{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:10:18Z","timestamp":1790154618078,"version":"4.0.1"},"reference-count":37,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015696","name":"National Health Insurance Service Ilsan Hospital","doi-asserted-by":"publisher","award":["NHIMC-2026-CR-004"],"award-info":[{"award-number":["NHIMC-2026-CR-004"]}],"id":[{"id":"10.13039\/501100015696","id-type":"DOI","asserted-by":"publisher"}]},{"award":["NHIMC-2026-CR-004"],"award-info":[{"award-number":["NHIMC-2026-CR-004"]}],"id":[{"id":"https:\/\/ror.org\/03c8k9q07","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: Gastric endoscopic submucosal dissection (ESD) is an established organ-preserving treatment for gastric neoplasia, but the short-term safety of ESD in patients aged 80 years or older remains clinically important. We evaluated the efficacy and short-term safety of gastric ESD in patients aged \u226580 years treated under a standardized inpatient post-procedural surveillance pathway. Methods: This retrospective cohort study included 2021 consecutive unique patients who underwent gastric ESD for gastric adenoma or gastric cancer at a single institution between April 2013 and March 2026. Patients were classified as &lt;80 years or \u226580 years. Standard hospitalization was 3 nights\/4 days for patients not receiving antithrombotic agents and 5 nights\/6 days for those receiving antithrombotic agents. The primary safety outcomes were post-ESD bleeding, perforation, pneumonia, and delirium. Absolute risk differences with 95% confidence intervals (CIs) were calculated, and multivariable logistic regression was performed to evaluate the association between age \u2265 80 years and selected efficacy and safety outcomes. Results: Among the 2021 patients, 285 were aged \u226580 years and 1736 were aged &lt;80 years. Non-curative resection was more frequent in patients aged \u226580 years (7.7% vs. 4.6%; p = 0.026), but this difference was not significant after lesion-adjusted analysis. Post-ESD bleeding (2.5% vs. 2.4%), perforation (0.4% vs. 0.7%), and pneumonia (0% vs. 0.1%) were comparable between groups, while delirium occurred in one patient aged \u226580 years. No 30-day mortality occurred in either group. In multivariable analysis, age \u2265 80 years was not independently associated with post-ESD bleeding or perforation, and the primary safety findings were similar after propensity-score matching. Conclusions: In this single-center cohort, gastric ESD in selected patients aged \u226580 years was not independently associated with non-curative resection or increased short-term adverse outcomes. Chronological age alone should not preclude gastric ESD when standardized monitoring and individualized risk assessment are applied.<\/jats:p>","DOI":"10.3390\/jcm15197373","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:14:39Z","timestamp":1790151279000},"page":"7373","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Short-Term Safety of Gastric Endoscopic Submucosal Dissection in Patients Aged 80 Years or Older Under a Standardized Inpatient Post-Procedural Surveillance Pathway: Data from a 13-Year Real-World Cohort Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6561-6752","authenticated-orcid":false,"given":"Youn I","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, 100 Ilsan-ro, Ilsandong-gu, Goyang 10444, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"software","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"visualization","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"}]},{"given":"Sun Young","family":"Won","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, 100 Ilsan-ro, Ilsandong-gu, Goyang 10444, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]},{"given":"Yong Suk","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, 100 Ilsan-ro, Ilsandong-gu, Goyang 10444, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6801-3831","authenticated-orcid":false,"given":"Byung Kyu","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, 100 Ilsan-ro, Ilsandong-gu, Goyang 10444, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"supervision","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Chan Su","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, 100 Ilsan-ro, Ilsandong-gu, Goyang 10444, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Jong Won","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, 100 Ilsan-ro, Ilsandong-gu, Goyang 10444, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8492-2883","authenticated-orcid":false,"given":"Chun Kyon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, 100 Ilsan-ro, Ilsandong-gu, Goyang 10444, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"ref_1","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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