{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T12:10:28Z","timestamp":1790079028961,"version":"4.0.1"},"reference-count":129,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Mastectomy with immediate breast reconstruction (IBR) has become increasingly common, driven by advances in mastectomy techniques and the growing number of autologous, implant-based, and hybrid reconstructive options. The expansion of reconstructive strategies has introduced greater complexity in surgical planning and outcomes. Postoperative outcomes are influenced not only by mastectomy-related complications but also by complications specific to each reconstructive technique. Consequently, each combination of mastectomy and reconstructive modality carries unique benefits, limitations, and complication profiles that must be evaluated in the context of patient-specific factors, such as comorbidities, oncologic treatment, and reconstructive goals. This narrative review aims to characterize complication profiles associated with mastectomy and IBR to support improved perioperative management and individualized surgical care. To enhance clinical utility, this review includes representative clinical images that demonstrate variability in complication presentation across surgical approaches and patient contexts. This review presents a framework for understanding the factors that influence patient candidacy and outcomes in the setting of mastectomy with IBR, thereby supporting improved risk stratification and tailored treatment algorithms.<\/jats:p>","DOI":"10.3390\/jcm15187334","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:09:35Z","timestamp":1790075375000},"page":"7334","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Technique-Driven and Patient-Specific Variations in Complications of Mastectomy with Immediate Breast Reconstruction: An Evidence-Based Review"],"prefix":"10.3390","volume":"15","author":[{"given":"Lamorna","family":"Coyle","sequence":"first","affiliation":[{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Hempstead, NY 11042, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8582-1743","authenticated-orcid":false,"given":"Gabrielle","family":"Odoom","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Northwell Health, Great Neck, NY 11021, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You Jeong","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Northwell Health, Great Neck, NY 11021, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"Division of Plastic and Reconstructive Surgery, Northwell Health, Great Neck, NY 11021, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Ricci","sequence":"additional","affiliation":[{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Hempstead, NY 11042, USA"},{"name":"Division of Plastic and Reconstructive Surgery, Northwell Health, Great Neck, NY 11021, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Tanna","sequence":"additional","affiliation":[{"name":"Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Hempstead, NY 11042, USA"},{"name":"Division of Plastic and Reconstructive Surgery, Northwell Health, Great Neck, NY 11021, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"10528","DOI":"10.1200\/JCO.2023.41.16_suppl.10528","article-title":"Breast cancer: Global patterns of incidence, mortality, and trends","volume":"41","author":"Sedeta","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"ref_2","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","unstructured":"(2026, March 08). Breastcancer.org. Breast Cancer Facts & Statistics. Available online: https:\/\/www.breastcancer.org\/facts-statistics."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7S","DOI":"10.1097\/PRS.0000000000003941","article-title":"Current Trends in Postmastectomy Breast Reconstruction","volume":"140","author":"Panchal","year":"2017","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/ajm.AJM_21_18","article-title":"Prophylactic mastectomy for the prevention of breast cancer: Review of the literature","volume":"8","author":"Alaofi","year":"2018","journal-title":"Avicenna J. Med."},{"key":"ref_6","first-page":"901046","article-title":"Contralateral risk-reducing mastectomy: Review of risk factors and risk-reducing strategies","volume":"2015","author":"Basu","year":"2015","journal-title":"Int. J. Surg. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1097\/PRS.0000000000001276","article-title":"Bilateral Mastectomy versus Breast-Conserving Surgery for Early-Stage Breast Cancer","volume":"135","author":"Albornoz","year":"2015","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/PSN.0000000000000205","article-title":"Met and Unmet Expectations for Breast Reconstruction in Early Posttreatment Breast Cancer Survivors","volume":"37","author":"Steffen","year":"2017","journal-title":"Plast. Surg. Nurs."