequence":"additional","affiliation":[{"name":"Department of Surgery, Emergency County Hospital, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8232-3457","authenticated-orcid":false,"given":"Liliana","family":"Cercelaru","sequence":"additional","affiliation":[{"name":"Department of Embryology and Anatomy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9672-1281","authenticated-orcid":false,"given":"Marius Cristian","family":"Marina\u0219","sequence":"additional","affiliation":[{"name":"Department of Embryology and Anatomy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolae-Drago\u0219","family":"M\u0103rg\u0103ritescu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Emergency County Hospital, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Popescu","sequence":"additional","affiliation":[{"name":"Imaging Department, University of Medicine and Pharmacy, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"C\u0103luianu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Railway Clinical Hospital Craiova, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Florin R\u0103zvan","family":"Mogo\u0219","sequence":"additional","affiliation":[{"name":"Department of Surgery, Railway Clinical Hospital Craiova, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7018-5675","authenticated-orcid":false,"given":"Liviu","family":"Vasile","sequence":"additional","affiliation":[{"name":"Department of Surgery, Emergency County Hospital, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiberiu Stef\u0103ni\u021b\u0103","family":"\u021aenea Cojan","sequence":"additional","affiliation":[{"name":"Department of Surgery, Railway Clinical Hospital Craiova, University of Medicine and Pharmacy of Craiova, 2 Petru Rares Street, 200349 Craiova, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1148\/rg.2017160164","article-title":"Testicular Seminoma and Its Mimics: From the Radiologic Pathology Archives","volume":"37","author":"Marko","year":"2017","journal-title":"Radiographics"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Secondino, S., Viglio, A., Neri, G., Galli, G., Faverio, C., Mascaro, F., Naspro, R., Rosti, G., and Pedrazzoli, P. (2023). Spermatocytic Tumor: A Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24119529"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3892\/mi.2023.111","article-title":"Spermatocytic tumor of the testis: A case report and mini review of the literature","volume":"3","author":"Bapir","year":"2023","journal-title":"Med. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/his.13102","article-title":"Members of the ISUP Testicular Tumour Panel. The World Health Organization 2016 classification of testicular germ cell tumours: A review and update from the International Society of Urological Pathology Testis Consultation Panel","volume":"70","author":"Williamson","year":"2017","journal-title":"Histopathology"},{"key":"ref_5","first-page":"3","article-title":"News in the classification of WHO 2022 testicular tumours","volume":"115","author":"Colecchia","year":"2022","journal-title":"Pathologica"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"722","DOI":"10.29271\/jcpsp.2021.06.722","article-title":"Spermatocytic Tumor of Testis in a Young Male","volume":"31","author":"Qureshi","year":"2021","journal-title":"J. Coll. Physicians Surg. Pak."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1177\/10668969221122995","article-title":"Sarcomatoid Spermatocytic Tumour: Report of a Rare Case and Literature Review","volume":"31","author":"Dias","year":"2023","journal-title":"Int. J. Surg. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.juro.2007.03.024","article-title":"Population based incidence and age distribution of spermatocytic seminoma","volume":"178","author":"Baade","year":"2007","journal-title":"J. Urol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/PAS.0000000000001001","article-title":"Spermatocytic Seminoma: A Report of 85 Cases Emphasizing Its Morphologic Spectrum Including Some Aspects Not Widely Known","volume":"43","author":"Hu","year":"2019","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e0021","DOI":"10.5041\/RMMJ.10155","article-title":"Spermatocytic variant of classic seminoma: A report of five cases and a brief review of the literature","volume":"5","author":"Stein","year":"2014","journal-title":"Rambam Maimonides Med. J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"11115","DOI":"10.12998\/wjcc.v9.i35.11115","article-title":"Spermatocytic tumor: A rare case report","volume":"9","author":"Hao","year":"2021","journal-title":"World J. Clin. Cases"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1016\/j.radcr.2023.07.043","article-title":"Spermatocytic tumors in 2 patients aged 50 and 77 years: 2 case reports and brief review of the literature","volume":"18","author":"Petersen","year":"2023","journal-title":"Radiol. Case Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/iju5.70089","article-title":"A Case of Spermatocytic Tumor of