{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:16:31Z","timestamp":1789042591447,"version":"build-2803163510"},"reference-count":35,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background and Objectives: Femoral arterial calcification (FAC) on routine hip radiographs may provide opportunistic vascular information within orthogeriatric assessment. We evaluated the associations of FAC and the Atherogenic Index of Plasma (AIP) with 1-year mortality after hip-fracture surgery. Materials and Methods: This retrospective single-centre cohort included 229 patients aged 65 years or older. FAC was graded from 0 to 3 on preoperative radiographs using an exploratory semiquantitative classification. AIP was calculated as log10(TG\/HDL-C). Logistic regression and complementary survival analyses were partially adjusted for age, sex, FAC, and AIP. Incremental discrimination was assessed using nested age + sex, age + sex + FAC, and age + sex + FAC + AIP models. Results: Thirty-eight patients (16.6%) died within 1 year. Interobserver agreement for FAC grading was almost perfect (\u03ba = 0.87). Each one-grade increase in FAC was associated with mortality in the partially adjusted logistic (OR = 1.44, 95% CI 1.09\u20131.91) and Cox models (HR = 1.36, 95% CI 1.07\u20131.73). AIP was not significantly associated with mortality. AUCs were 0.726 for age + sex, 0.757 for age + sex + FAC, and 0.761 for age + sex + FAC + AIP; neither incremental increase was significant. Conclusions: Radiographic FAC was associated with 1-year mortality but did not demonstrate significant incremental discrimination beyond age and sex. FAC may serve as an opportunistic marker within multidisciplinary orthogeriatric assessment, not as a stand-alone prognostic tool. AIP findings remain inconclusive because sampling occurred during acute admission without standardised fasting. Prospective multicentre validation with comprehensive geriatric covariates is required.<\/jats:p>","DOI":"10.3390\/jcm15187019","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:38:39Z","timestamp":1789040319000},"page":"7019","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Femoral Arterial Calcification, Atherogenic Index of Plasma, and 1-Year Mortality After Hip Fracture: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7845-1974","authenticated-orcid":false,"given":"Ahmet","family":"Yi\u011fitbay","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Traumatology, \u0130zmir Tepecik Training and Research Hospital, University of Health Sciences, 35170 \u0130zmir, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erim Can","family":"Demircan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, 34147 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3040-5586","authenticated-orcid":false,"given":"Muhammed Fatih","family":"Civan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, 34147 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alev","family":"Kural","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, 34147 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cemal","family":"Kural","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, 34147 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Can","family":"Koluman","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, University of Health Sciences, 34147 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2595-9459","authenticated-orcid":false,"given":"Nezih","family":"Ziro\u011flu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Traumatology, Acibadem University Atakent Hospital, 34303 Istanbul, Turkey"},{"name":"Vocational School of Health Services, Department of Orthopedic Prosthetics and Orthotics, Acibadem Mehmet Ali Aydinlar University, 34638 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00198-023-06907-3","article-title":"Global burden of hip fracture: The Global Burden of Disease Study","volume":"35","author":"Feng","year":"2024","journal-title":"Osteoporos. Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1007\/s40520-023-02378-y","article-title":"Functional autonomy and 12-month mortality in older adults with proximal femoral fractures in an orthogeriatric setting: Risk factors and gender differences","volume":"35","author":"Ceolin","year":"2023","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00198-019-04858-2","article-title":"The orthogeriatric comanagement improves clinical outcomes of hip fracture in older adults","volume":"30","author":"Baroni","year":"2019","journal-title":"Osteoporos. Int."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Salvesen, E.S., Taraldsen, K., L\u00f8nne, G., Lydersen, S., Lamb, S.E., Opdal, K., Saltvedt, I., and Johnsen, L.G. (2025). Characteristics and outcomes for hip fracture patients in an integrated orthogeriatric care model: A descriptive study of four discharge pathways with one-year follow-up. BMC Musculoskelet. Disord., 26.","DOI":"10.1186\/s12891-025-08427-z"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"105321","DOI":"10.1016\/j.jamda.2024.105321","article-title":"Efficacy of Fragility Fracture Integrated Rehabilitation Management in Older Adults With Hip Fractures: A Randomized Controlled Trial With 1-Year Follow-Up","volume":"26","author":"Lim","year":"2025","journal-title":"J. Am. Med. Dir. Assoc."