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1245\/s10434-011-1580-z","article-title":"Disparities in Reconstruction Rates After Mastectomy: Patterns of Care and Factors Associated with the Use of Breast Reconstruction in Southern California","volume":"18","author":"Kruper","year":"2011","journal-title":"Ann. Surg. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/SLA.0b013e3182263bb0","article-title":"Institutional Variation in the Surgical Treatment of Breast Cancer","volume":"254","author":"Greenberg","year":"2011","journal-title":"Ann. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1001\/jamasurg.2014.548","article-title":"Access to Breast Reconstruction After Mastectomy and Patient Perspectives on Reconstruction Decision Making","volume":"149","author":"Morrow","year":"2014","journal-title":"JAMA Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/PRS.0b013e3182729cde","article-title":"A Paradigm Shift in U.S. Breast Reconstruction: Increasing Implant Rates","volume":"131","author":"Albornoz","year":"2013","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.amjsurg.2021.02.014","article-title":"National trends and predictors of mastectomy with immediate breast reconstruction","volume":"222","author":"Mandelbaum","year":"2021","journal-title":"Am. J. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1097\/SAP.0000000000001045","article-title":"Management of Mastectomy Skin Necrosis in Implant Based Breast Reconstruction","volume":"78","author":"Sue","year":"2017","journal-title":"Ann. Plast. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1097\/PRS.0b013e31820436fa","article-title":"Effect of Intraoperative Saline Fill Volume on Perioperative Outcomes in Tissue Expander Breast Reconstruction","volume":"127","author":"Crosby","year":"2011","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1245\/s10434-015-4709-7","article-title":"Skin Flap Necrosis After Mastectomy With Reconstruction: A Prospective Study","volume":"23","author":"Matsen","year":"2016","journal-title":"Ann. Surg. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e2280","DOI":"10.1097\/GOX.0000000000002280","article-title":"Ischemic Complications after Nipple-sparing Mastectomy: Predictors of Reconstructive Failure in Implant-based Reconstruction and Implications for Decision-making","volume":"7","author":"Salibian","year":"2019","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejso.2011.10.007","article-title":"Nipple sparing mastectomy: Can we predict the factors predisposing to necrosis?","volume":"38","author":"Algaithy","year":"2012","journal-title":"Eur. J. Surg. Oncol. EJSO"},{"key":"ref_19","first-page":"e40631","article-title":"The Duration of Postoperative Antibiotics in Autologous Breast Reconstruction: A Systematic Review and Meta-Analysis","volume":"15","author":"Aldarragi","year":"2023","journal-title":"Cureus"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2022\/7857158","article-title":"Morbidity of the Donor Site and Complication Rates of Breast Reconstruction with Autologous Abdominal Flaps: A Systematic Review and Meta-Analysis","volume":"2022","author":"Mortada","year":"2022","journal-title":"Breast J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"416","DOI":"10.21037\/atm-23-1384","article-title":"Management of complications following implant-based breast reconstruction: A narrative review","volume":"11","author":"Meshkin","year":"2023","journal-title":"Ann. Transl. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1007\/s00266-021-02362-9","article-title":"Dermatologic Complications Following Cosmetic and Reconstructive Plastic Surgery: A Systematic Review of the Literature","volume":"45","author":"Nicksic","year":"2021","journal-title":"Aesthet. Plast. Surg."},{"key":"ref_23","first-page":"133","article-title":"Minimizing incisional dehiscence following 2-stage prosthetic breast reconstruction in the setting of radiation therapy","volume":"2","author":"Nahabedian","year":"2013","journal-title":"Gland Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/micr.21948","article-title":"Bilateral autologous breast reconstruction with deep inferior epigastric artery perforator flaps: Review of a single surgeon\u2019s early experience","volume":"32","author":"Venkat","year":"2012","journal-title":"Microsurgery"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1097\/SAP.0000000000000400","article-title":"Effects of Obesity on Postoperative Complications After Breast Reconstruction Using Free Muscle-Sparing Transverse Rectus Abdominis Myocutaneous, Deep Inferior Epigastric Perforator, and Superficial Inferior Epigastric Artery Flap","volume":"76","author":"Lee","year":"2016","journal-title":"Ann. Plast. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e4693","DOI":"10.1097\/GOX.0000000000004693","article-title":"Predictors of Complications after Breast Reconstruction Surgery: A Systematic Review and Meta-analysis","volume":"10","author":"Mrad","year":"2022","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jtv.2018.08.005","article-title":"The effect of postoperative closed incision negative pressure therapy on the incidence of donor site wound dehiscence in breast reconstruction patients: DEhiscence PREvention Study (DEPRES), pilot randomized controlled trial","volume":"27","author":"Hummelink","year":"2018","journal-title":"J. Tissue Viability"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1097\/PRS.0b013e318230c29e","article-title":"Acellular Dermis\u2013Assisted Prosthetic Breast Reconstruction: A Systematic and Critical Review of Efficacy and Associated Morbidity","volume":"128","author":"Sbitany","year":"2011","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.21873\/anticanres.15349","article-title":"Difficulties of Breast Reconstruction\u2014Problems That No One Likes to Face","volume":"41","author":"Friedrich","year":"2021","journal-title":"Anticancer Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1097\/01.PRS.0000110328.47206.50","article-title":"A 10-Year Retrospective Review of 758 DIEP Flaps for Breast Reconstruction","volume":"113","author":"Gill","year":"2004","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1002\/micr.30473","article-title":"Risk factors and timing of postoperative hematomas following microvascular breast reconstruction: A prospective cohort study","volume":"40","author":"Phan","year":"2019","journal-title":"Microsurgery"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jamcollsurg.2016.01.050","article-title":"Effect of Noninfectious Wound Complications after Mastectomy on Subsequent Surgical Procedures and Early Implant Loss","volume":"222","author":"Nickel","year":"2016","journal-title":"J. Am. Coll. Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/01.sap.0000201549.83738.42","article-title":"Complications Associated With Breast Reconstruction Using a Perforator Flap Compared With a Free TRAM Flap","volume":"56","author":"Scheer","year":"2006","journal-title":"Ann. Plast. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/PRS.0b013e3182361fd6","article-title":"A Meta-Analysis of Human Acellular Dermis and Submuscular Tissue Expander Breast Reconstruction","volume":"129","author":"Kim","year":"2012","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/SAP.0b013e318243355f","article-title":"Hematoma After Mastectomy With Immediate Reconstruction An Analysis of Risk Factors in 883 Patients","volume":"71","author":"Seth","year":"2013","journal-title":"Ann. Plast. Surg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/micr.30845","article-title":"Management of postoperative microvascular compromise and ischemia reperfusion injury in breast reconstruction using autologous tissue transfer: Retrospective review of 2103 flaps","volume":"42","author":"Coriddi","year":"2021","journal-title":"Microsurgery"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/micr.22151","article-title":"A systematic approach to emergent breast free flap takeback: Clinical outcomes, algorithm, and review of the literature","volume":"33","author":"Khansa","year":"2013","journal-title":"Microsurgery"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1016\/j.bjps.2020.12.044","article-title":"Abdominal weakness, bulge, or hernia after DIEP flaps: An algorithm of management, prevention, and surgical repair with classification","volume":"74","author":"Haddock","year":"2021","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e7407","DOI":"10.1097\/GOX.0000000000007407","article-title":"Understanding Capsular Contracture: Mechanisms, Management, and Patient Outcomes in Implant-based Breast Augmentation and Reconstruction","volume":"14","author":"Clark","year":"2026","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.4048\/jbc.2023.26.e7","article-title":"Complications Including Capsular Contracture in Direct-to-Implant Breast Reconstruction With Textured Anatomical Versus Smooth Round Implants: A Single Center Retrospective Analysis","volume":"26","author":"Jeon","year":"2023","journal-title":"J. Breast Cancer"},{"key":"ref_41","unstructured":"Szymanski, K.D., and Mikes, B.A. (2026, March 09). Breast Implant Rupture, StatPearls, Available online: http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK459308\/."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"692e","DOI":"10.1097\/PRS.0000000000000607","article-title":"Analysis of Risk Factors for Complications in Expander\/Implant Breast Reconstruction by Stage of Reconstruction","volume":"134","author":"Hirsch","year":"2014","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1182\/bloodadvances.2025016810","article-title":"BRCA1\/2 impact on the development of implant-associated lymphoma in women with breast cancer and textured implants","volume":"9","author":"Ghione","year":"2025","journal-title":"Blood Adv."