{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:58:16Z","timestamp":1790618296564,"version":"4.1.0"},"reference-count":36,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: Although minimally invasive laparoscopic donor nephrectomy (LDN) has been established as the standard method for donor nephrectomy for adult recipients in recent years, there might still be a role for conventional open donor nephrectomy (ODN) in pediatric kidney transplantation (KTx). To investigate this, we compared the outcomes of LDN with those of ODN in pediatric patients. Methods: A systematic literature search was conducted in Web of Science and Medline (via PubMed) databases, focusing on intraoperative data in donors and short-term postoperative outcomes in pediatric recipients following ODN and LDN. We used a subgroup analysis to compare these outcomes in recipients aged five years or younger. Results: Fifteen datasets comprising 1926 pediatric kidney transplant recipients (1036 ODN and 890 LDN) were included in the quantitative synthesis. There were no significant differences in operation time, warm ischemia time, or blood loss among donors (p &gt; 0.05). There were also no significant differences in the rates of acute graft rejection, delayed graft function, or one-year graft survival between pediatric recipients undergoing ODN and LDN. In the subgroup analysis, the rates of delayed graft function and acute graft rejection were significantly lower in recipients aged \u22645 years in the ODN group compared with the LDN group (Odds ratio (OR), 0.26; p = 0.041 and OR, 0.29; p = 0.016, respectively). The certainty of evidence was very low across all outcomes according to the GRADE assessment. Conclusions: Our findings suggest that outcomes following ODN and LDN appear broadly comparable in pediatric kidney transplantation. However, as the available comparative evidence is derived primarily from studies conducted during the early adoption era of laparoscopic donor nephrectomy, these findings should be interpreted cautiously and mainly in a historical context. The overall certainty of evidence was rated as very low according to GRADE. Contemporary data from high-volume transplant centers are needed to better define outcomes in very young pediatric recipients.<\/jats:p>","DOI":"10.3390\/jcm15197484","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:50:54Z","timestamp":1790614254000},"page":"7484","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Open Versus Laparoscopic Donor Nephrectomy in Pediatric Kidney Transplantation: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"15","author":[{"given":"Rajan","family":"Nikbakhsh","sequence":"first","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, Heidelberg University, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6016-3886","authenticated-orcid":false,"given":"Sepehr Abbasi","family":"Dezfouli","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, Heidelberg University, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nastaran","family":"Sabetkish","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, Heidelberg University, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadamin","family":"Shahrbaf","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, Heidelberg University, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yalda","family":"Mirzaei","sequence":"additional","affiliation":[{"name":"Institute for Laboratory Animal Science, Unklinik RWTH Aachen, 52074 Aachen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Hifdi","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, Heidelberg University, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadsadegh","family":"Sabagh","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, Heidelberg University, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peri","family":"Husen","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, Heidelberg University, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Lurje","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, Heidelberg University, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4487-3332","authenticated-orcid":false,"given":"Claus Peter","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Paediatrics I, Centre for Pediatric and Adolescent Medicine, Medical Faculty Heidelberg, Heidelberg University, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6598-6910","authenticated-orcid":false,"given":"Burkhard","family":"T\u00f6nshoff","sequence":"additional","affiliation":[{"name":"Department of Pediatrics I, University Children\u2019s Hospital Heidelberg, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianeb","family":"Mehrabi","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, Heidelberg University, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Khajeh","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Transplantation Surgery, Heidelberg University, 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.pcl.2018.09.008","article-title":"Long-Term Outcomes of Kidney Transplantation in Children","volume":"66","author":"Winterberg","year":"2019","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Weeda, V., Koliakos, N., Ca\u00ebs, T., Khelif, A., Mikhalski, D., and Lingier, P. (2026). Challenges and outcomes in pediatric and adult kidney transplantation. Front. Pediatr., 14.","DOI":"10.3389\/fped.2026.1779651"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1600-6143.2004.00661.x","article-title":"Laparoscopic live donor nephrectomy: A risk factor for delayed function and rejection in pediatric kidney recipients? A UNOS analysis","volume":"5","author":"Troppmann","year":"2005","journal-title":"Am. J. Transplant."