Testis","volume":"8","author":"Nagamine","year":"2025","journal-title":"IJU Case Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1001\/jama.2024.27122","article-title":"Testicular Germ Cell Tumors: A Review","volume":"333","author":"Singla","year":"2025","journal-title":"JAMA"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Banks, K., Tuazon, E., Berhane, K., Koh, C.J., De Filippo, R.E., Chang, A., Kim, S.S., Daneshmand, S., Davis-Dao, C., and Lewinger, J.P. (2013). Cryptorchidism and testicular germ cell tumors: Comprehensive meta-analysis reveals that association between these conditions diminished over time and is modified by clinical characteristics. Front. Endocrinol., 3.","DOI":"10.3389\/fendo.2012.00182"},{"key":"ref_16","first-page":"e44185","article-title":"A Case of Testicular Tumor Presenting as Acute Scrotum","volume":"15","author":"Alturaiki","year":"2023","journal-title":"Cureus"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/his.70040","article-title":"Molecular pathology of testicular germ cell tumours: An update for practicing pathologists","volume":"88","author":"Fichtner","year":"2026","journal-title":"Histopathology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/path.6210","article-title":"Genomic analysis of spermatocytic tumors demonstrates recurrent molecular alterations in cases with malignant clinical behavior","volume":"262","author":"Gupta","year":"2024","journal-title":"J. Pathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e66","DOI":"10.1097\/PAS.0000000000001465","article-title":"Report from the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers: IV: Current and Future Utilization of Molecular-Genetic Tests for Testicular Germ Cell Tumors","volume":"44","author":"Looijenga","year":"2020","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Chen, J., Mou, X., Zhang, Z., Zhang, W., Nie, Z., Gao, X., Gao, Y., and Qiu, J. (2025). Spermatocytic tumor associated with metastases: Report of a rare case and literature review. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1636142"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Giannoulatou, E., Maher, G.J., Ding, Z., Gillis, A.J.M., Dorssers, L.C.J., Hoischen, A., Meyts, E.R.-D., Consortium, W., McVean, G., and Wilkie, A.O.M. (2017). Whole-genome sequencing of spermatocytic tumors provides insights into the mutational processes operating in the male germline. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0178169"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1158\/0008-5472.CAN-05-2936","article-title":"Genomic and expression profiling of human spermatocytic seminomas: Primary spermatocyte as tumorigenic precursor and DMRT1 as candidate chromosome 9 gene","volume":"66","author":"Looijenga","year":"2006","journal-title":"Cancer Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/ng.470","article-title":"Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors","volume":"41","author":"Goriely","year":"2009","journal-title":"Nat. Genet."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Ghirardelli Smith, O.C., Tsai, A.K., Zhong, M., Dejban, P., Nelson, A.C., Dolan, M., Antonarakis, E.S., and Murugan, P. (2025). Case Report: Prepubertal-type testicular teratoma with local metastasis in a postpubertal patient. Front Oncol., 15.","DOI":"10.3389\/fonc.2025.1547258"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1007\/s00432-019-03056-1","article-title":"A systematic review of treatment outcomes in localised and metastatic spermatocytic tumors of the testis","volume":"145","author":"Grogg","year":"2019","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"5030349","DOI":"10.1155\/2019\/5030349","article-title":"Serum Tumour Markers in Testicular Germ Cell Tumours: Frequencies of Elevated Levels and Extents of Marker Elevation Are Significantly Associated with Clinical Parameters and with Response to Treatment","volume":"2019","author":"Dieckmann","year":"2019","journal-title":"BioMed Res. Int."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Katsimperis, S., Tzelves, L., Julieb\u00f8-Jones, P., and Skolarikos, A. (2026). Circulating MicroRNAs in Testicular Germ Cell Tumors: Biomarkers for Diagnosis, Surveillance, and Treatment Stratification. J. Pers. Med., 16.","DOI":"10.3390\/jpm16080400"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Tufano, A., Flammia, R.S., Antonelli, L., Minelli, R., Franco, G., Leonardo, C., and Cantisani, V. (2021). The Value of Contrast-Enhanced Ultrasound (CEUS) in Differentiating Testicular Masses: A Systematic Review and Meta-Analysis. Appl. Sci., 11.","DOI":"10.3390\/app11198990"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"480","DOI":"10.2967\/jnumed.107.047787","article-title":"Recommendations on the use of 18F-FDG PET in oncology","volume":"49","author":"Fletcher","year":"2008","journal-title":"J. Nucl. Med."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.path.2015.07.007","article-title":"Tumors of the Testis: Morphologic Features and Molecular Alterations","volume":"8","author":"Howitt","year":"2015","journal-title":"Surg. Pathol. Clin."