{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:08:42Z","timestamp":1789391322676,"version":"build-2803163510"},"reference-count":48,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Objectives: To describe short-term anatomical and visual outcomes after platelet-rich plasma (PRP)-assisted surgery for full-thickness macular holes (FTMHs) in a selected real-world cohort, predominantly consisting of previously operated and large holes. Methods: This retrospective, register-based cohort study included 61 eyes of 61 patients who underwent FTMH surgery with adjunctive autologous PRP. Anatomical closure, short-term BCVA change, and exploratory OCT associations were evaluated overall and by surgical subgroup. Results: Seven eyes underwent PRP-assisted primary surgery and 54 underwent repeat surgery. Complete closure occurred in 46\/61 eyes (75.4%; 95% CI, 63.3\u201384.5%). Median BCVA improved from 0.74 to 0.53 logMAR (p &lt; 0.001); results remained directionally consistent in a 21\u201342-day sensitivity window (n = 33; p = 0.016). Nine eyes underwent combined phaco-vitrectomy. Preoperative MLD differed across anatomical outcomes (p = 0.005), where the border-cyst association with postoperative BCVA was not significant after adjustment. Conclusions: PRP-assisted surgery was followed by substantial short-term anatomical closure and visual improvement, but the uncontrolled design, heterogeneous management, and incomplete characterization of prior surgery and PRP preclude attribution of efficacy or safety to PRP.<\/jats:p>","DOI":"10.3390\/jcm15187129","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:09:51Z","timestamp":1789387791000},"page":"7129","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anatomical and Functional Outcomes of Platelet-Rich Plasma-Assisted Surgery for Full-Thickness Macular Holes: A Retrospective Real-World Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6549-3171","authenticated-orcid":false,"given":"Hanna","family":"Haave","sequence":"first","affiliation":[{"name":"Center for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Oslo University Hospital, 0450 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Be\u00e1ta \u00c9va","family":"Petrovski","sequence":"additional","affiliation":[{"name":"Center for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Oslo University Hospital, 0450 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2856-9297","authenticated-orcid":false,"given":"Ivan","family":"Borjan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University Hospital of Split, 21000 Split, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9865-4111","authenticated-orcid":false,"given":"Xhevat","family":"Lumi","sequence":"additional","affiliation":[{"name":"Center for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Oslo University Hospital, 0450 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2905-9252","authenticated-orcid":false,"given":"Goran","family":"Petrovski","sequence":"additional","affiliation":[{"name":"Center for Eye Research and Innovative Diagnostics, Department of Ophthalmology, Oslo University Hospital, 0450 Oslo, Norway"},{"name":"Department of Ophthalmology, Institute for Clinical Medicine, Faculty of Medicine, University of Oslo, 0450 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0039-6257(97)00132-X","article-title":"macular hole","volume":"42","author":"Ho","year":"1998","journal-title":"Surv. 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