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jpurol.2018.01.027","article-title":"Vascular thrombosis in pediatric kidney transplantation: Graft survival is possible with adequate management","volume":"14","author":"Gander","year":"2018","journal-title":"J. Pediatr. Urol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e14545","DOI":"10.1111\/petr.14545","article-title":"Intraoperative management of pediatric renal transplant recipients: An opportunity for improvement","volume":"27","author":"Baboolal","year":"2023","journal-title":"Pediatr. Transplant."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e14470","DOI":"10.1111\/petr.14470","article-title":"Pediatric renal transplantation-A UNOS database analysis of donor-recipient size mismatch","volume":"27","author":"Kostakis","year":"2023","journal-title":"Pediatr. Transplant."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/SLA.0b013e318153fd13","article-title":"Laparoscopic versus open live donor nephrectomy in renal transplantation: A meta-analysis","volume":"247","author":"Nanidis","year":"2008","journal-title":"Ann. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s00423-014-1196-4","article-title":"Comparison of the laparoscopic versus open live donor nephrectomy: An overview of surgical complications and outcome","volume":"399","author":"Fonouni","year":"2014","journal-title":"Langenbecks Arch. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1089\/end.2006.0208","article-title":"Laparoscopic v open donor nephrectomy for pediatric kidney recipients: Preliminary report of a randomized controlled trial","volume":"21","author":"Basiri","year":"2007","journal-title":"J. Endourol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/ndt\/gfr315","article-title":"Is laparoscopic donation safe for paediatric recipients?\u2013a study of 85 paediatric recipients comparing open and laparoscopic donor nephrectomy","volume":"27","author":"Chandak","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/s41415-022-4359-7","article-title":"PRISMA 2020 updated guideline","volume":"232","author":"Dickson","year":"2022","journal-title":"Br. Dent. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s00423-021-02204-x","article-title":"Systematic reviews in surgery-recommendations from the Study Center of the German Society of Surgery","volume":"406","author":"Kalkum","year":"2021","journal-title":"Langenbecks Arch. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"221.e1","DOI":"10.1016\/j.jpurol.2019.01.007","article-title":"Surgical outcomes after pediatric kidney transplantation at the University of Heidelberg","volume":"15","author":"Mehrabi","year":"2019","journal-title":"J. Pediatr. Urol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"i4919","DOI":"10.1136\/bmj.i4919","article-title":"ROBINS-I: A tool for assessing risk of bias in non-randomised studies of interventions","volume":"355","author":"Sterne","year":"2016","journal-title":"BMJ"},{"key":"ref_15","first-page":"829","article-title":"Assessment of the strength of recommendation and quality of evidence: GRADE checklist. A descriptive study","volume":"140","author":"Bezerra","year":"2022","journal-title":"Sao Paulo Med. J."},{"key":"ref_16","first-page":"417","article-title":"Sensitivity analysis and diagnostics","volume":"Volume 2","author":"Greenhouse","year":"2009","journal-title":"The Handbook of Research Synthesis and Meta-Analysis"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"3097","DOI":"10.1016\/S0041-1345(02)03610-2","article-title":"Outcomes of pediatric living donor renal transplant after laparoscopic versus open donor nephrectomy","volume":"34","author":"Kayler","year":"2002","journal-title":"Transplant. Proc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1046\/j.1600-6143.2003.00216.x","article-title":"Laparoscopic (vs open) live donor nephrectomy: A UNOS database analysis of early graft function and survival","volume":"3","author":"Troppmann","year":"2003","journal-title":"Am. J. Transplant."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.urology.2003.09.043","article-title":"Laparoscopic donor nephrectomy for pediatric recipients: Outcomes analysis","volume":"63","author":"Abrahams","year":"2004","journal-title":"Urology"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1399-3046.2004.00195.x","article-title":"Hand-assisted laparoscopic donor nephrectomy for pediatric kidney allograft recipients","volume":"8","author":"Kim","year":"2004","journal-title":"Pediatr. Transplant."