{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:06:42Z","timestamp":1790518002393,"version":"4.1.0"},"reference-count":63,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T00:00:00Z","timestamp":1413504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002803","name":"Fondazione Cariplo","doi-asserted-by":"publisher","award":["SC 2012-0513"],"award-info":[{"award-number":["SC 2012-0513"]}],"id":[{"id":"10.13039\/501100002803","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Motor neuron diseases (MNDs) are neuromuscular disorders affecting rather exclusively upper motor neurons (UMNs) and\/or lower motor neurons (LMNs). The clinical phenotype is characterized by muscular weakness and atrophy leading to paralysis and almost invariably death due to respiratory failure. Adult MNDs include sporadic and familial amyotrophic lateral sclerosis (sALS-fALS), while the most common infantile MND is represented by spinal muscular atrophy (SMA). No effective treatment is ccurrently available for MNDs, as for the vast majority of neurodegenerative disorders, and cures are limited to supportive care and symptom relief. The lack of a deep understanding of MND pathogenesis accounts for the difficulties in finding a cure, together with the scarcity of reliable in vitro models. Recent progresses in stem cell field, in particular in the generation of induced Pluripotent Stem Cells (iPSCs) has made possible for the first time obtaining substantial amounts of human cells to recapitulate in vitro some of the key pathogenetic processes underlying MNDs. In the present review, recently published studies involving the use of iPSCs to unravel aspects of ALS and SMA pathogenesis are discussed with an overview of their implications in the process of finding a cure for these still  orphan disorders.<\/jats:p>","DOI":"10.3390\/jcm3041124","type":"journal-article","created":{"date-parts":[[2014,10,17]],"date-time":"2014-10-17T10:27:19Z","timestamp":1413541639000},"page":"1124-1145","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["iPSC-Based Models to Unravel Key Pathogenetic Processes Underlying Motor Neuron Disease Development"],"prefix":"10.3390","volume":"3","author":[{"given":"Irene","family":"Faravelli","sequence":"first","affiliation":[{"name":"Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, Neurology Unit, IRCCS Foundation Ca'Granda Ospedale Maggiore Policlinico, via Francesco Sforza 35, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Frattini","sequence":"additional","affiliation":[{"name":"Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, Neurology Unit, IRCCS Foundation Ca'Granda Ospedale Maggiore Policlinico, via Francesco Sforza 35, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnese","family":"Ramirez","sequence":"additional","affiliation":[{"name":"Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, Neurology Unit, IRCCS Foundation Ca'Granda Ospedale Maggiore Policlinico, via Francesco Sforza 35, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Stuppia","sequence":"additional","affiliation":[{"name":"Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, Neurology Unit, IRCCS Foundation Ca'Granda Ospedale Maggiore Policlinico, via Francesco Sforza 35, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5447-0882","authenticated-orcid":false,"given":"Monica","family":"Nizzardo","sequence":"additional","affiliation":[{"name":"Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, Neurology Unit, IRCCS Foundation Ca'Granda Ospedale Maggiore Policlinico, via Francesco Sforza 35, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Corti","sequence":"additional","affiliation":[{"name":"Dino Ferrari Centre, Neuroscience Section, Department of Pathophysiology and Transplantation (DEPT), University of Milan, Neurology Unit, IRCCS Foundation Ca'Granda Ospedale Maggiore Policlinico, via Francesco Sforza 35, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1136\/bmj.39493.511759.BE","article-title":"Diagnosis and management of motor neurone disease","volume":"336","author":"McDermott","year":"2008","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.14336\/AD.2013.0400295","article-title":"Amyotrophic lateral sclerosis: An update for 2013 clinical features, pathophysiology, management and therapeutic trials","volume":"4","author":"Gordon","year":"2013","journal-title":"Aging Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1242\/dmm.015719","article-title":"Fishing for causes and cures of motor neuron disorders","volume":"7","author":"Patten","year":"2014","journal-title":"Dis. Model. Mech."