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/asj\/sjw264","article-title":"The Impact of Animation Deformity on Quality of Life in Post-Mastectomy Reconstruction Patients","volume":"37","author":"Becker","year":"2017","journal-title":"Aesthet. Surg. J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"437e","DOI":"10.1097\/PRS.0000000000008229","article-title":"Understanding the Evidence and Improving Outcomes with Implant-Based Prepectoral Breast Reconstruction","volume":"148","author":"Campbell","year":"2021","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/01.GOX.0000584300.68370.2d","article-title":"Correction of Implant Malposition in Breast Reconstruction: Risk Factors and Outcomes","volume":"7","author":"Fracol","year":"2019","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"e3433","DOI":"10.1097\/GOX.0000000000003433","article-title":"Post-mastectomy Breast Reconstruction with Autologous Tissue: Current Methods and Techniques","volume":"9","author":"Garza","year":"2021","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"111e","DOI":"10.1097\/PRS.0000000000007480","article-title":"Latest Advancements in Autologous Breast Reconstruction","volume":"147","author":"Chang","year":"2020","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Sinik, L.M., and Collins, M.S. (2024). Challenges in Autologous Breast Reconstruction: A Review of Recommendations. J. Clin. Med., 13.","DOI":"10.3390\/jcm13040971"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"3S","DOI":"10.1097\/PRS.0000000000010490","article-title":"Surgical Outcomes of Autologous Breast Reconstruction in Low Body Mass Index Patients: Beyond the Standard DIEP Flap","volume":"152","author":"Haddock","year":"2023","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"106197","DOI":"10.1016\/j.jinf.2024.106197","article-title":"Reconstructive breast implant\u2013related infections: Prevention, diagnosis, treatment, and pearls of wisdom","volume":"89","author":"Perez","year":"2024","journal-title":"J. Infect."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1245\/s10434-022-12567-0","article-title":"Prepectoral Versus Subpectoral Implant-Based Breast Reconstruction: A Systemic Review and Meta-analysis","volume":"30","author":"Ostapenko","year":"2022","journal-title":"Ann. Surg. Oncol."},{"key":"ref_53","first-page":"e18","article-title":"Optimizing Outcomes of Postmastectomy Breast Reconstruction With Acellular Dermal Matrix: A Review of Recent Clinical Data","volume":"17","author":"Zenn","year":"2017","journal-title":"Eplasty"},{"key":"ref_54","first-page":"CD013821","article-title":"Implants versus autologous tissue flaps for breast reconstruction following mastectomy","volume":"2024","author":"Rocco","year":"2024","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Rothchild, E., Smith, I.T., Odoom, G., Smith, M.L., and Tanna, N. (2025). Revolutionizing Breast Reconstruction: The Rise of Hybrid Techniques. Medicina, 61.","DOI":"10.3390\/medicina61081434"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"e1625","DOI":"10.1097\/GOX.0000000000001625","article-title":"Complications following Nipple-Sparing Mastectomy and Immediate Acellular Dermal Matrix Implant-based Breast Reconstruction\u2014A Systematic Review and Meta-analysis","volume":"6","author":"Heidemann","year":"2018","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.clbc.2026.01.014","article-title":"Microsurgery on Steroids: The Impact of Chronic Immunosuppressive Therapy on Outcomes Following Free Flap Breast Reconstruction","volume":"26","author":"Knoedler","year":"2026","journal-title":"Clin. Breast Cancer"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2147\/BCTT.S81712","article-title":"Mastectomy skin flap necrosis: Challenges and solutions","volume":"9","author":"Robertson","year":"2017","journal-title":"Breast Cancer Targets Ther."