{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:10:03Z","timestamp":1788786603058,"version":"build-2803163510"},"reference-count":36,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background: Abdominoplasty is associated with postoperative bleeding, drainage, and seroma. Methods: We searched four databases from inception through 16 May 2026 for randomized and non-randomized comparative studies of systemic or topical tranexamic acid (TXA). Results: Seven studies (one randomized controlled trial and six observational studies) reported 763 participants across source cohorts; treatment-arm assignment was available for 753. Random-effects meta-analysis associated TXA with lower total drainage volume (MD: \u2212233.32 mL, 95% CI: \u2212351.43 to \u2212115.21), shorter drainage time (MD: \u22121.36 days, 95% CI: \u22121.75 to \u22120.97), shorter hospital stay (MD: \u22121.48 days, 95% CI: \u22122.16 to \u22120.80), smaller absolute hemoglobin drop (MD: \u22120.87 g\/dL, 95% CI: \u22121.72 to \u22120.02), and lower seroma odds (OR: 0.51, 95% CI: 0.27 to 0.96). No significant differences were observed for 24 h drainage, relative hemoglobin drop, hematoma, surgical-site infection, wound-healing disorder, or transfusion. Rare adverse events were insufficiently reported. The absolute-hemoglobin and seroma associations were not robust to leave-one-out analysis, and major Doi-plot asymmetry affected several outcomes. Conclusions: TXA may improve selected early outcomes, but the small, mainly observational evidence base supports cautious individualized use rather than a universal regimen.<\/jats:p>","DOI":"10.3390\/jcm15176886","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:12:25Z","timestamp":1788783145000},"page":"6886","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Tranexamic Acid in Abdominoplasty: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0143-7645","authenticated-orcid":false,"given":"Kholoud","family":"Almahzoum","sequence":"first","affiliation":[{"name":"Department of General Surgery, Sheikh Jaber Al-Ahmad Al-Sabah Hospital, Ministry of Health, Kuwait City 13018, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2330-2030","authenticated-orcid":false,"given":"Abdulaziz","family":"Alenezi","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Sheikh Jaber Al-Ahmad Al-Sabah Hospital, Kuwait City 13018, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Refah Fahad","family":"Alajmi","sequence":"additional","affiliation":[{"name":"Kuwait Institute for Medical Specializations, Kuwait City 12050, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar W.","family":"Alrumaih","sequence":"additional","affiliation":[{"name":"School of Medicine, The University of Jordan, Amman 11942, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8404-5856","authenticated-orcid":false,"given":"Bader N.","family":"Almutawaa","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Amiri Hospital Kuwait, Ministry of Health, Kuwait City 15300, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1244-7769","authenticated-orcid":false,"given":"Ebraheem","family":"Albazee","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology-Head and Neck Surgery, Kuwait Institute for Medical Specializations (KIMS), Kuwait City 13018, Kuwait"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Al-Jahra Hospital, Al-Jahra 03200, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Altarrah","sequence":"additional","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery, Sheikh Jaber Al-Ahmad Al-Sabah Hospital, Kuwait City 13018, Kuwait"},{"name":"Kuwait Institute for Medical Specializations, Kuwait City 12050, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S229","DOI":"10.1097\/SAP.0000000000002639","article-title":"Abdominoplasty: My Preferred Techniques","volume":"86","author":"Ramirez","year":"2021","journal-title":"Ann. 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