{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:07:47Z","timestamp":1792789667144,"version":"4.5.0"},"reference-count":39,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Patient-Centered Clinical Research Coordinating Center","award":["RS-2025-02217932"],"award-info":[{"award-number":["RS-2025-02217932"]}],"id":[{"id":"https:\/\/ror.org\/00fzvsb30","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Clin. Med.","JCM"],"abstract":"<jats:p>Background\/Objectives: To describe the study protocol and baseline characteristics of participants in the Myopic Normal-Tension Glaucoma Treatment Study (MYNT-GTS), which is a randomized controlled trial evaluating the effect of intraocular pressure (IOP)-lowering treatment on glaucoma progression in eyes with myopic normal-tension glaucoma (NTG). Methods: A prospective, multicenter, randomized controlled clinical trial and baseline cross-sectional analysis. The study enrolled 473 treatment-na\u00efve NTG eyes with myopia (spherical equivalent \u2264 \u22121.0 diopters or axial length [AXL] &gt; 24.0 mm) aged 20\u201360 years from 9 tertiary referral centers in South Korea. Participants were randomized at a 1:1 ratio into a treated group and an untreated group managed by active surveillance, and stratified by age, baseline IOP, AXL, and visual field (VF) mean deviation (MD). Treatment was initiated or intensified when predefined structural or functional progression was detected. Comprehensive examinations including quantitative assessments of the optic nerve head structure and microvasculature, medication adherence, and quality of life were performed every 4 months during the first year and every 6 months thereafter. Glaucoma progression was assessed from the rate of circumpapillary retinal nerve fiber layer (RNFL) thinning, and the rate of VF deterioration was assessed from the MD or visual field index (VFI). Results: The 473 enrolled participants comprised 239 assigned to the treated group and 234 to the untreated group. Most of the baseline variables did not differ significantly between the groups, including age (43.1 \u00b1 9.1 vs. 43.9 \u00b1 9.1 years [mean \u00b1 standard deviation], p = 0.33), baseline IOP (14.9 \u00b1 2.6 vs. 14.7 \u00b1 2.5 mmHg, p = 0.26), AXL (26.31 \u00b1 1.37 vs. 26.32 \u00b1 1.34 mm, p = 0.94), global RNFL thickness (79.5 \u00b1 11.4 vs. 80.5 \u00b1 13.2 \u03bcm, p = 0.38), and VF MD (\u22122.71 \u00b1 2.58 vs. \u22122.32 \u00b1 2.52 dB, p = 0.10). Conclusions: The vast majority of the analyzed variables did not differ significantly between the treated and untreated groups at baseline, supporting the validity of the subsequent comparisons. As the first prospective, multicenter randomized controlled trial dedicated to myopic NTG, the MYNT-GTS should clarify the efficacy of IOP-lowering treatment and inform the individualized management of myopic NTG. Trial Registration: Clinical Research Information Service (CRIS), Republic of Korea, KCT0005225.<\/jats:p>","DOI":"10.3390\/jcm15197734","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T01:40:17Z","timestamp":1791596417000},"page":"7734","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Myopic Normal Tension Glaucoma Treatment Study (MYNT-GTS): Protocol and Baseline Characteristics of a Randomized Controlled Trial"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9393-9452","authenticated-orcid":false,"given":"Eun Ji","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Republic of 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Jiwoong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Pusan National University College of Medicine, Pusan National University Hospital, Busan 49241, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0313-3928","authenticated-orcid":false,"given":"Sangwoo","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Pusan National University College of Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Sang Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chonnam National University Hospital, Gwangju 61469, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7512-7303","authenticated-orcid":false,"given":"Mi Sun","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chonnam National University Hospital, Gwangju 61469, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Ji-Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Ewha Womans University College of Medicine, Ewha Womans University Seoul Hospital, Seoul 07804, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Gyu-Nam","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Institute of Health Sciences, Gyeongsang National University School of Medicine, Gyeongsang National University Hospital, Jinju 52727, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Jong Chul","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Ji Eun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kangwon National University School of Medicine, Chuncheon 24341, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4692-3164","authenticated-orcid":false,"given":"Kyoung Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University Boramae Medical Center, Seoul 07061, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"},{"role":"writing-review-editing","vocabulary":"credit"}]},{"given":"Tae-Woo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Republic of 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