{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:10:41Z","timestamp":1787893841074,"version":"build-2784847793"},"reference-count":60,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2017,7,31]],"date-time":"2017-07-31T00:00:00Z","timestamp":1501459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Joint bleeding represents the most commonly reported type of hemorrhage in patients affected by hemophilia. Although the widespread use of prophylaxis has been able to significantly reduce the onset of arthropathy, it has been shown that a non-negligible percentage of patients develop degenerative changes in their joints despite this type of treatment. Thus, periodic monitoring of the joint status in hemophilia patients has been recommended to identify early arthropathic changes and prevent the development or progression of hemophilic arthropathy. Ultrasound (US) has proven able to detect and quantify the most relevant biomarkers of disease activity (i.e., joint effusion and synovial hypertrophy) and degenerative damages (i.e., osteo-chondral changes) by means of scoring scales of increasing disease severity. In the present review, we have detailed major literature evidence about the use of US to assess joint status in hemophilia patients, focusing on signs of disease activity and degenerative damages. In particular, we have discussed recent evidence about \u201cpoint-of-care\u201d use patients with hemophilia.<\/jats:p>","DOI":"10.3390\/jcm6080077","type":"journal-article","created":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T03:30:06Z","timestamp":1501558206000},"page":"77","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Ultrasound for Early Detection of Joint Disease in Patients with Hemophilic Arthropathy"],"prefix":"10.3390","volume":"6","author":[{"given":"Matteo","family":"Di Minno","sequence":"first","affiliation":[{"name":"Department of Advanced Biomedical Sciences, Federico II University, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Pasta","sequence":"additional","affiliation":[{"name":"Dipartimento di Ortopedia\u2014Fondazione IRCCS Ca\u2019 Granda, Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Airaldi","sequence":"additional","affiliation":[{"name":"Radiologia III\u2014IRCCS San Martino-IST\u2014DISSAL, Universit\u00e0 di Genova, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Zaottini","sequence":"additional","affiliation":[{"name":"Radiologia III\u2014IRCCS San Martino-IST\u2014DISSAL, Universit\u00e0 di Genova, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Storino","sequence":"additional","affiliation":[{"name":"Department of Public Health, Federico II University, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Cimino","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Martinoli","sequence":"additional","affiliation":[{"name":"Radiologia III\u2014IRCCS San Martino-IST\u2014DISSAL, Universit\u00e0 di Genova, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,7,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/S0140-6736(03)13405-8","article-title":"Hemophilias A and B","volume":"361","author":"Pasi","year":"2003","journal-title":"Lancet"},{"key":"ref_2","first-page":"205","article-title":"Hemophilic arthropathy: Evaluation of clinical and radiological characteristics and disability","volume":"42","author":"Dalyan","year":"2000","journal-title":"Turk. 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