{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:32:07Z","timestamp":1760243527770,"version":"build-2065373602"},"reference-count":5,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T00:00:00Z","timestamp":1376870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>FAPA syndrome (periodic fever, aphthous stomatititis, pharyngitis and adenitis) is a relatively new entity described in pediatric patients. In adults, reports of FAPA are limited to rare case reports. The differential diagnosis of FAPA in adults includes Behcet\u2019s syndrome, familial Mediterranean fever (FMF), Hyper IgD syndrome and juvenile rheumatoid arthritis (JRA), i.e., adult Still\u2019s disease. With FAPA syndrome, between episodes patients are completely asymptomatic and serologic inflammatory markers such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and white blood cell (WBC) count are normal. The etiology of FAFA is unknown, but lack of secondary cases or clustering in close contacts, lack of seasonality, and the lack of progression for years argue against an infectious etiology. We describe an extremely rare case of an adult with a recurrent FUO with profuse night sweats and prominent chills due to FAPA syndrome.<\/jats:p>","DOI":"10.3390\/jcm2030045","type":"journal-article","created":{"date-parts":[[2013,8,19]],"date-time":"2013-08-19T12:27:44Z","timestamp":1376915264000},"page":"45-48","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Recurrent Fever of Unknown Origin (FUO) Due to Periodic Fever, Aphthous Stomatititis, Pharyngitis and Adenitis (FAPA) Syndrome in an Adult"],"prefix":"10.3390","volume":"2","author":[{"given":"Sigridh","family":"Mu\u00f1oz-G\u00f3mez","sequence":"first","affiliation":[{"name":"Infectious Disease Division, Winthrop-University Hospital, Mineola, New York, NY 11501, USA"},{"name":"School of Medicine, State University of New York, Stony Brook, New York, NY 11794, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burke","family":"Cunha","sequence":"additional","affiliation":[{"name":"Infectious Disease Division, Winthrop-University Hospital, Mineola, New York, NY 11501, USA"},{"name":"School of Medicine, State University of New York, Stony Brook, New York, NY 11794, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2013,8,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.idc.2007.08.004","article-title":"Recurrent fevers of unknown origin","volume":"21","author":"Knockaert","year":"2007","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.idc.2007.09.004","article-title":"Fever of unknown origin: Focused diagnostic approach based on clinical clues from the history, physical examination and laboratory tests","volume":"21","author":"Cunha","year":"2007","journal-title":"Infect. Dis. Clin. N. Am."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0022-3476(87)80285-8","article-title":"Syndrome of periodic fever, pharyngitis, and aphthous stomatitis","volume":"110","author":"Marshall","year":"1987","journal-title":"J. Pediatr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0022-3476(99)70321-5","article-title":"Periodic fever syndrome in children","volume":"135","author":"Thomas","year":"1999","journal-title":"J. Pediatr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"S212","DOI":"10.1016\/j.jaci.2005.12.838","article-title":"A case of adult-onset pFAPA","volume":"117","author":"Cavuoto","year":"2006","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/2\/3\/45\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:48:44Z","timestamp":1760219324000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/2\/3\/45"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,19]]},"references-count":5,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,9]]}},"alternative-id":["jcm2030045"],"URL":"https:\/\/doi.org\/10.3390\/jcm2030045","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2013,8,19]]}}}