{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:30:26Z","timestamp":1789468226584,"version":"build-2803163510"},"reference-count":41,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>The increase in the number of people living after an oncological diagnosis requires the use of instruments capable of assessing both general dimensions and specific aspects of quality of life. The study aimed to evaluate the psychometric properties of the Romanian version of the Quality of Life in Adult Cancer Survivors (QLACS) questionnaire, analyze the relationships between its scores, age, and residence environment, and identify distinct quality of life profiles. Methods: A cross-sectional study was conducted in 224 adult women with a confirmed diagnosis of breast cancer. The internal consistency of the 12 QLACS domains was assessed by Cronbach\u2019s alpha coefficient. The structure of the instrument was explored by principal component analysis with Oblimin rotation. Differences according to residence were analyzed by the Mann\u2013Whitney test, and the relationships with age by the Spearman coefficient. Multivariable regression models including age and residential environment were fitted for all 12 QLACS domains. Quality of life profiles were identified by hierarchical classification and k-means analysis. Results: Cronbach\u2019s alpha coefficients ranged from 0.832 to 0.925, indicating good internal consistency across the 12 QLACS domains. Principal component analysis retained 11 components, explaining 73.738% of the total variance, providing preliminary exploratory support for the multidimensional structure of the instrument. Most domains were clearly delineated, whereas Cognitive problems partially overlapped with Recurrence distress. Urban residence was associated with higher Cognitive problems scores (r = 0.17), whereas rural residence was associated with higher Family distress scores (r = 0.29). Age was negatively correlated with Negative feelings (rho =\u22120.200, p = 0.003). A weak exploratory association was also observed with Recurrence distress (rho = 0.135, p = 0.043), although the corresponding multivariable model was not statistically significant. Cluster analysis identified three exploratory quality-of-life profiles, and residential environment was associated with cluster membership, although the association was small (Cramer\u2019s V = 0.188). Conclusions: The Romanian QLACS showed good internal consistency and preliminary exploratory structural evidence in women with breast cancer. Further studies are needed to confirm its psychometric properties.<\/jats:p>","DOI":"10.3390\/jcm15187151","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:16:48Z","timestamp":1789460208000},"page":"7151","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychometric Evaluation of the Romanian Quality of Life in Adult Cancer Survivors (QLACS) in Women with Breast Cancer: A Cross-Sectional Study"],"prefix":"10.3390","volume":"15","author":[{"given":"Paula Alexandra","family":"Blanaru","sequence":"first","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania"},{"name":"One\u0219ti Municipal Hospital, 601048 Onesti, Romania"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2859-2066","authenticated-orcid":false,"given":"Elena","family":"Porumb-Andrese","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania"},{"name":"Clinical Railways Hospital, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"given":"Cristian","family":"M\u00e2rtu","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"software","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1811-7923","authenticated-orcid":false,"given":"Ramona Gabriela","family":"Ursu","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"software","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9167-6302","authenticated-orcid":false,"given":"Monica Mihaela","family":"Scutariu","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"}]},{"given":"Gabriela Rusu","family":"Zota","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"validation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0891-4857","authenticated-orcid":false,"given":"Vlad","family":"Porumb","sequence":"additional","affiliation":[{"name":"Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania"},{"name":"Dr. Iacob Czihac Emergency Military Clinical Hospital, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"supervision","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","first-page":"308","article-title":"Cancer treatment and survivorship statistics, 2025","volume":"75","author":"Wagle","year":"2025","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1477-7525-4-92","article-title":"Evaluation of the Quality of Life in Adult Cancer Survivors (QLACS) scale for long-term cancer survivors in a sample of breast cancer survivors","volume":"4","author":"Avis","year":"2006","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s11136-004-2147-2","article-title":"Assessing Quality of Life in Adult Cancer Survivors (QLACS)","volume":"14","author":"Avis","year":"2005","journal-title":"Qual. Life Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.jpsychores.2014.07.007","article-title":"Traditional and Rasch psychometric analyses of the Quality of Life in Adult Cancer Survivors (QLACS) questionnaire in shorter-term cancer survivors 15 months post-diagnosis","volume":"77","author":"Ashley","year":"2014","journal-title":"J. Psychosom. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s11136-014-0749-x","article-title":"Evaluation of the Quality of Life in Adult Cancer Survivors (QLACS) scale for early post-treatment breast cancer survivors","volume":"24","author":"Sohl","year":"2015","journal-title":"Qual. Life Res."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"The WHOQOL Group (1995). The World Health Organization Quality of Life Assessment (WHOQOL): Position Paper from the World Health Organization. Soc. Sci. Med., 41, 1403\u20131409.","DOI":"10.1016\/0277-9536(95)00112-K"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Fan, R., Wang, L., Bu, X., Wang, W., and Zhu, J. (2023). Unmet Supportive Care Needs of Breast Cancer Survivors: A Systematic Scoping Review. BMC Cancer, 23.","DOI":"10.1186\/s12885-023-11087-8"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Demos-Davies, K., Lawrence, J., and Seelig, D. (2024). Cancer-related cognitive impairment: A downside of cancer treatment. Front. Oncol., 14.","DOI":"10.3389\/fonc.2024.1387251"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.21037\/apm-24-70","article-title":"Cancer-related cognitive impairment: Updates to treatment, the need for more evidence, and impact on quality of life\u2014A narrative review","volume":"13","author":"Yang","year":"2024","journal-title":"Ann. Palliat. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e71996","DOI":"10.2196\/71996","article-title":"Experiences of cancer-related cognitive impairment across cancer types: Qualitative systematic review","volume":"11","author":"Ibrar","year":"2025","journal-title":"JMIR Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"P\u00e9rez, C., Ochoa, D., S\u00e1nchez, N., Ballesteros, A.I., Santidri\u00e1n, S., L\u00f3pez, I., Mond\u00e9jar, R., Carnaval, T., Villoria, J., and Colomer, R. (2024). Pain in long-term cancer survivors: Prevalence and impact in a cohort composed mostly of breast cancer survivors. Cancers, 16.","DOI":"10.3390\/cancers16081581"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"102234","DOI":"10.1016\/j.esmoop.2024.102234","article-title":"Sexual quality of life of adolescents and young adult breast cancer survivors","volume":"9","author":"Peeters","year":"2024","journal-title":"ESMO Open"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"K\u00e1llay, \u00c9., M\u00fcller-Fabian, A., and D\u00e9gi, C.L. (2024). Fear of cancer progression and the quality of sexual life of female cancer patients in Romania. Front. Public Health, 12.","DOI":"10.3389\/fpubh.2024.1417681"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Schmalz, C., Oberguggenberger, A.S., Nagele, E., Bliem, B., Lanceley, A., Nordin, A., Kuljanic, K., Jensen, P.T., Bjelic-Radisic, V., and Fabian, A. (2024). Sexual health\u2014A topic for cancer patients receiving oncological treatment with palliative intent. BMC Palliat. Care, 23.","DOI":"10.1186\/s12904-024-01513-4"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13643-018-0795-5","article-title":"A protocol for an updated and expanded systematic mixed studies review of fear of cancer recurrence in families and caregivers of adults diagnosed with cancer","volume":"7","author":"Leske","year":"2018","journal-title":"Syst. Rev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s11764-013-0272-z","article-title":"Fear of cancer recurrence in adult cancer survivors: A systematic review of quantitative studies","volume":"7","author":"Simard","year":"2013","journal-title":"J. Cancer Surviv."},{"key":"ref_18","first-page":"44","article-title":"Illness perceptions, fear of cancer recurrence, and mental health in teenage and young adult cancer survivors","volume":"41","author":"Horwood","year":"2024","journal-title":"J. Pediatr. Hematol. Oncol. Nurs."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e2436144","DOI":"10.1001\/jamanetworkopen.2024.36144","article-title":"Fear of cancer recurrence in adult survivors of childhood cancer","volume":"7","author":"Pizzo","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e208","DOI":"10.1017\/S1478951525101016","article-title":"Fear of cancer recurrence: An exploratory study on its impact on quality of life and emotional distress in patients undergoing systemic cancer therapy","volume":"23","author":"Andreis","year":"2025","journal-title":"Palliat. Support. Care"},{"key":"ref_21","first-page":"4219","article-title":"Urban\u2013rural differences in financial toxicity and its effect on cancer survivors\u2019 health-related quality of life and emotional status: A latent class analysis","volume":"30","author":"Xu","year":"2022","journal-title":"Support. Care Cancer"},{"key":"ref_22","first-page":"424","article-title":"Health-related quality of life in rural cancer survivors compared with their urban counterparts: A systematic review","volume":"32","author":"Latham","year":"2024","journal-title":"Support. Care Cancer"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/jrh.12774","article-title":"Rural\u2013urban differences in distress, quality of life, and social support among Canadian young adult cancer survivors: A Young Adults with Cancer in Their Prime (YACPRIME) study","volume":"40","author":"Tulk","year":"2024","journal-title":"J. Rural Health"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s12955-015-0378-2","article-title":"Cross-cultural adaptation, reliability and validity of the Spanish version of the Quality of Life in Adult Cancer Survivors (QLACS) questionnaire: Application in a sample of short-term survivors","volume":"13","author":"Escobar","year":"2015","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_25","unstructured":"OECD, and European Commission (2023). EU Country Cancer Profile: Romania 2025, OECD Publishing. Available online: https:\/\/www.oecd.org\/en\/publications\/2025\/02\/eu-country-cancer-profile-romania-2025_ef833241.html."