{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:11:04Z","timestamp":1790079064577,"version":"4.0.1"},"reference-count":88,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS\/HIPEC) is a complex, high-risk procedure associated with profound haemodynamic and metabolic perturbations. Perioperative fluid management and the risk of acute kidney injury (AKI) represent two of the most clinically significant and mechanistically interrelated anaesthetic challenges in this setting. This scoping review aimed to synthesise the current evidence on perioperative fluid therapy strategies and renal protection in CRS\/HIPEC, examining the pathophysiological rationale, comparative outcomes of different fluid therapy strategies, haemodynamic monitoring modalities, AKI incidence and risk factors, and pharmacological nephroprotective strategies. Methods: The review followed PRISMA guidelines and was registered in the Open Science Framework (osf.io\/864pr). Studies specifically addressing fluid management, haemodynamic monitoring, AKI, and nephroprotection in adult patients undergoing CRS\/HIPEC were included. Results: Thirty-one studies met inclusion criteria across two thematic domains: 13 addressing fluid therapy (two RCTs, one systematic review, and 10 observational studies) and 18 addressing AKI and renal protection (two RCTs, one systematic review, and 15 observational studies). Liberal intraoperative fluid administration is independently associated with increased morbidity and prolonged hospital stay. Restrictive and goal-directed strategies appear safe and are associated with improved outcomes. AKI incidence ranges from 7.9% to 45.5% depending on chemotherapy regimen, with platin- and taxane-based HIPEC conferring the highest risk. Sodium thiosulfate, amifostine, and cilastatin demonstrate nephroprotective effects in retrospective cohorts; dexmedetomidine shows subclinical renal biomarker benefits in the only RCT identified. Conclusions: The available evidence supports restrictive and goal-directed fluid strategies guided by dynamic haemodynamic monitoring, alongside individualised, cisplatin-dose-adapted nephroprotective protocols. Both fluid overload and renal hypoperfusion represent modifiable risk factors for AKI in CRS\/HIPEC. Prospective randomised trials integrating fluid management and renal outcome endpoints are required.<\/jats:p>","DOI":"10.3390\/jcm15187307","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:09:35Z","timestamp":1790075375000},"page":"7307","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perioperative Fluid Management and Renal Protection in Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy (CRS\/HIPEC): A Scoping Review"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0245-9670","authenticated-orcid":false,"given":"Gilda","family":"Pasta","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Pain Therapy and Intensive Care, INT IRCCS Fondazione G. Pascale, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0533-8284","authenticated-orcid":false,"given":"Camilla","family":"L\u2019Acqua","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Intensive Care, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Filetici","sequence":"additional","affiliation":[{"name":"Department of Science of Emergency, Anesthesiology and Intensive Care, IRCCS Policlinico A. Gemelli Foundation, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2112-2340","authenticated-orcid":false,"given":"Giulia","family":"Bernardi","sequence":"additional","affiliation":[{"name":"Department of Science of Emergency, Anesthesiology and Intensive Care, IRCCS Policlinico A. Gemelli Foundation, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Cuomo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Pain Therapy and Intensive Care, INT IRCCS Fondazione G. Pascale, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9182-6964","authenticated-orcid":false,"given":"Edoardo","family":"De Robertis","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Perugia, 06122 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5489-2898","authenticated-orcid":false,"given":"Tiziana","family":"Bove","sequence":"additional","affiliation":[{"name":"Department of Science of Emergency, Anesthesiology and Intensive Care, IRCCS Policlinico A. Gemelli Foundation, 00168 Rome, Italy"},{"name":"Department of Basic Biotechnological Sciences, Intensive Care Peri-Operative Clinics, Universit\u00e0 Cattolica del Sacro Cuore, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7361-4052","authenticated-orcid":false,"given":"Rachele","family":"Simonte","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Perugia, 06122 Perugia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6406-2591","authenticated-orcid":false,"given":"Luciano","family":"Frassanito","sequence":"additional","affiliation":[{"name":"Department of Science of Emergency, Anesthesiology and Intensive Care, IRCCS Policlinico A. Gemelli Foundation, 00168 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1200\/JCO.2011.39.7166","article-title":"Early- and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy","volume":"30","author":"Chua","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S1470-2045(20)30599-4","article-title":"Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy