{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:00:55Z","timestamp":1790870455659,"version":"4.1.0"},"reference-count":142,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015550","name":"Italian Ministry of Health","doi-asserted-by":"publisher","award":["RF-2021-12375208"],"award-info":[{"award-number":["RF-2021-12375208"]}],"id":[{"id":"10.13039\/501100015550","id-type":"DOI","asserted-by":"publisher"}]},{"award":["RF-2021-12375208"],"award-info":[{"award-number":["RF-2021-12375208"]}],"id":[{"id":"https:\/\/ror.org\/00789fa95","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Cardiac computed tomography (CCT) has emerged as a central imaging modality in the workflow for left atrial appendage occlusion (LAAO), as accurate anatomical assessment is vital for successful intervention. CCT provides superior three-dimensional (3D) anatomical detail and isotropic spatial resolution compared to traditional trans-esophageal echocardiography, enabling precise pre-procedural planning, device sizing, and identification of optimal fluoroscopic projections. Furthermore, CCT serves as a highly accurate, non-invasive tool for detecting post-procedural complications such as peri-device leaks and device-related thrombosis. Beyond conventional imaging, CCT-derived datasets now facilitate advanced computational applications, including patient-specific 3D printing, computational fluid dynamics, and finite element modeling, to predict device-tissue interactions and post-implant hemodynamics. Additionally, artificial intelligence is increasingly integrated to automate segmentation and enhance risk stratification. This review provides a comprehensive overview of the expanding role of CCT in LAAO, highlighting its contribution to procedural optimization and the transition toward personalized, engineering-driven cardiac interventions.<\/jats:p>","DOI":"10.3390\/jcm15197361","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:14:39Z","timestamp":1790151279000},"page":"7361","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiac CT Roadmap for Left Atrial Appendage Occlusion: From Planning to Strategy to Follow-Up"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2284-8585","authenticated-orcid":false,"given":"Antonella","family":"Meloni","sequence":"first","affiliation":[{"name":"Bioengineering Unit, Fondazione Monasterio, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Capellini","sequence":"additional","affiliation":[{"name":"BioCardioLab, Bioengineering Unit, Fondazione Monasterio, 54100 Massa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8946-1983","authenticated-orcid":false,"given":"Benigno Marco","family":"Fanni","sequence":"additional","affiliation":[{"name":"BioCardioLab, Bioengineering Unit, Fondazione Monasterio, 54100 Massa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0122-5175","authenticated-orcid":false,"given":"Emanuele","family":"Gasparotti","sequence":"additional","affiliation":[{"name":"BioCardioLab, Bioengineering Unit, Fondazione Monasterio, 54100 Massa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana","family":"Buongiorno","sequence":"additional","affiliation":[{"name":"BioCardioLab, Bioengineering 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