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Carew, J.W., Radulescu, S.C., Zhang, L., Ungurean, C., Calomfirescu, C., Furtunescu, F., and Soliman, A.S. (2025). Breast cancer mortality in Romania: Trends, regional and rural\u2013urban inequalities, and policy implications. BMC Cancer, 25.","DOI":"10.1186\/s12885-025-14090-3"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.3390\/curroncol30070504","article-title":"Quality of Life in Cancer Patients: The Modern Psycho-Oncologic Approach for Romania\u2014A Review","volume":"30","author":"Licu","year":"2023","journal-title":"Curr. Oncol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Ionescu, A.-I., Anghel, A.-V., Antone-Iordache, I.-L., Atasiei, D.-I., Anghel, C.-A., Barnonschi, A.-A., Bobolocu, A.-M., Verga, C., \u0218andru, F., and Li\u0219cu, H.-D. (2024). Assessing the Impact of Organ Failure and Metastases on Quality of Life in Breast Cancer Patients: A Prospective Study Based on Utilizing EORTC QLQ-C30 and EORTC QLQ-BR45 Questionnaires in Romania. J. Pers. Med., 14.","DOI":"10.3390\/jpm14020214"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Arthur, E.K., Menon, U., Reese, J.B., Browning, K., Overcash, J., Rose, K., and Wills, C.E. (2022). Profiles of women\u2019s adjustment after cancer based on sexual and psychosocial wellbeing: Results of a cluster analysis. BMC Cancer, 22.","DOI":"10.1186\/s12885-022-10093-6"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Park, K.-H., and Song, M.K. (2022). Distress among Korean cancer survivors: A latent profile analysis. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19031613"},{"key":"ref_31","first-page":"308","article-title":"Comparing symptom clusters in cancer survivors by cancer diagnosis: A latent class profile analysis","volume":"32","author":"Lee","year":"2024","journal-title":"Support. Care Cancer"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Xiao, H., Ghazinour, G., Tabaczynski, A., Chong, S.Y., Koperwas, I., and Trinh, L. (2025). Identifying latent profiles of quality of life and lifestyle behaviors in cancer survivors: The interplay of sedentary behavior, physical activity, and sleep. J. Cancer Surviv., 1\u20132.","DOI":"10.1007\/s11764-025-01810-8"},{"key":"ref_33","first-page":"821","article-title":"Heterogeneity of pain-fatigue-sleep disturbance symptom clusters in lung cancer patients after chemotherapy: A latent profile analysis","volume":"32","author":"Zhou","year":"2024","journal-title":"Support. Care Cancer"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s11764-021-01068-w","article-title":"Conceptualizing problems with symptoms, function, health behavior, health-seeking skills, and financial strain in breast cancer survivors using hierarchical clustering","volume":"16","author":"Liu","year":"2022","journal-title":"J. Cancer Surviv."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1007\/s11136-024-03761-6","article-title":"COSMIN guideline for systematic reviews of patient-reported outcome measures version 2.0","volume":"33","author":"Mokkink","year":"2024","journal-title":"Qual. Life Res."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e12223","DOI":"10.1016\/j.heliyon.2022.e12223","article-title":"Sample size in quantitative instrument validation studies: A systematic review of articles published in Scopus, 2021","volume":"8","author":"White","year":"2022","journal-title":"Heliyon"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1037\/0033-2909.99.3.432","article-title":"Comparison of five rules for determining the number of components to retain","volume":"99","author":"Zwick","year":"1986","journal-title":"Psychol. Bull."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Wang, B., Hu, X., Ding, W., Guo, H., and Ren, X. (2025). Supportive Care Needs and Quality of Life among Cancer Patients in China: A Cross-sectional Study. PLoS ONE, 20.","DOI":"10.1371\/journal.pone.0331149"},{"key":"ref_39","first-page":"5997","article-title":"Urban or rural residence and symptom clustering: A population-based cluster analysis","volume":"22","author":"Murchie","year":"2024","journal-title":"Ann. Fam. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e7139","DOI":"10.1002\/cam4.7139","article-title":"A longitudinal study of symptom cluster latent profiles in ovarian cancer patients undergoing chemotherapy","volume":"13","author":"Feng","year":"2024","journal-title":"Cancer Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4103\/ijc.ijc_389_21","article-title":"Predictors of quality of life of cancer patients: A psycho-oncological study conducted at Tripura, North-East India","volume":"61","author":"Bhattacharjee","year":"2024","journal-title":"Indian J. Cancer"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/18\/7151\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:57:11Z","timestamp":1789462631000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/18\/7151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":41,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["jcm15187151"],"URL":"https:\/\/doi.org\/10.3390\/jcm15187151","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]}}}