{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:11:48Z","timestamp":1790154708675,"version":"4.0.1"},"reference-count":22,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background: Sensory disturbances of the inferior alveolar nerve (IAN) may follow dental and maxillofacial procedures and impair oral function and quality of life. This scoping review mapped randomized evidence on vitamin-based treatment of established IAN sensory disturbances. Methods: The review protocol was developed prospectively and registered on the Open Science Framework (OSF; osf.io\/bvd54). PubMed, CENTRAL, BASE, SciELO, Europe PMC, and the Virtual Health Library (BVS) Regional Portal were searched from inception, with searches conducted between 31 August and 19 September 2026; the LILACS collection was also searched separately within BVS. Eligible studies compared a vitamin-based intervention with placebo, no vitamin supplementation, or the same standard care without another active treatment. Results: Three randomized studies involving 164 analyzed participants were included. They evaluated heterogeneous B-complex regimens after implant placement, bilateral sagittal split osteotomy, or mandibular third-molar extraction. One study found no significant between-group differences in paresthesia or pain. Another reported greater improvement in sensory-disturbance-related quality of life at 3 and 6 months in a 19-participant subset. The third reported more frequent regression of sensory disturbances in the vitamin group, although no between-group significance test was provided for this comparison and key p values represented within-group changes. Adverse events were not systematically reported. Conclusions: The evidence is sparse and methodologically heterogeneous and does not support firm conclusions regarding clinical effectiveness. Better reported randomized trials using standardized sensory outcomes and explicit safety monitoring are needed.<\/jats:p>","DOI":"10.3390\/jcm15197375","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:14:39Z","timestamp":1790151279000},"page":"7375","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vitamins in the Management of Inferior Alveolar Nerve Sensory Disturbances: A Scoping Review of Randomized Studies"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5580-8941","authenticated-orcid":false,"given":"Wojciech","family":"Macek","sequence":"first","affiliation":[{"name":"Department of Oral Surgery, Preventive Medicine Center, Komorowskiego 12, 30-106 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6199-4753","authenticated-orcid":false,"given":"Maciej","family":"Ch\u0119ci\u0144ski","sequence":"additional","affiliation":[{"name":"National Medical Institute of the Ministry of the Interior and Administration, Wo\u0142oska 137, 02-507 Warsaw, Poland"},{"name":"Department of Maxillofacial Surgery, Hospital of the Ministry of the Interior and Administration, Wojska Polskiego 51, 25-375 Kielce, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamila","family":"Ch\u0119ci\u0144ska","sequence":"additional","affiliation":[{"name":"National Medical Institute of the Ministry of the Interior and Administration, Wo\u0142oska 137, 02-507 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6747-1336","authenticated-orcid":false,"given":"Maja","family":"Kosi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery, Preventive Medicine Center, Komorowskiego 12, 30-106 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6648-2469","authenticated-orcid":false,"given":"Zuzanna","family":"Olejarczyk","sequence":"additional","affiliation":[{"name":"Independent Researcher, 30-381 Cracow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3348-1950","authenticated-orcid":false,"given":"Maciej","family":"Sikora","sequence":"additional","affiliation":[{"name":"National Medical Institute of the Ministry of the Interior and Administration, Wo\u0142oska 137, 02-507 Warsaw, Poland"},{"name":"Department of Maxillofacial Surgery, Hospital of the Ministry of the Interior and Administration, Wojska Polskiego 51, 25-375 Kielce, Poland"},{"name":"Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powsta\u0144c\u00f3w Wielkopolskich 72, 70-111 Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.5037\/jomr.2014.5401","article-title":"Inferior alveolar nerve injury after mandibular third molar extraction: A literature review","volume":"5","author":"Sarikov","year":"2014","journal-title":"J. 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