{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:47:50Z","timestamp":1789469270568,"version":"build-2803163510"},"reference-count":25,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: Most evidence on SARS-CoV-2 infection in pregnancy comes from hospitalised or symptomatic cohorts sampled early in the pandemic. We described maternal and neonatal outcomes in an unselected cohort of PCR-confirmed infections ending in live birth, identified characteristics associated with neonatal intensive care unit (NICU) admission and with prolonged maternal hospitalisation, and benchmarked event rates against national data. Methods: A retrospective cohort of all pregnant women with a positive nasopharyngeal SARS-CoV-2 RT-PCR result at a Turkish tertiary centre between March 2020 and May 2023. Of 151 women identified, 133 had retrievable records; eight pregnancies did not end in a live birth, leaving 125. Prespecified subgroups (NICU admission; maternal stay &gt; 3 days) were compared using Mann\u2013Whitney U and \u03c72\/Fisher exact tests, and cohort proportions with 2024 Turkish national rates by one-sample exact binomial tests. Results: The mean maternal age was 29.9 \u00b1 5.5 years and gestational age at delivery was 38.0 \u00b1 2.0 weeks; 19 women (15.2%) delivered preterm and 76 (60.8%) were diagnosed in the third trimester. Sixteen neonates (12.8%) required NICU care and two mothers (1.6%) intensive care; there were no maternal deaths or stillbirths. NICU admission was associated with preterm birth (56.2% vs. 9.2%, p &lt; 0.001) and lower Apgar scores, and prolonged maternal stay with preterm birth, pregnancy-related comorbidity, and caesarean delivery (all p \u2264 0.001). Neither the trimester of infection nor vaccination status was associated with either outcome. Caesarean (64.0%) and preterm birth (15.2%) rates did not exceed national values (p = 0.58 and p = 0.42). Conclusions: Adverse outcomes clustered with preterm delivery and pre-existing pregnancy complications rather than with the timing of infection. Without a matched control group, and with power limited to large effects, these descriptive findings cannot exclude a clinically important effect of SARS-CoV-2.<\/jats:p>","DOI":"10.3390\/jcm15187069","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:39:24Z","timestamp":1789137564000},"page":"7069","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal and Neonatal Outcomes in Pregnancies with PCR-Confirmed SARS-CoV-2 Infection Ending in Live Birth: A Single-Centre Turkish Cohort Benchmarked Against National Reference Data"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8829-6011","authenticated-orcid":false,"given":"O\u011fuzhan","family":"El\u00e7i","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cerrahpa\u015fa Faculty of Medicine, Istanbul University-Cerrahpa\u015fa, 34098 Istanbul, T\u00fcrkiye"},{"name":"Department of Obstetrics and Gynecology, Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital, 34480 Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8135-3788","authenticated-orcid":false,"given":"Ali","family":"Benian","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Cerrahpa\u015fa Faculty of Medicine, Istanbul University-Cerrahpa\u015fa, 34098 Istanbul, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ajog.2021.08.054","article-title":"An update on COVID-19 and pregnancy","volume":"226","author":"Jamieson","year":"2022","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"E540","DOI":"10.1503\/cmaj.202604","article-title":"The impact of COVID-19 on pregnancy outcomes: A systematic review and meta-analysis","volume":"193","author":"Wei","year":"2021","journal-title":"CMAJ"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1001\/jama.2022.1190","article-title":"Association of SARS-CoV-2 infection with serious maternal morbidity and mortality from obstetric complications","volume":"327","author":"Metz","year":"2022","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0140-6736(22)02467-9","article-title":"Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: A multinational, observational study","volume":"401","author":"Villar","year":"2023","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1038\/s41467-020-17436-6","article-title":"Transplacental transmission of SARS-CoV-2 infection","volume":"11","author":"Vivanti","year":"2020","journal-title":"Nat. Commun."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ajog.2020.07.049","article-title":"Vertical transmission of coronavirus disease 2019: A systematic review and meta-analysis","volume":"224","author":"Kotlyar","year":"2021","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1080\/15513815.2020.1747120","article-title":"Vertical transmission of coronavirus disease 19 (COVID-19) from infected pregnant mothers to neonates: A review","volume":"39","author":"Neamatzadeh","year":"2020","journal-title":"Fetal Pediatr. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1007\/s42399-021-00915-2","article-title":"COVID-19 and pregnancy: Risk, symptoms, diagnosis, and treatment","volume":"3","author":"Hapshy","year":"2021","journal-title":"SN Compr. Clin. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/s41577-022-00703-6","article-title":"SARS-CoV-2 infection and COVID-19 vaccination in pregnancy","volume":"22","author":"Male","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/ijgo.14336","article-title":"COVID-19 vaccine and pregnancy outcomes: A systematic review and meta-analysis","volume":"159","author":"Carbone","year":"2022","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Pratama, N.R., Wafa, I.A., Budi, D.S., Putra, M., Wardhana, M.P., and Wungu, C.D.K. (2022). mRNA Covid-19 vaccines in pregnancy: A systematic review. PLoS ONE, 17.","DOI":"10.1371\/journal.pone.0261350"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Paixao, E.S., Wong, K.L.M., Alves, F.J.O., de Ara\u00fajo Oliveira, V., Cerqueira-Silva, T., J\u00fanior, J.B., Machado, T.M., Junior, E.P.P., Boaventura, V.S., and Penna, G.O. (2022). CoronaVac vaccine is effective in preventing symptomatic and severe COVID-19 in pregnant women in Brazil: A test-negative case-control study. BMC Med., 20.","DOI":"10.1186\/s12916-022-02353-w"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies","volume":"370","author":"Altman","year":"2007","journal-title":"Lancet"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"American College of Obstetricians and Gynecologists (2016). Severe maternal morbidity: Screening and review. Obstetric Care Consensus No. 5. Obstet. Gynecol., 128, e54\u2013e60.","DOI":"10.1097\/AOG.0000000000001642"},{"key":"ref_15","unstructured":"Republic of T\u00fcrkiye Ministry of Health (2026, July 04). Health Statistics Yearbook 2024 News Bulletin, Available online: https:\/\/dosyasb.saglik.gov.tr\/Eklenti\/51943\/0\/haber-bulteni-2024-enpdf.pdf."},{"key":"ref_16","unstructured":"Turkish Statistical Institute (2026, July 04). Birth Statistics, 2024, Available online: https:\/\/veriportali.tuik.gov.tr\/en\/press\/54196."},{"key":"ref_17","unstructured":"Republic of T\u00fcrkiye Ministry of Health, General Directorate of Public Health (2026, July 04). Premat\u00fcrite [Prematurity]; Ministry of Health: Ankara, T\u00fcrkiye, (In Turkish)."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1186\/s13054-023-04584-6","article-title":"Impact of Covid-19 on risk of severe maternal morbidity","volume":"27","author":"Auger","year":"2023","journal-title":"Crit. Care"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.whi.2022.08.003","article-title":"Impact of the COVID-19 pandemic on obstetric interventions at a public hospital","volume":"33","author":"Johnson","year":"2023","journal-title":"Women\u2019s Health Issues"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/uog.24931","article-title":"Are in-hospital COVID-19-related mortality and morbidity in pregnancy associated with gestational age?","volume":"60","author":"Leung","year":"2022","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Geng, J., Yu, X., Bao, H., Feng, Z., Yuan, X., Zhang, J., Chen, X., Chen, Y., Li, C., and Yu, H. (2021). Chronic diseases as a predictor for severity and mortality of COVID-19: A systematic review with cumulative meta-analysis. Front. Med., 8.","DOI":"10.3389\/fmed.2021.588013"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e22794","DOI":"10.2196\/22794","article-title":"The association between chronic disease and serious COVID-19 outcomes and its influence on risk perception: Survey study and database analysis","volume":"7","author":"Laires","year":"2021","journal-title":"JMIR Public Health Surveill."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.thromres.2020.04.013","article-title":"Incidence of thrombotic complications in critically ill ICU patients with COVID-19","volume":"191","author":"Klok","year":"2020","journal-title":"Thromb. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"102695","DOI":"10.1016\/j.cpcardiol.2024.102695","article-title":"Maternal-fetal dyad beyond the phenomenology of pregnancy: From primordial cardiovascular prevention on out, do not miss this boat!","volume":"49","author":"Bucciarelli","year":"2024","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41579-022-00846-2","article-title":"Long COVID: Major findings, mechanisms and recommendations","volume":"21","author":"Davis","year":"2023","journal-title":"Nat. Rev. Microbiol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/18\/7069\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:58:00Z","timestamp":1789466280000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/18\/7069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,11]]},"references-count":25,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["jcm15187069"],"URL":"https:\/\/doi.org\/10.3390\/jcm15187069","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,11]]}}}