{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:56:56Z","timestamp":1790935016711,"version":"4.1.0"},"reference-count":8,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Italian Ministry of Health\u2019s \u2018Ricerca Corrente\u2019"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Pulmonary sequestration is a rare congenital malformation supplied by an aberrant systemic artery, making parenchyma-sparing resection technically challenging because safe vascular control and accurate identification of the resection plane are both required. Indocyanine green (ICG) fluorescence has been used to delineate the perfusion boundary between sequestrated and normal lung, whereas preoperative embolization has traditionally been performed to reduce the risk of intraoperative bleeding. We describe a staged approach in which selective coil embolization of the aberrant feeding artery, performed one day before surgery, was followed by video-assisted fluorescence-guided wedge resection. Preoperative embolization established devascularization before surgery, while subsequent ICG fluorescence provided clear real-time delineation of the perfusion boundary, enabling tailored parenchyma-sparing resection. Although this observation derives from a single case and does not support routine preoperative embolization, it raises the hypothesis that the interval between embolization and surgery may influence the physiological conditions under which subsequent fluorescence-guided perfusion assessment is performed. This potential effect requires confirmation through quantitative fluorescence assessment and comparative studies.<\/jats:p>","DOI":"10.3390\/jcm15197635","type":"journal-article","created":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:10:48Z","timestamp":1790932248000},"page":"7635","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Staged Preoperative Embolization Followed by ICG-Guided Parenchyma-Sparing Resection of Pulmonary Sequestration: A Case Report"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8394-2719","authenticated-orcid":false,"given":"Giuseppe","family":"Mangiameli","sequence":"first","affiliation":[{"name":"Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0860-1647","authenticated-orcid":false,"given":"Debora","family":"Brascia","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4167-1295","authenticated-orcid":false,"given":"Giuseppe","family":"Ferrillo","sequence":"additional","affiliation":[{"name":"Department of Radiology, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Marulli","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, IRCCS Humanitas Research Hospital, Via Manzoni 56, Rozzano, 20089 Milan, Italy"},{"name":"Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s40792-021-01277-6","article-title":"Lessons learned from hybrid surgery with preoperative coil embolization for an aberrant artery in pulmonary sequestration","volume":"7","author":"Nakanishi","year":"2021","journal-title":"Surg. Case Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13019-018-0733-6","article-title":"Hybrid surgery in treatment of pulmonary sequestration with abdominal aorta feeding vessel: A case report","volume":"13","author":"Zhou","year":"2018","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1053\/j.semtcvs.2017.05.015","article-title":"Surgery for Intralobar Pulmonary Sequestration Using Indocyanine Green Fluorescence Navigation: A Case Report","volume":"30","author":"Yamanashi","year":"2018","journal-title":"Semin. Thorac. Cardiovasc. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s13256-019-2128-2","article-title":"Indocyanine green fluorescence-guided thoracoscopic pulmonary resection for intralobar pulmonary sequestration: A case report","volume":"13","author":"Motono","year":"2019","journal-title":"J. Med. Case Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s11748-020-01459-3","article-title":"Intraoperative real-time hemodynamics in intralobar pulmonary sequestration using indocyanine green and near-infrared thoracoscopy","volume":"69","author":"Motohashi","year":"2021","journal-title":"Gen. Thorac. Cardiovasc. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"5714","DOI":"10.21037\/jtd-23-892","article-title":"Complete visualization using indocyanine green in thoracic surgery for pulmonary sequestration","volume":"15","author":"Nakanishi","year":"2023","journal-title":"J. Thorac. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40792-023-01600-3","article-title":"Combined basilar subsegmentectomy for intralobar sequestration via uniportal VATS: A case report","volume":"9","author":"Takamori","year":"2023","journal-title":"Surg. Case Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.xjtc.2021.04.035","article-title":"Robotic left ventral segmentectomy","volume":"8","author":"Mangiameli","year":"2021","journal-title":"JTCVS Tech."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/19\/7635\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T09:21:06Z","timestamp":1790932866000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/19\/7635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,2]]},"references-count":8,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["jcm15197635"],"URL":"https:\/\/doi.org\/10.3390\/jcm15197635","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,2]]}}}