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1161\/CIRCULATIONAHA.107.763730","article-title":"Impaired Tissue Perfusion: A Pathology Common to Hypertension, Obesity, and Diabetes Mellitus","volume":"118","author":"Levy","year":"2008","journal-title":"Circulation"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1016\/j.bjps.2022.02.053","article-title":"Impact of diabetes on outcomes in breast reconstruction: A systematic review and meta-analysis","volume":"75","author":"Liu","year":"2022","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Rupra, R.S., Ruccia, F., Daneshi, K., Aftab, F., Yousif, Y.F., Khan, G.R., Dehnadi, S., AlSaidi, Y.H., Maggialetti, N., and Lorusso, G. (2025). A systematic review and meta-analysis on computed tomography angiography mapping for deep inferior epigastric perforator flap breast reconstruction. Front. Oncol., 15.","DOI":"10.3389\/fonc.2025.1600476"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.bjps.2017.05.012","article-title":"Post-reconstruction dermatitis of the breast","volume":"70","author":"Rosen","year":"2017","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1177\/22925503231169776","article-title":"Recurrent Allergic Contact Dermatitis to Bacitracin Used in Pocket Irrigation During Breast Reconstruction Surgery","volume":"32","author":"Liu","year":"2023","journal-title":"Plast. Surg."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1055\/s-0042-1751103","article-title":"Comparing Seroma Formation at the Deep Inferior Epigastric Perforator, Transverse Musculocutaneous Gracilis, and Superior Gluteal Artery Perforator Flap Donor Sites after Microsurgical Breast Reconstruction","volume":"49","author":"Merchant","year":"2022","journal-title":"Arch. Plast. Surg."},{"key":"ref_65","first-page":"295","article-title":"Prophylactic Venous Supercharging in Deep Inferior Epigastric Artery Perforator Flap Surgery: A Retrospective Dual-Center Study","volume":"41","author":"Lombardo","year":"2024","journal-title":"J. Reconstr. Microsurg."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1016\/j.bjps.2018.05.022","article-title":"Risk factors for developing capsular contracture in women after breast implant surgery: A systematic review of the literature","volume":"71","author":"Bachour","year":"2018","journal-title":"J. Plast. Reconstr. Aesthet. Surg."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/jjco\/hyl019","article-title":"Evidence-Based Risk Factors for Seroma Formation in Breast Surgery","volume":"36","author":"Kuroi","year":"2006","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/SAP.0000000000003573","article-title":"Seroma After Breast Reconstruction With Tissue Expanders","volume":"91","author":"Ozturk","year":"2023","journal-title":"Ann. Plast. Surg."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1245\/s10434-016-5201-8","article-title":"Protecting Nipple Perfusion by Devascularization and Surgical Delay in Patients at Risk for Ischemic Complications During Nipple-Sparing Mastectomies","volume":"23","author":"Bertoni","year":"2016","journal-title":"Ann. Surg. Oncol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/SLA.0b013e31818e41a7","article-title":"Total Skin-Sparing Mastectomy: Complications and Local Recurrence Rates in 2 Cohorts of Patients","volume":"249","author":"Garwood","year":"2009","journal-title":"Ann. Surg."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1007\/s00268-018-4852-y","article-title":"Risk Factors for Skin Flap Necrosis in Breast Cancer Patients Treated with Mastectomy Followed by Immediate Breast Reconstruction","volume":"43","author":"Ito","year":"2018","journal-title":"World J. Surg."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1159\/000512201","article-title":"Human Acellular Dermal Matrix (Epiflex\u00ae) in Immediate Implant-Based Breast Reconstruction after Skin- and Nipple-Sparing Mastectomy and Treatment of Capsular Fibrosis: Results of a Multicenter, Prospective, Observational NOGGO-AWOGyn Study","volume":"16","author":"Beier","year":"2020","journal-title":"Breast Care"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/209458","article-title":"Nummular Eczema of Breast: A Potential Dermatologic Complication after Mastectomy and Subsequent Breast Reconstruction","volume":"2015","author":"Iwahira","year":"2015","journal-title":"Plast. Surg. Int."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jamcollsurg.2008.04.021","article-title":"Risk Factors for Surgical Site Infection after Major Breast Operation","volume":"207","author":"Olsen","year":"2008","journal-title":"J. Am. Coll. Surg."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1007\/s00266-015-0555-z","article-title":"A Meta-analysis of Postoperative Complications of Tissue Expander\/Implant Breast Reconstruction Using Acellular Dermal Matrix","volume":"39","author":"Zhao","year":"2015","journal-title":"Aesthet. Plast. Surg."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.idc.2018.06.007","article-title":"Breast Implant Infections","volume":"32","author":"Lalani","year":"2018","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Lisa, A.V.E., Zeneli, F., Mazzucco, M., Barbieri, B., Rietjens, M., Lissidini, G., Vinci, V., Bartoletti, M., Belati, A., and Bavaro, D. (2024). Microbiology of periprosthetic infections following implant-based breast reconstruction surgery: A multicentric retrospective study. Front. Surg., 11.","DOI":"10.3389\/fsurg.2024.1477023"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1128\/CMR.00092-13","article-title":"Propionibacterium acnes: From commensal to opportunistic biofilm-associated implant pathogen","volume":"27","author":"Achermann","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1007\/s00266-021-02702-9","article-title":"Review of Early Signs of Breast Implant Infection","volume":"46","author":"Zhang","year":"2022","journal-title":"Aesthet. Plast. Surg."