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1111\/j.1600-6143.2005.01061.x","article-title":"Laparoscopic versus open renal procurement for pediatric recipients of living donor renal transplantation","volume":"5","author":"Singer","year":"2005","journal-title":"Am. J. Transplant."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1399-3046.2005.00478.x","article-title":"Impact of laparoscopic donor nephrectomy on allograft function in pediatric renal transplant recipients: A single-center report","volume":"10","author":"Baqi","year":"2006","journal-title":"Pediatr. Transplant."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1399-3046.2006.00664.x","article-title":"Laparoscopic live donor nephrectomy: The pediatric recipient in a dual-site program","volume":"11","author":"Bergman","year":"2007","journal-title":"Pediatr. Transplant."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4103\/0970-1591.51358","article-title":"Evaluating graft function in pediatric recipients for living donor renal transplantation: Is laparoscopic donor nephrectomy safe?","volume":"25","author":"Mishra","year":"2009","journal-title":"Indian J. Urol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1097\/TP.0b013e318211d32a","article-title":"Laparoscopic donor nephrectomy does not compromise outcomes for pediatric transplant recipients","volume":"91","author":"Mamode","year":"2011","journal-title":"Transplantation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/petr.12008","article-title":"Long-term outcomes of living donor kidney transplants in pediatric recipients following laparoscopic vs. open donor nephrectomy","volume":"16","author":"Chaykovska","year":"2012","journal-title":"Pediatr. Transplant."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/petr.12082","article-title":"Comparison of outcomes of hand-assisted laparoscopic to open donor nephrectomy for pediatric recipients","volume":"17","author":"Baron","year":"2013","journal-title":"Pediatr. Transplant."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1159\/000049835","article-title":"Renal transplantation in small children\u2014A comparison between surgical procedures","volume":"40","author":"Adams","year":"2001","journal-title":"Eur. Urol."},{"key":"ref_29","first-page":"e34679","article-title":"United Network for Organ Sharing (UNOS) Database Analysis of Factors Associated with Kidney Transplant Time on Waiting List","volume":"15","author":"Fritz","year":"2023","journal-title":"Cureus"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S0090-4295(02)02122-2","article-title":"Laparoscopic adult donor nephrectomy for pediatric renal transplantation","volume":"61","author":"Hsu","year":"2003","journal-title":"Urology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"iv39","DOI":"10.1093\/ndt\/gfs544","article-title":"Risk factors for graft loss and mortality after renal transplantation according to recipient age: A prospective multicentre study","volume":"27","author":"Morales","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Oweira, H., Ramouz, A., Ghamarnejad, O., Khajeh, E., Ali-Hasan-Al-Saegh, S., Nikbakhsh, R., Rei\u00dffelder, C., Rahbari, N., Mehrabi, A., and Sadeghi, M. (2022). Risk Factors of Rejection in Renal Transplant Recipients: A Narrative Review. J. Clin. Med., 11.","DOI":"10.3390\/jcm11051392"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1007\/s11701-023-01681-0","article-title":"Robot-assisted versus laparoscopic living donor nephrectomy: Superior outcomes after completion of the learning curve","volume":"17","author":"Khajeh","year":"2023","journal-title":"J. Robot. Surg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1399-3046.2007.00796.x","article-title":"Effect of donor pneumoperitoneum on early allograft perfusion following renal transplantation in pediatric patients: An intraoperative Doppler ultrasound study","volume":"12","author":"Dave","year":"2008","journal-title":"Pediatr. Transplant."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/petr.12587","article-title":"Laparoscopic donor nephrectomy for the pediatric recipient population: Risk factors for adverse outcomes","volume":"19","author":"Walther","year":"2015","journal-title":"Pediatr. Transplant."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1016\/j.euf.2022.03.021","article-title":"Surgical Approaches and Outcomes in Living Donor Nephrectomy: A Systematic Review and Meta-analysis","volume":"8","author":"Kristensen","year":"2022","journal-title":"Eur. Urol. Focus"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/19\/7484\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:14:35Z","timestamp":1790615675000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/19\/7484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,26]]},"references-count":36,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["jcm15197484"],"URL":"https:\/\/doi.org\/10.3390\/jcm15197484","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,26]]}}}