},{"key":"ref_31","first-page":"2350","article-title":"Spermatocytic seminoma: A 21 years\u2019 retrospective study in a tertiary care hospital in Pakistan","volume":"6","author":"Haroon","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Surer, L., Kraft, P., Heiniger, Y., Abo Youssef, N., Bihl, M., John, H., and Bode, P. (2025). Spermatocytic tumor coexisting with a contralateral inguinoscrotal undifferentiated sarcoma: A case report. BMC Urol., 25.","DOI":"10.1186\/s12894-025-01770-2"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1097\/PAS.0000000000000116","article-title":"SALL4 expression in germ cell and non-germ cell tumors: A systematic immunohistochemical study of 3215 cases","volume":"38","author":"Miettinen","year":"2014","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.humpath.2022.07.020","article-title":"An update on diagnostic tissue-based biomarkers in testicular tumors","volume":"133","author":"Siegmund","year":"2023","journal-title":"Hum. Pathol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.stem.2018.08.007","article-title":"Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis","volume":"23","author":"Wang","year":"2018","journal-title":"Cell Stem Cell"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1053\/j.semdp.2022.07.001","article-title":"Germ cell neoplasms of the testis: Update for 2022","volume":"40","author":"Iczkowski","year":"2023","journal-title":"Semin Diagn. Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1016\/j.humpath.2007.03.011","article-title":"The Y-encoded TSPY protein: A significant marker potentially plays a role in the pathogenesis of testicular germ cell tumors","volume":"38","author":"Li","year":"2007","journal-title":"Hum. Pathol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.humpath.2015.09.028","article-title":"The utility of CDX2, GATA3, and DOG1 in the diagnosis of testicular neoplasms: An immunohistochemical study of 109 cases","volume":"48","author":"Osman","year":"2016","journal-title":"Hum. Pathol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3892\/etm.2013.1091","article-title":"Primary testicular diffuse large B-cell lymphoma: A case report focusing on touch imprint cytology and a non-germinal center B-cell-like phenotype","volume":"6","author":"Kim","year":"2013","journal-title":"Exp. Ther. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/CU9.0000000000000137","article-title":"Primary testicular lymphoma: Clinical characteristics and oncological outcomes","volume":"17","author":"Medina","year":"2023","journal-title":"Curr. Urol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"100368","DOI":"10.1016\/j.modpat.2023.100368","article-title":"Testicular Neoplasms with Sex Cord and Stromal Components Harbor a Recurrent Pattern of Chromosomal Gains","volume":"37","author":"Acosta","year":"2024","journal-title":"Mod. Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.21037\/tau.2019.12.20","article-title":"Radical inguinal orchidectomy: The gold standard for initial management of testicular cancer","volume":"9","author":"Koschel","year":"2020","journal-title":"Transl. Androl. Urol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"104712","DOI":"10.1016\/j.canrad.2025.104712","article-title":"Role of radiotherapy in the management of testicular cancer: Recommendations from the French society for radiation oncology","volume":"29","author":"Raynaud","year":"2025","journal-title":"Cancer Radiother."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00432-021-03890-2","article-title":"Treatment and follow-up of rare testis tumours","volume":"148","author":"Fankhauser","year":"2022","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Barbu, L.A., Cercelaru, L., \u0218urlin, V., Mogoant\u0103, S.-S., \u021aenea Cojan, T.S., M\u0103rg\u0103ritescu, N.-D., \u021aenea Cojan, A.-M., Popescu, M., C\u0103luianu, V., and Mogo\u0219, G.F.R. (2025). Serous Papillary Adenofibroma Cyst of the Ovary in a Young Woman: Case Report and Literature Review. Life, 15.","DOI":"10.3390\/life15101601"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"19","DOI":"10.47162\/RJME.67.1.02","article-title":"Primary cutaneous extraskeletal Ewing sarcoma of the plantar region: Clinicopathological features and review of the literature","volume":"67","author":"Barbu","year":"2026","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.2217\/fon.09.116","article-title":"Etiologic factors in testicular germ-cell tumors","volume":"5","author":"McGlynn","year":"2009","journal-title":"Future Oncol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/17\/6797\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:11:38Z","timestamp":1788340298000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/17\/6797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,2]]},"references-count":47,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["jcm15176797"],"URL":"https:\/\/doi.org\/10.3390\/jcm15176797","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,2]]}}}