{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:52:08Z","timestamp":1791276728383,"version":"4.1.0"},"reference-count":23,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Myoepithelial carcinoma is a rare malignant salivary gland tumor that is particularly uncommon in pediatric patients. A 14-year-old girl presented with a painless, slowly enlarging hard palate mass that had been present for 2 years. Clinically, the lesion closely resembled a benign tumor due to its young presentation age, well-encapsulated state, absence of mucosal ulceration, and lack of lymphadenopathy, leading to an initial diagnosis of pleomorphic adenoma. Complete surgical excision with superficial mucosa preservation was initially performed. However, histopathological examination revealed myoepithelial carcinoma with infiltrative growth despite its well-circumscribed appearance. Consequently, a second-stage wide local excision was performed to achieve adequate safety margins. The patient recovered uneventfully without functional impairment, with preservation of oral mucosal mobility. No evidence of recurrence was observed during 18 months of follow-up. This case demonstrates that myoepithelial carcinoma may present as a clinically benign, well-circumscribed palatal mass even in pediatric patients, emphasizing that benign clinical features and a negative intraoperative frozen-section result do not exclude malignancy and highlighting the importance of careful permanent histopathological examination and long-term postoperative surveillance.<\/jats:p>","DOI":"10.3390\/jcm15197708","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:06:47Z","timestamp":1791274007000},"page":"7708","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of Benign-Appearing Myoepithelial Carcinoma of the Hard Palate in an Adolescent"],"prefix":"10.3390","volume":"15","author":[{"given":"Eun Young","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, College of Medicine and Medial Research Institute, Chungbuk National University, Cheongju 28644, Republic of Korea"},{"name":"Department of Oral and Maxillofacial Surgery, Chungbuk National University Hospital, Cheongju 28644, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9198-321X","authenticated-orcid":false,"given":"Baljinnyam","family":"Altangerel","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, College of Medicine and Medial Research Institute, Chungbuk National University, Cheongju 28644, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8927-059X","authenticated-orcid":false,"given":"Kang Hee","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, College of Medicine and Medial Research Institute, Chungbuk National University, Cheongju 28644, Republic of Korea"},{"name":"Department of Oral and Maxillofacial Surgery, Chungbuk National University Hospital, Cheongju 28644, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.path.2020.09.008","article-title":"Myoepithelial Carcinoma","volume":"14","author":"Xu","year":"2021","journal-title":"Surg. Pathol. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/jop.13395","article-title":"Clinicopathological and survival profile of patients with salivary gland myoepithelial carcinoma: A systematic review","volume":"52","author":"Lavareze","year":"2023","journal-title":"J. Oral Pathol. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.anl.2005.04.001","article-title":"Malignant myoepithelioma arising from recurrent pleomorphic adenoma of the soft palate","volume":"32","author":"Karatzanis","year":"2005","journal-title":"Auris Nasus Larynx"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1097\/00000478-200006000-00001","article-title":"Myoepithelial carcinoma of the salivary glands: A clinicopathologic study of 25 patients","volume":"24","author":"Savera","year":"2000","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1001\/archoto.2010.104","article-title":"Myoepithelial Carcinoma of the Salivary Glands: A Clinicopathologic Study of 51 Cases in a Tertiary Cancer Center","volume":"136","author":"Kane","year":"2010","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"50","DOI":"10.33545\/26646455.2025.v7.i2a.69","article-title":"Salivary Gland Tumours in Children and Adolescents: A 60 Case Study","volume":"7","author":"Bashar","year":"2025","journal-title":"Int. J. Otolaryngol. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"42","DOI":"10.58614\/jahsm5127","article-title":"Childhood Conundrum: A Rare Encounter with Myoepithelial Carcinoma of the Parotid Gland in an 8-Year-Old Girl","volume":"5","author":"Prathibha","year":"2025","journal-title":"J. Appl. Health Sci. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12105-022-01502-0","article-title":"Top Ten Differentials to Mull Over for Head and Neck Myoepithelial Neoplasms","volume":"17","author":"Thompson","year":"2023","journal-title":"Head Neck Pathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s12105-021-01346-0","article-title":"Myoepithelial Carcinoma Ex-Pleomorphic Adenoma: A Rare Pathology Misdiagnosed as Pleomorphic Adenoma; With a Novel TERT Promoter Mutation and High PD-L1 Expression","volume":"16","author":"Cormier","year":"2022","journal-title":"Head Neck Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.joms.2015.03.054","article-title":"Myoepithelial Carcinoma of the Salivary Glands: A Clinicopathologic Study of 29 Patients","volume":"73","author":"Wang","year":"2015","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.4103\/0976-237X.132372","article-title":"Myoepithelial carcinoma of buccal mucosa: A rare tumor","volume":"5","author":"Lata","year":"2014","journal-title":"Contemp. Clin. Dent."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/cncr.10314","article-title":"Cytology of myoepithelial carcinoma of the salivary gland","volume":"96","author":"Chhieng","year":"2002","journal-title":"Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S0165-5876(03)00062-4","article-title":"Massive infra-clinic invasion of the facial nerve by a myoepithelial carcinoma of the parotid","volume":"67","author":"Robier","year":"2003","journal-title":"Int. J. Pediatr. Otorhinolaryngol."},{"key":"ref_14","first-page":"620","article-title":"Malignant myoepithelioma of the hard palate: 9-year follow-up","volume":"75","author":"Patrocinio","year":"2009","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"848","DOI":"10.3349\/ymj.2009.50.6.848","article-title":"Malignant myoepithelioma of the palate: A case report with review of the clinicopathological characteristics","volume":"50","author":"Acikalin","year":"2009","journal-title":"Yonsei Med. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"370","DOI":"10.4103\/0976-237X.103641","article-title":"Malignant myoepithelioma of palate","volume":"3","author":"Richa","year":"2012","journal-title":"Contemp. Clin. Dent."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"154","DOI":"10.5794\/jjoms.61.154","article-title":"A case of myoepithelial carcinoma in the palate derived from myoepithelioma","volume":"61","author":"Koike","year":"2015","journal-title":"Jpn. J. Oral Maxillofac. Surg."},{"key":"ref_18","first-page":"3863270","article-title":"Clear Cell Myoepithelial Carcinoma Arising from the Hard Palate with Metastasis to the Lungs","volume":"2019","author":"Fang","year":"2019","journal-title":"Case Rep. Pathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/ajcp\/68.2.213","article-title":"Intranasal Mixed Tumors (Pleomorphic Adenomas): A Clinicopathologic Study of 40 Cases","volume":"68","author":"Compagno","year":"1977","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/PAS.0000000000000933","article-title":"Epithelial-Myoepithelial Carcinoma: Frequent Morphologic and Molecular Evidence of Preexisting Pleomorphic Adenoma, Common: HRAS: Mutations in: PLAG1-: Intact and: HMGA2-: Intact Cases, and Occasional: TP53, FBXW7, and: SMARCB1: Alterations in High-grade Cases","volume":"42","author":"Udager","year":"2018","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s12105-009-0102-9","article-title":"An update on grading of salivary gland carcinomas","volume":"3","author":"Seethala","year":"2009","journal-title":"Head Neck Pathol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.anl.2012.03.002","article-title":"Malignant myoepithelioma of the soft palate","volume":"40","year":"2013","journal-title":"Auris Nasus Larynx"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3892\/ol.2025.15007","article-title":"Myoepithelial carcinoma of submaxillary gland: A case report","volume":"29","author":"Li","year":"2025","journal-title":"Oncol. Lett."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/19\/7708\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:16:12Z","timestamp":1791274572000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/15\/19\/7708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,6]]},"references-count":23,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2026,10]]}},"alternative-id":["jcm15197708"],"URL":"https:\/\/doi.org\/10.3390\/jcm15197708","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,6]]}}}