{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:58:50Z","timestamp":1790852330070,"version":"4.1.0"},"reference-count":30,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["ORF-RC-2026-25-10"],"award-info":[{"award-number":["ORF-RC-2026-25-10"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]},{"award":["ORF-RC-2026-25-10"],"award-info":[{"award-number":["ORF-RC-2026-25-10"]}],"id":[{"id":"https:\/\/ror.org\/02f81g417","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background and Objectives: Psoriasis is a chronic immune-mediated inflammatory disease whose burden extends beyond the skin. Community-based data from Saudi Arabia are scarce, as most local studies recruit from dermatology clinics and miss people who never reach specialist care. This study examined its frequency in a multi-regional sample of adults in Saudi Arabia, described its clinical profile, identified factors associated with it, and examined its association with quality of life. Methods: An exploratory cross-sectional study recruited 1619 adults residing in Saudi Arabia by online convenience sampling, using a self-administered online questionnaire covering sociodemographic and health characteristics, psoriasis status and clinical features, lifestyle factors, and the Arabic WHOQOL-BREF. Groups were compared using the chi-square, Fisher\u2019s exact and Mann\u2013Whitney U tests. Multivariable logistic regression, with Firth-penalized and parsimonious sensitivity models, examined factors associated with psoriasis, and five linear models were fitted for the overall quality of life facet and each domain. Results: Psoriasis was reported by 3.3% of participants (95% CI 2.5 to 4.3), and by 2.7% (95% CI 2.0 to 3.6) when restricted to physician-diagnosed cases. Onset occurred before age 35 in 84.6% of cases, psychological stress was the commonest trigger (69.2%), and herbal remedies had been used more often (34.6%) than oral systemic agents (25.0%), phototherapy (15.4%) or biologics (7.7%). Current smoking was associated with higher odds of reporting psoriasis (aOR 4.23, 95% CI 1.97 to 9.08, p &lt; 0.001) and male sex with lower odds (aOR 0.41, 95% CI 0.19 to 0.90), and this was consistent across sensitivity models; middle income and university education were also associated with higher odds, although these may reflect differences in who receives a diagnosis rather than differences in risk. Psoriasis was independently associated with a lower overall quality of life and general health score (\u03b2 = \u22126.73, 95% CI \u221212.75 to \u22120.71, p = 0.028); all four domain coefficients were negative but non-significant. Conclusions: Psoriasis was reported by roughly one in thirty participants and was associated with poorer self-rated quality of life. Smoking was the most consistent modifiable correlate, and treatment patterns suggest reliance on remedies outside established care.<\/jats:p>","DOI":"10.3390\/jcm15197622","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:25:44Z","timestamp":1790850344000},"page":"7622","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associated Factors and Quality of Life in Self-Reported Psoriasis Among Adults in Saudi Arabia: An Exploratory Cross-Sectional Study"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4954-0742","authenticated-orcid":false,"given":"Rena H.","family":"Alharbi","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4525-1191","authenticated-orcid":false,"given":"Mohammad A.","family":"Jareebi","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, College of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khlood K.","family":"Alattas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shatha H.","family":"Moharaq","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alia A.","family":"Alruwished","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4442-8834","authenticated-orcid":false,"given":"Ghufran A.","family":"Almowalad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah H.","family":"Bahakeem","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal A.","family":"Badri","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saja A.","family":"Almraysi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9346-6680","authenticated-orcid":false,"given":"Rauf M.","family":"Mawkili","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuha H.","family":"Abutalib","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, College of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amany","family":"Mashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Armed Forces Hospital, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6552-6260","authenticated-orcid":false,"given":"Farjah H.","family":"Algahtani","sequence":"additional","affiliation":[{"name":"Oncology Center, Epidemiology and Public Health Research, Faculty of Medicine, King Saud University\/King Saud Medical City, Riyadh 12373, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0841-6724","authenticated-orcid":false,"given":"Abdulwahab A.","family":"Aqeeli","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, College of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa H.","family":"Hakami","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1001\/jama.2020.4006","article-title":"Pathophysiology, clinical presentation, and treatment of psoriasis: A review","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"m1590","DOI":"10.1136\/bmj.m1590","article-title":"National, regional, and worldwide epidemiology of psoriasis: Systematic analysis and modelling study","volume":"369","author":"Parisi","year":"2020","journal-title":"BMJ"},{"key":"ref_4","unstructured":"World Health Organization (2016). 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Dermatol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/19\/7622\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:38:01Z","timestamp":1790851081000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/19\/7622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":30,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["jcm15197622"],"URL":"https:\/\/doi.org\/10.3390\/jcm15197622","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]}}}