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1136\/practneurol-2011-000199","article-title":"Respiratory management of motor neurone disease: A review of current practice and new developments","volume":"12","author":"Rafiq","year":"2012","journal-title":"Pract. Neurol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S0140-6736(10)61156-7","article-title":"Amyotrophic lateral sclerosis","volume":"377","author":"Kiernan","year":"2011","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ejmg.2014.01.002","article-title":"Recent progress in the genetics of motor neuron disease","volume":"57","author":"Finsterer","year":"2014","journal-title":"Eur. J. Med. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/jnnp.2009.183525","article-title":"Incidence of amyotrophic lateral sclerosis in europe","volume":"81","author":"Logroscino","year":"2010","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/17482968.2010.502940","article-title":"The epidemiology and treatment of als: Focus on the heterogeneity of the disease and critical appraisal of therapeutic trials","volume":"12","author":"Beghi","year":"2011","journal-title":"Amyotroph. Lateral Scler."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrneurol.2013.203","article-title":"The epidemiology of ALS: A conspiracy of genes, environment and time","volume":"9","author":"Hardiman","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1474-4422(12)70043-1","article-title":"Frequency of the C9ORF72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: A cross-sectional study","volume":"11","author":"Majounie","year":"2012","journal-title":"Lancet Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Lorson, C.L., Rindt, H., and Shababi, M. (2010). Spinal muscular atrophy: Mechanisms and therapeutic strategies. Hum. Mol. Genet., 19.","DOI":"10.1093\/hmg\/ddq147"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/ajmg.a.33474","article-title":"Newborn and carrier screening for spinal muscular atrophy","volume":"152A","author":"Prior","year":"2010","journal-title":"Am. J. Med. Genet. A"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1177\/0883073807305673","article-title":"Spinal muscular atrophy: Clinical classification and disease heterogeneity","volume":"22","author":"Russman","year":"2007","journal-title":"J. Child Neurol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/ng0797-265","article-title":"Correlation between severity and smn protein level in spinal muscular atrophy","volume":"16","author":"Lefebvre","year":"1997","journal-title":"Nat. Genet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/hmg\/8.7.1177","article-title":"A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2","volume":"8","author":"Monani","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.2353\/ajpath.2007.070399","article-title":"Refined characterization of the expression and stability of the smn gene products","volume":"171","author":"Vitte","year":"2007","journal-title":"Am. J. Pathol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1177\/0883073807305788","article-title":"Consensus statement for standard of care in spinal muscular atrophy","volume":"22","author":"Wang","year":"2007","journal-title":"J. Child Neurol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1097\/WCO.0b013e32833e1765","article-title":"The genetics of spinal muscular atrophies","volume":"23","author":"Wee","year":"2010","journal-title":"Curr. Opin. Neurol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Corti, S., Nizzardo, M., Simone, C., Falcone, M., Nardini, M., Ronchi, D., Donadoni, C., Salani, S., Riboldi, G., and Magri, F. (2012). Genetic correction of human induced pluripotent stem cells from patients with spinal muscular atrophy. Sci. Transl. Med., 4.","DOI":"10.1126\/scitranslmed.3004108"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/B978-0-444-59544-7.00015-9","article-title":"Generation of motor neurons from pluripotent stem cells","volume":"201","author":"Chipman","year":"2012","journal-title":"Prog. Brain Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nn.3425","article-title":"Opportunities and challenges of pluripotent stem cell neurodegenerative disease models","volume":"16","author":"Sandoe","year":"2013","journal-title":"Nat. Neurosci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.stem.2013.01.009","article-title":"Modeling alzheimer\u2019s disease with ipscs reveals stress phenotypes associated with intracellular abeta and differential drug responsiveness","volume":"12","author":"Kondo","year":"2013","journal-title":"Cell Stem Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nbd.2011.12.042","article-title":"The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous huntington\u2019s disease patients demonstrates mutation related enhanced lysosomal activity","volume":"46","author":"Camnasio","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1126\/science.1245296","article-title":"Identification and rescue of alpha-synuclein toxicity in parkinson patient-derived