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1093\/asj\/sjad285","article-title":"Tension Reduction With Force Modulating Tissue Bridges Reduces Wounds in Breast Surgery","volume":"43","author":"Wall","year":"2023","journal-title":"Aesthet. Surg. J."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"10016","DOI":"10.1038\/s41598-022-13831-9","article-title":"Prevention of lymphocele or seroma after mastectomy and axillary lymphadenectomy for breast cancer: Systematic review and meta-analysis","volume":"12","author":"Adrien","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1177\/000313480006600505","article-title":"Seroma Formation after Breast Cancer Surgery: Incidence and Predicting Factors","volume":"66","author":"Woodworth","year":"2000","journal-title":"Am. Surg."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1097\/01.prs.0000481102.24444.72","article-title":"Seroma in Prosthetic Breast Reconstruction","volume":"137","author":"Jordan","year":"2016","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.suc.2021.06.014","article-title":"Breast surgery: Management of postoperative complications following operations for breast cancer","volume":"101","author":"Wilkerson","year":"2021","journal-title":"Surg. Clin. N. Am."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1080\/0284186X.2023.2203831","article-title":"Risk factors for seroma formation after axillary lymph node dissection with special focus on the impact of early shoulder exercise","volume":"62","author":"Borg","year":"2023","journal-title":"Acta Oncol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1245\/s10434-015-4741-7","article-title":"Reoperation for Complications after Lumpectomy and Mastectomy for Breast Cancer from the 2012 National Surgical Quality Improvement Program (ACS-NSQIP)","volume":"22","author":"Thomsen","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"413e","DOI":"10.1097\/PRS.0b013e3182402ce0","article-title":"Incidence of Breast Hematoma after Placement of Breast Prostheses","volume":"129","author":"Collins","year":"2012","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"33","DOI":"10.20517\/2347-9264.2022.146","article-title":"Strategies for prevention and management of partial flap loss or fat necrosis in microvascular autologous breast reconstruction","volume":"10","author":"Cheng","year":"2023","journal-title":"Plast. Aesthet. Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1097\/SCS.0000000000003026","article-title":"Risk Factors Leading to Free Flap Failure","volume":"27","author":"Massenburg","year":"2016","journal-title":"J. Craniofacial Surg."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1e","DOI":"10.1097\/PRS.0000000000006888","article-title":"Intraoperative Assessment of DIEP Flap Breast Reconstruction Using Indocyanine Green Angiography: Reduction of Fat Necrosis, Resection Volumes, and Postoperative Surveillance","volume":"146","author":"Hembd","year":"2020","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1007\/s00266-020-01784-1","article-title":"Fat Necrosis After DIEP Flap Breast Reconstruction: A Review of Perfusion-Related Causes","volume":"44","author":"Bhullar","year":"2020","journal-title":"Aesthet. Plast. Surg."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1097\/PRS.0b013e31827c6dc2","article-title":"Fat Necrosis in Autologous Abdomen-Based Breast Reconstruction","volume":"131","author":"Khansa","year":"2013","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.breast.2005.07.003","article-title":"Fat necrosis of the breast\u2014A review","volume":"15","author":"Tan","year":"2006","journal-title":"Breast"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"20180213","DOI":"10.1259\/bjr.20180213","article-title":"A pictorial review: Multimodality imaging of benign and suspicious features of fat necrosis in the breast","volume":"91","author":"Tayyab","year":"2018","journal-title":"Br. J. Radiol."},{"key":"ref_95","first-page":"tzae010","article-title":"Imaging findings after a total reconstructed breast with autologous fat transfer: What the radiologist needs to know","volume":"6","author":"Rijkx","year":"2023","journal-title":"BJR Open"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"094","DOI":"10.1055\/s-0042-1750435","article-title":"Treatment Algorithm of Postsurgical Fat Necrosis of the Breast\u2014Revisited","volume":"36","author":"Haran","year":"2022","journal-title":"Semin. Plast. Surg."