{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:55:16Z","timestamp":1791363316390,"version":"4.3.1"},"reference-count":40,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background and Objectives: The objective was to evaluate the association between serum 25-hydroxyvitamin D [25(OH)D] measured before functional loading and long-term peri-implant marginal bone loss (MBL). Materials and Methods: This retrospective study included 60 systemically healthy patients with 136 implants. Patients were classified as vitamin D-deficient (&lt;20 ng\/mL; n = 30) or -sufficient (\u226520 ng\/mL; n = 30). MBL was calculated from periapical radiographs obtained at prosthetic delivery and final follow-up (mean, 39.46 months; range, 34\u201348 months). Clinical parameters and implant loss were secondary outcomes. Between-group comparisons used the Mann\u2013Whitney U and Fisher\u2019s exact tests; associations were examined using Spearman\u2019s rank correlation. Results: MBL was greater in the deficient group than in the sufficient group (0.98 \u00b1 0.25 mm vs. 0.42 \u00b1 0.32 mm; p &lt; 0.001). Serum 25(OH)D was inversely correlated with MBL in the deficient group (rs = \u22120.720), sufficient group (rs = \u22120.604), and overall sample (rs = \u22120.862; all p &lt; 0.001). No statistically significant between-group differences were detected in the clinical parameters (all p &gt; 0.05). Conclusions: Lower baseline serum 25(OH)D was associated with greater long-term MBL, while clinical parameters and patient-level implant loss did not differ between groups.<\/jats:p>","DOI":"10.3390\/jcm15197719","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:28:57Z","timestamp":1791361737000},"page":"7719","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Serum 25-Hydroxyvitamin D Status and Long-Term Marginal Bone Loss Around Dental Implants"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-1032-3709","authenticated-orcid":false,"given":"Okan","family":"\u00d6zen","sequence":"first","affiliation":[{"name":"Department of Periodontolgy, Faculty of Dentistry, Inonu University, 44280 Malatya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5183-6295","authenticated-orcid":false,"given":"Vesile Elif","family":"Toy","sequence":"additional","affiliation":[{"name":"Department of Periodontolgy, Faculty of Dentistry, Inonu University, 44280 Malatya, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"writing-review-editing","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"methodology","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"conceptualization","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Manfredini, M., Pellegrini, M., Rigoni, M., Veronesi, V., Beretta, M., Maiorana, C., and Poli, P.P. 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