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jhqr.2018.10.010","article-title":"Achieving quadruple aim goals through clinical networks: A systematic review","volume":"34","author":"Leigheb","year":"2019","journal-title":"J. Healthc. Qual. Res."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Brown, B.B., Patel, C., McInnes, E., Mays, N., Young, J., and Haines, M. (2016). The effectiveness of clinical networks in improving quality of care and patient outcomes: A systematic review of quantitative and qualitative studies. BMC Health Serv. Res., 16.","DOI":"10.1186\/s12913-016-1615-z"},{"key":"ref_8","first-page":"E212","article-title":"Peripheral arterial calcification: Prevalence, mechanism, detection, and clinical implications","volume":"83","author":"Zeller","year":"2014","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_9","first-page":"e46437","article-title":"Does Femoral Arterial Calcification Have an Effect on Mortality in Patients Who Underwent Hemiarthroplasty Due to Hip Fracture?","volume":"15","year":"2023","journal-title":"Cureus"},{"key":"ref_10","first-page":"e14878","article-title":"Does Presence of Femoral Arterial Calcification Have an Effect on Postoperative Complication and Mortality in Patients With Hip Fracture?","volume":"13","author":"Bilgin","year":"2021","journal-title":"Cureus"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3388","DOI":"10.1016\/j.injury.2021.07.027","article-title":"Radiological parameter associated with the survival of old patients with hip fracture","volume":"52","author":"Bayram","year":"2021","journal-title":"Injury"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0009-9120(01)00263-6","article-title":"The plasma parameter log (TG\/HDL-C) as an atherogenic index: Correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL)","volume":"34","author":"Frohlich","year":"2001","journal-title":"Clin. Biochem."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jacl.2010.02.005","article-title":"\u201cAtherogenic Index of Plasma\u201d (log10 triglyceride\/high-density lipoprotein-cholesterol) predicts high blood pressure, diabetes, and vascular events","volume":"4","author":"Onat","year":"2010","journal-title":"J. Clin. Lipidol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1177\/00033197211054242","article-title":"The plasma atherogenic index is an independent predictor of arterial stiffness in healthy Koreans","volume":"73","author":"Nam","year":"2022","journal-title":"Angiology"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Zhong, L., Liao, Y., and Zhong, Y. (2025). The relationship between the atherogenic index of plasma and postoperative myocardial injury following non-cardiac surgery under general anaesthesia: A retrospective cohort study. BMC Cardiovasc. Disord., 25.","DOI":"10.1186\/s12872-025-04534-w"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"98","DOI":"10.2399\/ana.19.051","article-title":"Is femoral artery calcification a sign of mortality in elderly hip fractures?","volume":"13","author":"Ekici","year":"2019","journal-title":"Anatomy"},{"key":"ref_17","unstructured":"Burapachaisri, A., Yacovelli, S.J., Stocchi, C., Rako, K., Forsh, D., and Podolnick, J. (2026, September 07). Femoral Vessel Calcification is an Independent Risk Factor for Postoperative Complication following Surgical Treatment of Hip Fractures. Available online: https:\/\/www.researchgate.net\/publication\/385384490."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.ijsu.2018.02.061","article-title":"Preventable risk factors of mortality after hip fracture surgery: Systematic review and meta-analysis","volume":"52","author":"Chang","year":"2018","journal-title":"Int. J. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"380","DOI":"10.7326\/0003-4819-152-6-201003160-00008","article-title":"Meta-analysis: Excess mortality after hip fracture among older women and men","volume":"152","author":"Haentjens","year":"2010","journal-title":"Ann. Intern. Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Graif, N., Elbaz, E., Warschawski, Y., Kazum, E., Shabtai, L., Amzallag, N., and Factor, S. (2025). The Impact of Concomitant Upper Extremity Fractures on Outcomes in Geriatric Patients Following Hip Fracture Surgery. J. Clin. Med., 14.","DOI":"10.3390\/jcm14186380"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Khalil, K., Jamaleddine, Y., Haj Hussein, A., Daccache, E., Mouawad, J., Fricault, G., Khoury, A., and Reina, N. (2025). Early Postoperative Mortality Risk Factors and Five- and Ten-Year Mortality Rates After Hip Arthroplasty for Femoral Neck Fracture. J. Clin. Med., 14.","DOI":"10.3390\/jcm14238263"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Kim, Y.J., Park, J.