{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:06:45Z","timestamp":1790078805055,"version":"4.0.1"},"reference-count":21,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: Vaginal natural orifice transluminal endoscopic surgery lateral suspension (vNOTES-LS) may reduce the perioperative burden of conventional laparoscopic lateral suspension (LLS), but comparative evidence remains limited. We compared perioperative, anatomical, safety, and patient-reported outcomes. Methods: This single-center retrospective cohort included 97 women with stage III\u2013IV pelvic organ prolapse who underwent vNOTES-LS (n = 33) or LLS (n = 64) and completed 12-month follow-up. The primary outcome was anatomical success at 12 months. Results: Operating time was shorter with vNOTES-LS (78.0 \u00b1 16.6 vs. 110.0 \u00b1 14.2 min; p &lt; 0.001), as were estimated blood loss, hospitalization, and 24-h pain scores. After adjustment, vNOTES-LS was associated with a 31.7-min shorter operating time (95% CI, \u221238.7 to \u221224.6; p &lt; 0.001). Anatomical success was 87.9% versus 89.1% (p = 1.000; RR, 0.99; 95% CI, 0.85\u20131.15), with an absolute risk difference of \u22121.2 percentage points (95% CI, \u221214.7 to 12.3). Cumulative mesh exposure within 12 months was 9.1% and 9.4%, respectively. No statistically significant between-group differences were detected in recurrence, measured safety outcomes, or longitudinal changes in the Pelvic Floor Distress Inventory-20 (PFDI-20), Pelvic Floor Impact Questionnaire-7 (PFIQ-7), and 12-item Pelvic Organ Prolapse\/Urinary Incontinence Sexual Questionnaire (PISQ-12). Conclusions: vNOTES-LS was associated with shorter operating time and favorable early perioperative outcomes. Observed 12-month anatomical success rates were not statistically significantly different; however, equivalence or non-inferiority cannot be concluded.<\/jats:p>","DOI":"10.3390\/jcm15187250","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:09:35Z","timestamp":1790075375000},"page":"7250","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["vNOTES Versus Laparoscopic Lateral Suspension for Advanced Pelvic Organ Prolapse: A Single-Center, Single-Surgeon Retrospective Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3593-6628","authenticated-orcid":false,"given":"Serhat","family":"Sar\u0131kaya","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Health Sciences, \u0130zmir Tepecik Training and Research Hospital, 35180 Izmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"Yunus Emre","family":"Purut","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Health Sciences, \u0130zmir Tepecik Training and Research Hospital, 35180 Izmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6559-7002","authenticated-orcid":false,"given":"An\u0131l Do\u011fukan","family":"Tutal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Health Sciences, \u0130zmir Tepecik Training and Research Hospital, 35180 Izmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6013-6602","authenticated-orcid":false,"given":"Ceren","family":"Sa\u011flam Purut","sequence":"additional","affiliation":[{"name":"Department of Perinatology, \u0130zmir Atat\u00fcrk Training and Research Hospital, 35150 Izmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6394-3638","authenticated-orcid":false,"given":"G\u00f6kt\u00fcrk Han","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Health Sciences, \u0130zmir Tepecik Training and Research Hospital, 35180 Izmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5608-060X","authenticated-orcid":false,"given":"Sercan","family":"Kantarc\u0131","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Health Sciences, \u0130zmir Tepecik Training and Research Hospital, 35180 Izmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Adnan","family":"Budak","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Health Sciences, \u0130zmir Tepecik Training and Research Hospital, 35180 Izmir, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0002-9378(96)70243-0","article-title":"The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction","volume":"175","author":"Bump","year":"1996","journal-title":"Am. 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