versus cytoreductive surgery alone for colorectal peritoneal metastases (PRODIGE7): A multicentre, randomised, open-label, phase 3 trial","volume":"22","author":"Elias","year":"2021","journal-title":"Lancet Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.ejso.2016.09.008","article-title":"Best practice for perioperative management of patients with cytoreductive surgery and HIPEC","volume":"43","author":"Schneider","year":"2017","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Jain, A.J., and Badgwell, B.D. (2023). Current Evidence for the Use of HIPEC and Cytoreductive Surgery in Gastric Cancer Metastatic to the Peritoneum. J. Clin. Med., 12.","DOI":"10.3390\/jcm12206527"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ejso.2020.02.011","article-title":"Peritoneal mesothelioma: PSOGI\/EURACAN clinical practice guidelines for diagnosis, treatment and follow-up","volume":"47","author":"Kusamura","year":"2021","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejso.2020.02.012","article-title":"Appendiceal tumours and pseudomyxoma peritonei: Literature review with PSOGI\/EURACAN clinical practice guidelines for diagnosis and treatment","volume":"47","author":"Govaerts","year":"2021","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Biacchi, D., Angrisani, M., Picone, V., Scuto, D., Gallotti, M.G., Accarpio, F., Iafrate, F., Masci, G., Iannone, I., and Spagnoli, A. (2025). Bidirectional Neoadjuvant Chemotherapy for Patients with Gastric Cancer and Synchronous Peritoneal Metastases (GCPMs): Results of a Western Phase II Study. J. Clin. Med., 14.","DOI":"10.3390\/jcm14186518"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"516","DOI":"10.21037\/jgo-20-494","article-title":"Oxaliplatin-based hyperthermic intraperitoneal chemotherapy with single drug versus multiple drug treatment for colorectal cancer with peritoneal metastases: An observational cohort study","volume":"12","author":"Ghanipour","year":"2021","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1245\/s10434-024-15042-0","article-title":"Expanding the Use of HIPEC in Ovarian Cancer at Time of Interval Debulking Surgery to FIGO Stage IV and After 6 Cycles of Neoadjuvant Chemotherapy: A Prospective Analysis on Perioperative and Oncologic Outcomes","volume":"31","author":"Ghirardi","year":"2024","journal-title":"Ann. Surg. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0959-8049(97)00370-5","article-title":"Intraperitoneal cisplatin with regional hyperthermia in advanced ovarian cancer: Pharmacokinetics and cisplatin-DNA adduct formation in patients and ovarian cancer cell lines","volume":"34","author":"Zoetmulder","year":"1998","journal-title":"Eur. J. Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s13193-016-0508-2","article-title":"Anaesthetic Considerations in the Perioperative Management of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy","volume":"7","author":"Sheshadri","year":"2016","journal-title":"Indian J. Surg. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3950","DOI":"10.1245\/s10434-018-6823-9","article-title":"Postoperative Complications Independently Predict Cancer-Related Survival in Peritoneal Malignancies","volume":"25","author":"Choudry","year":"2018","journal-title":"Ann. Surg. Oncol."},{"key":"ref_13","first-page":"99","article-title":"Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A review of factors contributing to morbidity and mortality","volume":"7","author":"Newton","year":"2016","journal-title":"J. Gastrointest. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1097\/SLA.0000000000005101","article-title":"Half of Postoperative Deaths After Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Could be Preventable: A French Root Cause Analysis on 5562 Patients","volume":"274","author":"Glehen","year":"2021","journal-title":"Ann. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"9098","DOI":"10.1245\/s10434-021-10193-w","article-title":"HIPEC Methodology and Regimens: The Need for an Expert Consensus","volume":"28","author":"Bhatt","year":"2021","journal-title":"Ann. Surg. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1213\/00000539-199405000-00018","article-title":"Cardiovascular changes during continuous hyperthermic peritoneal perfusion","volume":"78","author":"Shime","year":"1994","journal-title":"Anesth. Analg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1749-8090-9-125","article-title":"Anaesthetic management of cytoreductive surgery followed by hyperthermic intrathoracic chemotherapy perfusion","volume":"9","author":"Kerscher","year":"2014","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/j.1365-2044.1996.tb14998.x","article-title":"Anaesthesia for intra-peritoneal perfusion of hyperthermic chemotherapy Haemodynamic changes, oxygen consumption and delivery","volume":"51","author":"Kanakoudis","year":"1996","journal-title":"Anaesthesia"},{"key":"ref_19","first-page":"310","article-title":"Time course of cytokines, hemodynamic and metabolic parameters during hyperthermic intraperitoneal chemotherapy","volume":"82","author":"Coccolini","year":"2016","journal-title":"Minerva Anestesiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1245\/s10434-007-9429-1","article-title":"Impact of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy on systemic toxicity","volume":"14","author":"Kusamura","year":"2007","journal-title":"Ann. Surg. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/jso.20013","article-title":"Toxicity of cytoreductive surgery and hyperthermic intra-peritoneal chemotherapy","volume":"85","author":"Verwaal","year":"2004","journal-title":"J. Surg. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jss.2009.04.034","article-title":"Sepsis and major abdominal surgery lead to flaking of the endothelial glycocalix","volume":"165","author":"Steppan","year":"2011","journal-title":"J. Surg. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/1354750X.2020.1787518","article-title":"Glycocalyx damage biomarkers in healthy controls, abdominal surgery, and sepsis: A scoping review","volume":"25","author":"Yanase","year":"2020","journal-title":"Biomarkers"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.ejso.2020.02.006","article-title":"Hemodynamic and respiratory implications of high intra-abdominal pressure during HIPEC","volume":"46","author":"Reis","year":"2020","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_25","first-page":"1015","article-title":"Goal-directed therapy in cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: A prospective observational study","volume":"21","year":"2019","journal-title":"Clin. Transl. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/ALN.0b013e3181863117","article-title":"A rational approach to perioperative fluid management","volume":"109","author":"Chappell","year":"2008","journal-title":"Anesthesiology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.bja.2017.10.011","article-title":"Current concepts of fluid management in enhanced recovery pathways","volume":"120","author":"Makaryus","year":"2018","journal-title":"Br. J. Anaesth."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.bja.2025.05.033","article-title":"Perioperative Quality Initiative consensus statement on goal-directed haemodynamic therapy","volume":"135","author":"Edwards","year":"2025","journal-title":"Br. J. Anaesth."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00000542-200507000-00008","article-title":"Effect of intraoperative fluid management on outcome after intraabdominal surgery","volume":"103","author":"Nisanevich","year":"2005","journal-title":"Anesthesiology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/bja\/ael290","article-title":"Wet, dry or something else?","volume":"97","author":"Bellamy","year":"2006","journal-title":"Br. J. Anaesth."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1213\/01.ANE.0000148691.33690.AC","article-title":"Perioperative fluid management and clinical outcomes in adults","volume":"100","author":"Grocott","year":"2005","journal-title":"Anesth. Analg."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1159\/000248164","article-title":"Volume therapy and cardiocircular function during hyperthermic intraperitoneal chemotherapy","volume":"43","author":"Raue","year":"2009","journal-title":"Eur. Surg. Res."},{"key":"ref_33","first-page":"131","article-title":"The use of cardiac output monitoring to guide the administration of intravenous fluid during hyperthermic intraperitoneal chemotherapy","volume":"16","author":"Thanigaimani","year":"2014","journal-title":"Color. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1007\/s11605-015-2743-1","article-title":"A randomized trial of goal directed vs. standard fluid therapy in cytoreductive surgery with hyperthermic intraperitoneal chemotherapy","volume":"19","author":"Colantonio","year":"2015","journal-title":"J. Gastrointest. Surg."},{"key":"ref_35","first-page":"358","article-title":"The Global End-Diastolic Volume Could Be More Appropriate to Fluid Management Than Central Venous Pressure During Closed Hyperthermic Intrabdominal Chemotherapy with CO2 Circulation","volume":"30","author":"Redondo","year":"2017","journal-title":"J. Investig. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1001\/jamasurg.2017.2865","article-title":"Association of Fluid Administration With Morbidity in Cytoreductive Surgery With Hyperthermic Intraperitoneal Chemotherapy","volume":"152","author":"Eng","year":"2017","journal-title":"JAMA Surg."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jss.2018.05.015","article-title":"Intraoperative fluid restriction in hyperthermic intraperitoneal chemotherapy","volume":"231","author":"Almerey","year":"2018","journal-title":"J. Surg. Res."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1245\/s10434-018-07092-y","article-title":"Restrictive Intraoperative Fluid Therapy is Associated with Decreased Morbidity and Length of Stay Following Hyperthermic Intraperitoneal Chemoperfusion","volume":"26","author":"Hendrix","year":"2019","journal-title":"Ann. Surg. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"300060520983263","DOI":"10.1177\/0300060520983263","article-title":"Physiologic and hemodynamic changes in patients undergoing open abdominal cytoreductive surgery with hyperthermic intraperitoneal chemotherapy","volume":"49","author":"Kim","year":"2021","journal-title":"J. Int. Med. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"8939","DOI":"10.1245\/s10434-021-10672-0","article-title":"Restrictive Intraoperative Fluid Rate is Associated with Improved Outcomes in Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy","volume":"28","author":"Peng","year":"2021","journal-title":"Ann. Surg. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"107118","DOI":"10.1016\/j.ejso.2023.03.003","article-title":"The impact on postoperative outcomes of intraoperative fluid management strategies during cytoreductive surgery and hyperthermic intraperitoneal chemotherapy","volume":"49","author":"Dranichnikov","year":"2023","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e38187","DOI":"10.1097\/MD.0000000000038187","article-title":"The management of goal-directed fluid therapy during cytoreductive surgery and hyperthermic intraperitoneal chemotherapy","volume":"103","author":"Tuncel","year":"2024","journal-title":"Medicine"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1016\/j.ejso.2020.07.041","article-title":"Guidelines for Perioperative Care in Cytoreductive Surgery (CRS) with or without hyperthermic IntraPEritoneal chemotherapy (HIPEC): Enhanced recovery after surgery (ERAS\u00ae) Society Recommendations\u2014Part I: Preoperative and intraoperative management","volume":"46","author":"Kusamura","year":"2020","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1097\/SLA.0b013e31825a2f22","article-title":"Perioperative fluid administration: Historical highlights and implications for practice","volume":"256","author":"Srinivasa","year":"2012","journal-title":"Ann. Surg."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.bja.2021.10.046","article-title":"Goal-directed haemodynamic therapy during general anaesthesia for noncardiac surgery: A systematic review and meta-analysis","volume":"128","author":"Jessen","year":"2022","journal-title":"Br. J. Anaesth."},{"key":"ref_46","first-page":"531","article-title":"Haemodynamic management during hyperthermic intraperitoneal chemotherapy: A systematic review","volume":"39","author":"Bezu","year":"2020","journal-title":"Anaesth. Crit. Care Pain Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/bja\/aes301","article-title":"Ability of stroke volume variation measured by oesophageal Doppler monitoring to predict fluid responsiveness during surgery","volume":"110","author":"Guinot","year":"2013","journal-title":"Br. J. Anaesth."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1213\/ANE.0000000000001239","article-title":"Should Norepinephrine, Rather than Phenylephrine, Be Considered the Primary Vasopressor in Anesthetic Practice?","volume":"122","author":"Mets","year":"2016","journal-title":"Anesth. Analg."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/aas.12905","article-title":"Norepinephrine reduces arterial compliance less than phenylephrine when treating general anesthesia-induced arterial hypotension","volume":"61","author":"Passouant","year":"2017","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1213\/ANE.0000000000005811","article-title":"Low-Concentration Norepinephrine Infusion for Major Surgery: A Safety and Feasibility Pilot Randomized Controlled Trial","volume":"134","author":"Aykanat","year":"2022","journal-title":"Anesth. Analg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bja.2023.02.004","article-title":"Norepinephrine versus phenylephrine for treating hypotension during general anaesthesia in adult patients undergoing major noncardiac surgery: A multicentre, open-label, cluster-randomised, crossover, feasibility, and pilot trial","volume":"130","author":"Legrand","year":"2023","journal-title":"Br. J. Anaesth."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s44158-025-00225-2","article-title":"Single center experience with Hypotension Prediction Index (HPI) during cytoreductive surgery with Hyperthermic Intraperitoneal Chemotherapy (HIPEC)","volume":"5","author":"Frassanito","year":"2025","journal-title":"J. Anesth. Analg. Crit. Care"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"631","DOI":"10.23736\/S0375-9393.25.18937-2","article-title":"Personalized predictive hemodynamic management for major oncologic surgery: Effect of progressive implementation of monitoring of digital medical devices with artificial intelligence-based algorithms","volume":"91","author":"Pasta","year":"2025","journal-title":"Minerva Anestesiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s44158-026-00354-2","article-title":"Implementation and learning curve in AI-assisted fluid management during abdominal oncologic surgery: A retrospective observational study","volume":"6","author":"Pasta","year":"2026","journal-title":"J. Anesth. Analg. Crit. Care"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1681\/ASN.2004090740","article-title":"Acute kidney injury, mortality, length of stay, and costs in hospitalized patients","volume":"16","author":"Chertow","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"2420835","DOI":"10.1080\/0886022X.2024.2420835","article-title":"Intraoperative hyperthermia is associated with increased acute kidney injury following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A retrospective cohort study","volume":"46","author":"Gao","year":"2024","journal-title":"Ren. Fail."