{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:23:28Z","timestamp":1760243008824,"version":"build-2065373602"},"reference-count":9,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T00:00:00Z","timestamp":1431648000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>We report a case of a previously undiagnosed panhypopituitarism initially presenting as a full-blown Addisonian crisis with hypoglycemia, hyponatremia, hypotension and neuropsychological symptoms, more than 30 years after a severe traumatic brain injury (TBI). The patient also displayed clearly visible pathognomonic clinical signs of long-standing pituitary dysfunction. The case highlights the importance of being aware of endocrine sequelae even decades after serious TBI.<\/jats:p>","DOI":"10.3390\/jcm4050965","type":"journal-article","created":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T07:57:02Z","timestamp":1431676622000},"page":"965-969","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Addisonian Crisis after Missed Diagnosis of  Posttraumatic Hypopituitarism"],"prefix":"10.3390","volume":"4","author":[{"given":"Christine","family":"Streetz-van der Werf","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Diabetes, RWTH Aachen University, 52062 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfram","family":"Karges","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Diabetes, RWTH Aachen University, 52062 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Blaum","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, RWTH Aachen University, 52062 Aachen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilonka","family":"Kreitschmann-Andermahr","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University Hospital Essen, 45147 Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2015,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ecl.2014.10.012","article-title":"Hypopituitarism after traumatic brain injury","volume":"44","author":"Bernabeu","year":"2015","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/S0140-6736(07)60673-4","article-title":"Hypopituitarism","volume":"369","author":"Schneider","year":"2007","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1001\/jama.298.12.1429","article-title":"Hypothalamopituitary dysfunction following traumatic brain injury and aneurysmal subarachnoid hemorrhage: A systematic review","volume":"298","author":"Schneider","year":"2007","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1258\/j.jmb.2007.06-13","article-title":"Eponymous, anonymous: Queen Anne\u2019s sign and the misnaming of a symptom","volume":"15","year":"2007","journal-title":"J. Med. Biogr."},{"key":"ref_5","first-page":"1261","article-title":"Pituitary damage due to basal skull fracture (in German)","volume":"44","author":"Cyran","year":"1918","journal-title":"Dtsch. Med. Wochenschr."},{"key":"ref_6","first-page":"523","article-title":"Hypophyseal-hypothalamic symptoms after blunt cranial trauma (in German)","volume":"25","author":"Witter","year":"1957","journal-title":"Fortschr. Neurol. Psychiatr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1530\/EJE-14-1069","article-title":"Patient reported out-come in posttraumatic pituitary deficiency: Results from the Danish National Study on posttraumatic hypopituitarism","volume":"172","author":"Klose","year":"2015","journal-title":"Eur. J. Endocrinol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1365-2265.2006.02517.x","article-title":"Anterior pituitary dysfunction following traumatic brain injury (TBI)","volume":"64","author":"Agha","year":"2006","journal-title":"Clin. Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1016\/S0140-6736(03)13492-7","article-title":"Adrenal insufficiency","volume":"361","author":"Arlt","year":"2003","journal-title":"Lancet"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/4\/5\/965\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T20:46:25Z","timestamp":1760215585000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/4\/5\/965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,15]]},"references-count":9,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2015,5]]}},"alternative-id":["jcm4050965"],"URL":"https:\/\/doi.org\/10.3390\/jcm4050965","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2015,5,15]]}}}