{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:16:08Z","timestamp":1785330968621,"version":"3.55.0"},"reference-count":51,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Behcet\u2019s disease (BD) is a polysymptomatic and recurrent systemic vasculitis with a chronic course and unknown cause. The pathogenesis of BD has not been fully elucidated; however, BD has been considered to be a typical Th1-mediated inflammatory disease, characterized by elevated levels of Th1 cytokines such as IFN-\u03b3, IL-2, and TNF-\u03b1. Recently, some studies reported that Th17-associated cytokines were increased in BD; thus, Th17 cells and the IL17\/IL23 pathway may play important roles in the pathogenesis of BD. In this chapter, we focus on the pathogenic role of Th17 cells in BD.<\/jats:p>","DOI":"10.3390\/jcm6070074","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T10:45:48Z","timestamp":1500633948000},"page":"74","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["The Role of Th17 Cells in the Pathogenesis of Behcet\u2019s Disease"],"prefix":"10.3390","volume":"6","author":[{"given":"Yuki","family":"Nanke","sequence":"first","affiliation":[{"name":"Institute of Rheumatology, Tokyo Women\u2019s Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1393-8615","authenticated-orcid":false,"given":"Toru","family":"Yago","sequence":"additional","affiliation":[{"name":"Institute of Rheumatology, Tokyo Women\u2019s Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kotake","sequence":"additional","affiliation":[{"name":"Institute of Rheumatology, Tokyo Women\u2019s Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3109\/s10165-002-0213-6","article-title":"Raised plasma adrenomedullin level in Behcet\u2019s disease patients","volume":"13","author":"Nanke","year":"2003","journal-title":"Mod. 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