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2338482","DOI":"10.1080\/0886022X.2024.2338482","article-title":"Incidence, risk factors, and outcomes of the transition of HIPEC-induced acute kidney injury to acute kidney disease: A retrospective study","volume":"46","author":"Lu","year":"2024","journal-title":"Ren. Fail."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.3109\/0886022X.2014.949758","article-title":"The incidence of cisplatin nephrotoxicity post hyperthermic intraperitoneal chemotherapy (HIPEC) and cytoreductive surgery","volume":"36","author":"Hakeam","year":"2014","journal-title":"Ren. Fail."},{"key":"ref_59","first-page":"1621","article-title":"Hyperthermic intraperitoneal chemotherapy with cisplatin: Amifostine prevents acute severe renal impairment","volume":"41","author":"Bouhadjari","year":"2015","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.ejso.2015.12.016","article-title":"Assessment of RIFLE and AKIN criteria to define acute renal dysfunction for HIPEC procedures for ovarian and non-ovarian malignancies","volume":"42","year":"2016","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1080\/02656736.2017.1293304","article-title":"Acute kidney injury in ovarian cancer patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy","volume":"33","author":"Sin","year":"2017","journal-title":"Int. J. Hyperth."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/02656736.2018.1526416","article-title":"Effect of intraoperative dexmedetomidine on renal function after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A randomized, placebo-controlled trial","volume":"36","author":"Song","year":"2019","journal-title":"Int. J. Hyperth."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1080\/02656736.2019.1597175","article-title":"Assessment of nephrotoxicity associated with combined cisplatin and mitomycin C usage in laparoscopic hyperthermic intraperitoneal chemotherapy","volume":"36","author":"Kapoor","year":"2019","journal-title":"Int. J. Hyperth."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1080\/02656736.2020.1795277","article-title":"Sodium thiosulfate protects from renal impairement following hyperthermic intraperitoneal chemotherapy (HIPEC) with Cisplatin","volume":"37","author":"Laplace","year":"2020","journal-title":"Int. J. Hyperth."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1080\/02656736.2020.1846793","article-title":"Risk factors of acute renal impairment after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy","volume":"37","author":"Chen","year":"2020","journal-title":"Int. J. Hyperth."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"100796","DOI":"10.1016\/j.gore.2021.100796","article-title":"The addition of sodium thiosulphate to hyperthermic intraperitoneal chemotherapy with cisplatin in ovarian cancer","volume":"37","author":"Glennon","year":"2021","journal-title":"Gynecol. Oncol. Rep."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Zaballos, M., Power, M., Canal-Alonso, M.I., Gonz\u00e1lez-Nicol\u00e1s, M.\u00c1., Vasquez-Jimenez, W., Lozano-Lominchar, P., Cabrerizo-Torrente, P., Palencia-Garc\u00eda, N., Gago-Quiroga, S., and Ginel-Feito, M.D. (2021). Effect of Cilastatin on Cisplatin-Induced Nephrotoxicity in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22031239"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1245\/s10434-021-10508-x","article-title":"Sodium Thiosulfate Reduces Acute Kidney Injury in Patients Undergoing Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy with Cisplatin: A Single-Center Observational Study","volume":"29","author":"Kurreck","year":"2022","journal-title":"Ann. Surg. Oncol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"6630","DOI":"10.1038\/s41598-024-54979-w","article-title":"Development of a predictive model for risk stratification of acute kidney injury in patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy","volume":"14","author":"Krause","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2304250","DOI":"10.1080\/02656736.2024.2304250","article-title":"Risk factors of chronic kidney disease in cisplatin-based hyperthermia intraperitoneal chemotherapy","volume":"41","author":"Cheng","year":"2024","journal-title":"Int. J. Hyperth."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1097\/ALN.0000000000005711","article-title":"Effect of Urine-guided Intraoperative Hydration on Incidence of Acute Kidney Injury after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei: A Randomized Trial","volume":"143","author":"Gao","year":"2025","journal-title":"Anesthesiology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ygyno.2026.03.012","article-title":"Evaluating alternative protocols for preventing cisplatin-induced acute kidney injury during hyperthermic intraperitoneal chemotherapy in ovarian cancer","volume":"208","author":"Lee","year":"2026","journal-title":"Gynecol. Oncol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00423-023-02948-8","article-title":"Influence of hyperthermic intraperitoneal chemotherapy on renal blood perfusion","volume":"408","author":"Liesenfeld","year":"2023","journal-title":"Langenbecks Arch. Surg."