{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:08:15Z","timestamp":1790168895497,"version":"4.1.0"},"reference-count":19,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: Advanced acquired or congenital temporomandibular joint (TMJ) pathology may severely impair oral function and quality of life, often requiring total joint replacement when conservative and reconstructive treatments fail. Custom-made TMJ prostheses (CMTMJP) have been developed to improve anatomical adaptation and functional outcomes. The aim of this study was to evaluate the medium- to long-term clinical outcomes of CMTMJP from Avinent\u00ae in patients with advanced TMJ pathology requiring TMJ replacement. Methods: An observational follow-up study was conducted in patients treated with CMTMJP at the Department of Oral and Maxillofacial Surgery of Hospital Cl\u00ednic and Barnacl\u00ednic (Barcelona, Spain). Clinical outcomes, including pain intensity assessed using a numerical rating scale, maximum interincisal opening (mm), and occlusal stability, were evaluated before and after surgery. Patients were followed for 50\u201370 months after implantation. Results: Functional improvement was maintained over time, with satisfactory pain control, stable occlusion, and adequate mandibular mobility. No CMTMJP failures, complications, or adverse events related to the prostheses were recorded. Surgeons reported favorable outcomes regarding the planning protocol, surgical placement, and postoperative management of the CMTMJP. Conclusions: CMTMJP replacement appears to be a predictable and reliable treatment option when the TMJ needs to be replaced for any cause, such as degenerative, acquired or congenital condition. The CMTMJP described in this series demonstrated good functional performance and long-term stability, with no major complications observed during 50\u201370 months of follow-up.<\/jats:p>","DOI":"10.3390\/jcm15197395","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:36:07Z","timestamp":1790166967000},"page":"7395","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Custom-Made Total Temporomandibular Joint Replacement: A Long-Term Observational Case Series of Four Patients"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6522-5679","authenticated-orcid":false,"given":"Ram\u00f3n","family":"Sieira-Gil","sequence":"first","affiliation":[{"name":"Oral & Maxillofacial Surgery Department, Hospital Cl\u00ednic de Barcelona, Universitat de Barcelona, 08036 Barcelona, Barcelona, Spain"},{"name":"Facial Plastic & Orthognathic Surgery, SIES Maxillofacial Surgery, Cl\u00ednica Planas, 08034 Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9887-9556","authenticated-orcid":false,"given":"Ada","family":"Ferrer-Fuertes","sequence":"additional","affiliation":[{"name":"Oral & Maxillofacial Surgery Department, Hospital Cl\u00ednic de Barcelona, Universitat de Barcelona, 08036 Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]},{"given":"Eloy","family":"Garc\u00eda-D\u00edez","sequence":"additional","affiliation":[{"name":"Oral & Maxillofacial Surgery Department, Hospital Cl\u00ednic de Barcelona, Universitat de Barcelona, 08036 Barcelona, Barcelona, Spain"},{"name":"Cl\u00ednica Faces, 08021 Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]},{"given":"Francisco","family":"Cuesta-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Oral & Maxillofacial Surgery Department, Hospital Cl\u00ednic de Barcelona, Universitat de Barcelona, 08036 Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9991-2226","authenticated-orcid":false,"given":"Octavi","family":"Camps-Font","sequence":"additional","affiliation":[{"name":"Department of Odontoestomatology, Faculty of Medicine and Health Sciences, Universitat de Barcelona, 08907 L\u2019Hospitalet de Llobregat, Barcelona, Spain"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL), 08907 L\u2019Hospitalet de Llobregat, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"validation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9669-3187","authenticated-orcid":false,"given":"Eduard","family":"Valmaseda-Castell\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Odontoestomatology, Faculty of Medicine and Health Sciences, Universitat de Barcelona, 08907 L\u2019Hospitalet de Llobregat, Barcelona, Spain"},{"name":"Bellvitge Biomedical Research Institute (IDIBELL), 08907 L\u2019Hospitalet de Llobregat, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Carles","family":"Mart\u00ed-Pag\u00e8s","sequence":"additional","affiliation":[{"name":"Oral & Maxillofacial Surgery Department, Hospital Cl\u00ednic de Barcelona, Universitat de Barcelona, 08036 Barcelona, Barcelona, Spain"},{"name":"Cl\u00ednica Faces, 08021 Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"resources","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e393","DOI":"10.11607\/jomi.te20","article-title":"Temporomandibular disorders: A review of etiology, clinical management, and tissue engineering strategies","volume":"28","author":"Murphy","year":"2013","journal-title":"Int. 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