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/GOX.0b013e318294e41d","article-title":"Increased Flap Weight and Decreased Perforator Number Predict Fat Necrosis in DIEP Breast Reconstruction","volume":"1","author":"Mulvey","year":"2013","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1080\/2000656X.2018.1498790","article-title":"Factors that predict deep inferior epigastric perforator flap donor site hernia and bulge","volume":"52","author":"Butler","year":"2018","journal-title":"J. Plast. Surg. Hand Surg."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/PRS.0000000000004631","article-title":"Optimizing Perforator Selection: A Multivariable Analysis of Predictors for Fat Necrosis and Abdominal Morbidity in DIEP Flap Breast Reconstruction","volume":"142","author":"Hembd","year":"2018","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1097\/PRS.0000000000005484","article-title":"Myth-Busting the DIEP Flap and an Introduction to the Abdominal Perforator Exchange (APEX) Breast Reconstruction Technique: A Single-Surgeon Retrospective Review","volume":"143","author":"DellaCroce","year":"2019","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.ejso.2017.04.008","article-title":"Subcutaneous implant breast reconstruction: Time to reconsider?","volume":"43","author":"Tasoulis","year":"2017","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"e4798","DOI":"10.1097\/GOX.0000000000004798","article-title":"Comparing Polyurethane and Acellular Dermal Matrix Implant Cover in Prepectoral Breast Reconstruction: Short-term Complications","volume":"11","author":"Poleri","year":"2023","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"75","DOI":"10.21037\/gs.2018.09.05","article-title":"Correction of animation deformity with subpectoral to prepectoral implant exchange","volume":"8","author":"Lentz","year":"2019","journal-title":"Gland Surg."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1007\/s00266-013-0221-2","article-title":"Treatment of Irradiated Expanders: Protective Lipofilling Allows Immediate Prosthetic Breast Reconstruction in the Setting of Postoperative Radiotherapy","volume":"37","author":"Ribuffo","year":"2013","journal-title":"Aesthet. Plast. Surg."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1097\/PRS.0b013e3182865d0c","article-title":"Porcine Acellular Dermal Matrix (Strattice) in Primary and Revision Cosmetic Breast Surgery","volume":"131","author":"Spear","year":"2013","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/PSN.0000000000000189","article-title":"Acellular Dermal Matrix for the Treatment and Prevention of Implant-Associated Breast Deformities","volume":"37","author":"Spear","year":"2017","journal-title":"Plast. Surg. Nurs."},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Garusi, C., and Lohsiriwat, V. (2013). Implant Exposure and Extrusion. Oncoplastic and Reconstructive Breast Surgery, Springer.","DOI":"10.1007\/978-88-470-2652-0_32"},{"key":"ref_108","first-page":"QA1","article-title":"Red Breast Syndrome: Complete Resolution Following Replacement of Acellular Dermal Matrices With Acellular Collagen Matrices","volume":"22","author":"Simpson","year":"2022","journal-title":"Eplasty"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.1097\/SAP.0000000000000130","article-title":"Delayed Hypersensitivity Reaction to Acellular Dermal Matrix in Breast Reconstruction","volume":"73","author":"Ganske","year":"2014","journal-title":"Ann. Plast. Surg."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00266-014-0444-x","article-title":"Red Breast Syndrome: A Review of Available Literature","volume":"39","author":"Wu","year":"2015","journal-title":"Aesthet. Plast. Surg."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"e2108","DOI":"10.1097\/GOX.0000000000002108","article-title":"Prosthetic Breast Reconstruction and Red Breast Syndrome: Demystification and a Review of the Literature","volume":"7","author":"Nahabedian","year":"2019","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1093\/asj\/sjae084","article-title":"Classification of Breast Implant Malposition","volume":"44","author":"Pacifico","year":"2024","journal-title":"Aesthet. Surg. J."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"e1407","DOI":"10.1097\/GOX.0000000000001407","article-title":"Animation Deformity in Postmastectomy Implant-Based Reconstruction","volume":"5","author":"Nigro","year":"2017","journal-title":"Plast. Reconstr. Surg. Glob. Open"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1097\/00006534-199909020-00009","article-title":"Analysis of Risk Factors Associated with Rupture of Silicone Gel Breast Implants","volume":"104","author":"Feng","year":"1999","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00266-024-04128-5","article-title":"A Histological Assessment Tool for Breast Implant Capsules Validated in 480 Patients with and Without Capsular Contracture","volume":"49","author":"Larsen","year":"2024","journal-title":"Aesthet. Plast. Surg."