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1080\/02656736.2017.1368096","article-title":"Identification of risk factors associated with postoperative acute kidney injury after cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: A retrospective study","volume":"34","author":"Cata","year":"2018","journal-title":"Int. J. Hyperth."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.amsu.2018.09.036","article-title":"Acute kidney injury increases the rate of major morbidities in cytoreductive surgery and HIPEC","volume":"26","author":"Naffouje","year":"2018","journal-title":"Ann. Med. Surg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1245\/s10434-022-12661-3","article-title":"Extensive peritonectomy is an independent risk factor for cisplatin hipec-induced acute kidney injury","volume":"30","author":"Liesenfeld","year":"2023","journal-title":"Ann. Surg. Oncol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1097\/CCM.0b013e3181a5906f","article-title":"Incidence and outcomes of acute kidney injury in intensive care units: A Veterans Administration study","volume":"37","author":"Thakar","year":"2009","journal-title":"Crit. Care Med."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Grillo-Mar\u00edn, C., Ant\u00f3n-Rodr\u00edguez, C., Prieto, L., Ortega-P\u00e9rez, G., and Gonz\u00e1lez-Moreno, S. (2024). Nephrotoxicity associated with cytoreductive surgery combined with cisplatin-based hyperthermic intraperitoneal chemotherapy for peritoneal malignant disease: A systematic review and meta-analysis. J. Clin. Med., 13.","DOI":"10.3390\/jcm13133793"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"108622","DOI":"10.1016\/j.ejso.2024.108622","article-title":"Acute kidney injury after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy\u2014A systematic review","volume":"50","author":"Solanki","year":"2024","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Dugbartey, G.J., Alornyo, K.K., Adams, I., Adjei, S., Amoah, D., and Obeng-Kyeremeh, R. (2025). Chemoprotective Mechanism of Sodium Thiosulfate Against Cisplatin-Induced Nephrotoxicity Is via Renal Hydrogen Sulfide, Arginine\/cAMP and NO\/cGMP Signaling Pathways. Int. J. Mol. Sci., 26.","DOI":"10.3390\/ijms26010384"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"107955","DOI":"10.1016\/j.ejso.2024.107955","article-title":"Eliminating the need for preoperative intravenous hyperhydration: Sodium thiosulfate as nephrotoxicity prevention in HIPEC-treated patients\u2014A retrospective analysis","volume":"50","author":"Vachez","year":"2024","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"e23786","DOI":"10.1002\/jbt.23786","article-title":"VALD-2 mitigates cisplatin-induced acute kidney injury: Mechanistic insights into oxidative stress modulation and inflammation suppression","volume":"38","author":"Zhao","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1124\/jpet.110.165779","article-title":"Cilastatin attenuates cisplatin-induced proximal tubular cell damage","volume":"334","author":"Lazaro","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1093\/ndt\/gfx005","article-title":"Cisplatin-induced renal inflammation is ameliorated by cilastatin nephroprotection","volume":"32","author":"Humanes","year":"2017","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.3892\/mmr.2014.2034","article-title":"Molecular targets and mechanism of action of dexmedetomidine in treatment of ischemia\/reperfusion injury","volume":"9","author":"Cai","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jclinane.2017.03.053","article-title":"The effect of dexmedetomidine on renal function in patients undergoing cardiac valve replacement under cardiopulmonary bypass: A double-blind randomized controlled trial","volume":"40","author":"Zhai","year":"2017","journal-title":"J. Clin. Anesth."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.ejso.2023.02.015","article-title":"Perioperative nutritional assessment and interventions in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC): A systematic review","volume":"49","author":"Gearing","year":"2023","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"467","DOI":"10.7326\/M18-0850","article-title":"PRISMA Extension for Scoping Reviews (PRISMAScR): Checklist and Explanation","volume":"169","author":"Tricco","year":"2018","journal-title":"Ann. Intern. Med."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/18\/7307\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:33:24Z","timestamp":1790076804000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/18\/7307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,20]]},"references-count":88,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["jcm15187307"],"URL":"https:\/\/doi.org\/10.3390\/jcm15187307","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,20]]}}}