neurons","volume":"342","author":"Chung","year":"2013","journal-title":"Science"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.stem.2014.03.004","article-title":"Pathways disrupted in human ALS motor neurons identified through genetic correction of mutant SOD1","volume":"14","author":"Kiskinis","year":"2014","journal-title":"Cell Stem Cell"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1212\/01.wnl.0000437305.37850.f9","article-title":"Quality improvement in neurology: Amyotrophic lateral sclerosis quality measures: Report of the quality measurement and reporting subcommittee of the american academy of neurology","volume":"81","author":"Miller","year":"2013","journal-title":"Neurology"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Tovar, Y.R.L.B., Ramirez-Jarquin, U.N., Lazo-Gomez, R., and Tapia, R. (2014). Trophic factors as modulators of motor neuron physiology and survival: Implications for ALS therapy. Front. Cell. Neurosci., 8.","DOI":"10.3389\/fncel.2014.00061"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s00401-012-1058-5","article-title":"Unravelling the enigma of selective vulnerability in neurodegeneration: Motor neurons resistant to degeneration in als show distinct gene expression characteristics and decreased susceptibility to excitotoxicity","volume":"125","author":"Brockington","year":"2013","journal-title":"Acta Neuropathol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/ana.24012","article-title":"Amyotrophic lateral sclerosis: Problems and prospects","volume":"74","author":"Sreedharan","year":"2013","journal-title":"Ann. Neurol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.tins.2014.05.006","article-title":"Advances in treating amyotrophic lateral sclerosis: Insights from pathophysiological studies","volume":"37","author":"Vucic","year":"2014","journal-title":"Trends Neurosci."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/ajmg.1320510114","article-title":"Genetic linkage analysis of familial amyotrophic lateral sclerosis using human chromosome 21 microsatellite DNA markers","volume":"51","author":"Rosen","year":"1994","journal-title":"Am. J. Med. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"Mackenzie","year":"2011","journal-title":"Neuron"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/mus.24198","article-title":"Genetic heterogeneity of amyotrophic lateral sclerosis: Implications for clinical practice and research","volume":"49","author":"Su","year":"2014","journal-title":"Muscle Nerve"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.neuron.2013.07.033","article-title":"Converging mechanisms in ALS and FTD: Disrupted RNA and protein homeostasis","volume":"79","author":"Ling","year":"2013","journal-title":"Neuron"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nn.3584","article-title":"State of play in amyotrophic lateral sclerosis genetics","volume":"17","author":"Renton","year":"2014","journal-title":"Nat. Neurosci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.stem.2008.09.017","article-title":"Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation","volume":"3","author":"Boulting","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.celrep.2014.03.019","article-title":"Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons","volume":"7","author":"Wainger","year":"2014","journal-title":"Cell Rep."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Sareen, D., O\u2019Rourke, J.G., Meera, P., Muhammad, A.K., Grant, S., Simpkinson, M., Bell, S., Carmona, S., Ornelas, L., and Sahabian, A. (2013). Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Sci. Transl. Med., 5.","DOI":"10.1126\/scitranslmed.3007529"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"37572","DOI":"10.1074\/jbc.M505557200","article-title":"TDP-43 binds heterogeneous nuclear ribonucleoprotein A\/B through its C-terminal tail","volume":"280","author":"Buratti","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"5803","DOI":"10.1073\/pnas.1202922109","article-title":"Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability","volume":"109","author":"Bilican","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.neuron.2013.12.018","article-title":"Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations","volume":"81","author":"Alami","year":"2014","journal-title":"Neuron"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.stem.2014.02.004","article-title":"Modeling als with ipscs reveals that mutant SOD1 misregulates neurofilament balance in motor neurons","volume":"14","author":"Chen","year":"2014","journal-title":"Cell Stem Cell"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Poppe, L., Rue, L., Robberecht, W., and van Den Bosch, L. (2014). Translating biological findings into new treatment strategies for amyotrophic lateral sclerosis (ALS). Exp. Neurol.","DOI":"10.1016\/j.expneurol.2014.07.001"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Egawa, N., Kitaoka, S., Tsukita, K., Naitoh, M., Takahashi, K., Yamamoto, T., Adachi, F., Kondo, T., Okita, K., and Asaka, I. (2012). Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci. Transl. Med., 4.","DOI":"10.1126\/scitranslmed.3004052"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.stemcr.2014.05.017","article-title":"Focal transplantation of human iPSC-derived glial-rich neural progenitors improves lifespan of als mice","volume":"3","author":"Kondo","year":"2014","journal-title":"Stem Cell Rep."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature07677","article-title":"Induced pluripotent stem cells from a spinal muscular atrophy patient","volume":"457","author":"Ebert","year":"2009","journal-title":"Nature"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e39113","DOI":"10.1371\/journal.pone.0039113","article-title":"Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy","volume":"7","author":"Sareen","year":"2012","journal-title":"PLoS One"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/glia.22522","article-title":"Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production","volume":"61","author":"McGivern","year":"2013","journal-title":"Glia"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e13638","DOI":"10.1371\/journal.pone.0013638","article-title":"Caspase-10-dependent cell death in Fas\/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk","volume":"5","author":"Lafont","year":"2010","journal-title":"PLoS One"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.cell.2008.03.031","article-title":"SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing","volume":"133","author":"Zhang","year":"2008","journal-title":"Cell"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e1000773","DOI":"10.1371\/journal.pgen.1000773","article-title":"Alternative splicing events are a late feature of pathology in a mouse model of spinal muscular atrophy","volume":"5","author":"Baumer","year":"2009","journal-title":"PLoS Genet."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fncel.2014.00117","article-title":"Microglia centered pathogenesis in als: Insights in cell interconnectivity","volume":"8","author":"Brites","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/glia.22428","article-title":"Altered astrocytic response to activation in SOD1(G93A) mice and its implications on amyotrophic lateral sclerosis pathogenesis","volume":"61","author":"Benkler","year":"2013","journal-title":"Glia"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.parkreldis.2004.10.013","article-title":"Neuroinflammatory processes in parkinson\u2019s disease","volume":"11","author":"Hirsch","year":"2005","journal-title":"Park. Relat. Disord."},{"key":"ref_57","first-page":"342","article-title":"The astrocyte odyssey","volume":"86","author":"Wang","year":"2008","journal-title":"Prog. Neurobiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1093\/hmg\/dds437","article-title":"VPA response in sma is suppressed by the fatty acid translocase CD36","volume":"22","author":"Garbes","year":"2013","journal-title":"Hum. Mol. Genet."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Van Den Bosch, L. (2011). Genetic rodent models of amyotrophic lateral sclerosis. J. Biomed. Biotechnol., 2011.","DOI":"10.1155\/2011\/348765"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1177\/0883073807305667","article-title":"Animal models of spinal muscular atrophy","volume":"22","author":"Schmid","year":"2007","journal-title":"J. Child Neurol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.neuron.2014.01.011","article-title":"Necroptosis drives motor neuron death in models of both sporadic and familial ALS","volume":"81","author":"Re","year":"2014","journal-title":"Neuron"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"15","DOI":"10.32607\/20758251-2013-5-4-15-21","article-title":"\u201cEpigenetic memory\u201d phenomenon in induced pluripotent stem cells","volume":"5","author":"Vaskova","year":"2013","journal-title":"Acta Naturae"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00702-013-1042-9","article-title":"Induced neural stem cells (iNSCs) in neurodegenerative diseases","volume":"120","author":"Hermann","year":"2013","journal-title":"J. Neural Transm."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/3\/4\/1124\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T21:17:07Z","timestamp":1760217427000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/3\/4\/1124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,17]]},"references-count":63,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,12]]}},"alternative-id":["jcm3041124"],"URL":"https:\/\/doi.org\/10.3390\/jcm3041124","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,17]]}}}