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Kubasik, M., Rzymska, A., Pi\u0119ta, B., and Rzymski, P. (2025). Ultrasound Elastography and Tonometry as Predictive Tools for Capsular Contracture After Breast Implant Surgery: Over a 12-Month Prospective Study. J. Clin. Med., 14.","DOI":"10.3390\/jcm14228084"},{"key":"ref_117","doi-asserted-by":"crossref","unstructured":"D\u2019Orsi, G., Giacalone, M., Calicchia, A., Gagliano, E., Vannucchi, L., Vanni, G., Buonomo, O.C., Cervelli, V., and Longo, B. (2024). BIA-ALCL and BIA-SCC: Updates on Clinical Features and Genetic Mutations for Latest Recommendations. Medicina, 60.","DOI":"10.3390\/medicina60050793"},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/00006534-199708000-00065","article-title":"ANAPLASTIC T-CELL LYMPHOMA IN PROXIMITY TO A SALINE-FILLED BREAST IMPLANT","volume":"100","author":"Keech","year":"1997","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_119","unstructured":"U.S. Food and Drug Administration (2026, August 03). Medical Device Reports of Breast Implant-Associated Anaplastic Large Cell Lymphoma, Available online: https:\/\/www.fda.gov\/medical-devices\/breast-implants\/medical-device-reports-breast-implant-associated-anaplastic-large-cell-lymphoma."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1097\/PRS.0000000000003282","article-title":"U.S. Epidemiology of Breast Implant\u2013Associated Anaplastic Large Cell Lymphoma","volume":"139","author":"Doren","year":"2017","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/asj\/sjw259","article-title":"NCCN Consensus Guidelines for the Diagnosis and Management of Breast Implant-Associated Anaplastic Large Cell Lymphoma","volume":"37","author":"Clemens","year":"2017","journal-title":"Aesthet. Surg. J."},{"key":"ref_122","unstructured":"(2026, August 03). National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines\u00ae): Breast Cancer, Version 6. Available online: https:\/\/www.nccn.org\/guidelines\/guidelines-detail?id=1419."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"e267232","DOI":"10.1001\/jamanetworkopen.2026.7232","article-title":"Machine Learning Model to Predict Postmastectomy Breast Reconstruction Complications","volume":"9","author":"Shaheen","year":"2026","journal-title":"JAMA Netw. Open"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1007\/s00266-023-03430-y","article-title":"Meta-Analysis of Immediate Implant-Based Breast Reconstruction Versus Autologous Breast Reconstruction in the Setting of PMRT","volume":"48","author":"Ren","year":"2024","journal-title":"Aesthet. Plast. Surg."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"e742","DOI":"10.1016\/S1470-2045(17)30617-4","article-title":"Radiotherapy in the setting of breast reconstruction: Types, techniques, and timing","volume":"18","author":"Ho","year":"2017","journal-title":"Lancet Oncol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/jnci\/djx148","article-title":"Impact of Radiotherapy on Complications and Patient-Reported Outcomes After Breast Reconstruction","volume":"110","author":"Jagsi","year":"2018","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Lohasammakul, S., D\u2019John, J., Qasawa, R., Llewellyn, K.J.D., Moltaji, S.M., Fuse, Y., and Chaiyasate, K.M. (2026). 10-Year Experience of Hybrid DIEP with Implant Breast Reconstruction: Univariate Analyses of Risk Factors Associated with Flap Failure. Plast. Reconstr. Surg.","DOI":"10.1097\/PRS.0000000000013029"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1097\/SAP.0000000000002085","article-title":"A Critical Analysis of Prosthetic Augmentation of Autologous Microvascular Breast Reconstruction","volume":"84","author":"Piper","year":"2020","journal-title":"Ann. Plast. Surg."},{"key":"ref_129","doi-asserted-by":"crossref","unstructured":"Muntean, M.V., Pop, I.C., Ilies, R.A., Pelleter, A., Vlad, I.C., and Achimas-Cadariu, P. (2025). Exploring the Role of Autologous Fat Grafting in Implant-Based Breast Reconstruction: A Systematic Review of Complications and Aesthetic Results. J. Clin. Med., 14.","DOI":"10.3390\/jcm14124073"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/18\/7334\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:36:59Z","timestamp":1790077019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/18\/7334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,21]]},"references-count":129,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["jcm15187334"],"URL":"https:\/\/doi.org\/10.3390\/jcm15187334","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,21]]}}}