-I., Kim, H., Koh, W.U., Ro, Y.-J., and Kim, H.-J. (2025). Association of Prognostic Nutritional Index and Mortality in Older Adults Undergoing Hip Fracture Surgery: A Retrospective Observational Study at a Single Large Center. Medicina, 61.","DOI":"10.3390\/medicina61081376"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Garc\u00eda-Tercero, E., Belenguer-Varea, \u00c1., Villalon-Ruibio, D., L\u00f3pez G\u00f3mez, J., Trigo-Suarez, R., Cunha-P\u00e9rez, C., Borda, M.G., and Tarazona-Santabalbina, F.J. (2024). Respiratory Complications Are the Main Predictors of 1-Year Mortality in Patients with Hip Fractures: The Results from the Alzira Retrospective Cohort Study. Geriatrics, 9.","DOI":"10.3390\/geriatrics9020047"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Desai, V., Chan, P.H., Royse, K.E., Navarro, R.A., Diekmann, G.R., Yamaguchi, K.T., Paxton, E.W., and Qiu, C. (2025). Factors Associated with Mortality and Short-Term Patient Outcomes for Hip Fracture Repair in the Elderly Based on Preoperative Anticoagulation Status. Geriatrics, 10.","DOI":"10.3390\/geriatrics10020054"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Krakers, S.M., Woudsma, S., van Dartel, D., Vermeer, M., Vollenbroek-Hutten, M.M.R., Hegeman, J.H., and on behalf of the Up&Go after a Hip Fracture Group (2024). Rehabilitation of Frail Older Adults after Hip Fracture Surgery: Predictors for the Length of Geriatric Rehabilitation Stay at a Skilled Nursing Home. J. Clin. Med., 13.","DOI":"10.3390\/jcm13154547"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"P\u00eeslaru, A.I., S\u00eerbu, I., Albi\u0219teanu, S.-M., \u0218tef\u0103niu, R., Turcu, A.-M., Grigora\u0219, G., Lungu, I.-D., P\u00eenzaru, R.M., Alexa, I.D., and Ilie, A.C. (2025). Geriatric Assessment as an Important Tool for Post-Hip Surgery Prognosis in Seniors. Nurs. Rep., 15.","DOI":"10.3390\/nursrep15070262"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"e8058","DOI":"10.1097\/MD.0000000000008058","article-title":"The atherogenic index of plasma is a strong and independent predictor for coronary artery disease in the Chinese Han population","volume":"96","author":"Cai","year":"2017","journal-title":"Medicine"},{"key":"ref_28","first-page":"240","article-title":"Atherogenic Index of Plasma (AIP): A marker of cardiovascular disease","volume":"29","author":"Niroumand","year":"2015","journal-title":"Med. J. Islam. Repub. Iran"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Lan, J., Yi, C., Liu, R., Guo, J., Tu, S., Wu, H., Lin, J., Mao, H., Ye, H., and Chen, W. (2025). Association Between Atherogenic Index of Plasma and Clinical Outcomes in Peritoneal Dialysis Population. J. Clin. Med., 14.","DOI":"10.20944\/preprints202505.0644.v1"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1093\/eurheartj\/ehu163","article-title":"Medial vascular calcification revisited: Review and perspectives","volume":"35","author":"Lanzer","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_31","first-page":"365","article-title":"Is The Presence of Vascular Calcification In Hip X-Rays A Predictor of Postoperative Mortality in Intertrochanteric Fracture of The Femur?","volume":"24","author":"Karatekin","year":"2022","journal-title":"K\u0131r\u0131kkale \u00dcni T\u0131p Derg. A\u011fustos"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e015410","DOI":"10.1161\/JAHA.119.015410","article-title":"Combining Biomarkers and Imaging for Short-Term Assessment of Cardiovascular Disease Risk in Apparently Healthy Adults","volume":"9","author":"Gore","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"ref_33","first-page":"7065","article-title":"The role of ASA score and Charlson comorbidity index in predicting in-hospital mortality in geriatric hip fracture patients","volume":"27","year":"2023","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Moja, L., Piatti, A., Pecoraro, V., Ricci, C., Virgili, G., Salanti, G., Germagnoli, L., Liberati, A., and Banfi, G. (2012). Timing matters in hip fracture surgery: Patients operated within 48 hours have better outcomes. A meta-analysis and meta-regression of over 190,000 patients. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0046175"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1111\/aas.13581","article-title":"Novel biomarkers for prediction of outcome in hip fracture patients-An exploratory study","volume":"64","author":"Jonsson","year":"2020","journal-title":"Acta Anaesthesiol. Scand."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/18\/7019\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:51:23Z","timestamp":1789041083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/18\/7019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":35,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["jcm15187019"],"URL":"https:\/\/doi.org\/10.3390\/jcm15187019","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]}}}