{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:09:49Z","timestamp":1790078989778,"version":"4.0.1"},"reference-count":18,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Introduction: Severe local envenomation following extremity snakebite may mimic acute compartment syndrome and complicate surgical assessment. We aimed to describe the clinical, laboratory, and treatment-timing characteristics of patients managed with and without fasciotomy. Methods: This single-center retrospective study included patients with extremity snakebite treated between 2023 and 2025. A six-item clinical profile score was constructed retrospectively to summarize documented local findings: pain at rest, pain with passive motion, delayed capillary refill, marked swelling or tenseness, paresthesia, and motor deficit (1 point for documented presence, 0 for documented absence; range, 0\u20136). Clinical, laboratory, and treatment-timing characteristics were compared between patients managed with and without fasciotomy; analyses were exploratory and interpreted descriptively. Results: The overall cohort included 50 patients, six of whom underwent fasciotomy. Antivenom administration was documented in 25 patients, absent in 14, and unknown in 11. The complete-case subset comprised 35 patients, including 21 antivenom-treated patients. Within this subset, patients undergoing fasciotomy had higher clinical profile scores (median, 6 vs. 1) and longer bite-to-presentation intervals (median, 4.5 vs. 2 h; both p &lt; 0.001). No significant between-group difference was detected in emergency department arrival-to-antivenom intervals (p = 0.129). Platelet counts were lower and activated partial thromboplastin time was longer in the fasciotomy group. Median bite-to-fasciotomy and antivenom-to-fasciotomy intervals were 8 and 2 h, respectively. Conclusions: Patients selected for fasciotomy had more pronounced documented local findings and later presentation. These exploratory associations do not establish surgical necessity or pressure-confirmed acute compartment syndrome; the retrospectively constructed clinical profile score remains descriptive, without established diagnostic validity.<\/jats:p>","DOI":"10.3390\/jcm15187260","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:09:35Z","timestamp":1790075375000},"page":"7260","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extremity Snakebite in Routine Clinical Practice: Clinical, Laboratory, and Treatment-Timing Characteristics of Patients Managed with and Without Fasciotomy"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3822-5590","authenticated-orcid":false,"given":"G\u00fcne\u015f","family":"Sar\u0131kaya","sequence":"first","affiliation":[{"name":"Orthopedics and Traumatology Clinic, Bal\u0131kesir Atat\u00fcrk City Hospital, Bal\u0131kesir 10100, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0187-8525","authenticated-orcid":false,"given":"M\u00fccahit","family":"\u00c7elik","sequence":"additional","affiliation":[{"name":"Orthopedics and Traumatology Clinic, Bal\u0131kesir Atat\u00fcrk City Hospital, Bal\u0131kesir 10100, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5585-9015","authenticated-orcid":false,"given":"Fatih","family":"I\u015f\u0131k","sequence":"additional","affiliation":[{"name":"Orthopedics and Traumatology Clinic, Bal\u0131kesir Atat\u00fcrk City Hospital, Bal\u0131kesir 10100, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7430-1768","authenticated-orcid":false,"given":"\u00d6zg\u00fcn","family":"Karaku\u015f","sequence":"additional","affiliation":[{"name":"Orthopedics and Traumatology Clinic, Bal\u0131kesir Atat\u00fcrk City Hospital, University of Health Sciences T\u00fcrkiye, Bal\u0131kesir 10100, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2026, June 30). 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