{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:06:36Z","timestamp":1761156396654,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Today, major surgical procedures can be safely performed in hemophilic patients with chronic arthropathy, using available factor concentrates. In this setting, total knee replacement is considered the \u201cgold standard\u201d, while the use of total ankle replacement is still debated. Indeed, the unsatisfactory results obtained with the previous available design of implants did not raise enthusiasm as knee or hip replacement. Recently, the introduction of new implant designs and better reported outcomes have renewed the interest in total ankle replacement in people with hemophilia. In this review, the role of replacement surgery in the treatment of chronic hemophilic arthropathy will be described.<\/jats:p>","DOI":"10.3390\/jcm6110107","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T10:47:38Z","timestamp":1511347658000},"page":"107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Knee and Ankle Arthroplasty in Hemophilia"],"prefix":"10.3390","volume":"6","author":[{"given":"Luigi","family":"Solimeno","sequence":"first","affiliation":[{"name":"Division of Orthopaedic Surgery and Traumatology, Fondazione IRCCS Ca\u2019 Granda, Ospedale Maggiore Policlinico, Via F. Sforza, 28, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Pasta","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Surgery and Traumatology, Fondazione IRCCS Ca\u2019 Granda, Ospedale Maggiore Policlinico, Via F. Sforza, 28, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1182\/blood-2003-12-4231","article-title":"Pathobiology of hemophilic synovitis I: Overexpression of mdm2 oncogene","volume":"104","author":"Hakobyan","year":"2004","journal-title":"Blood"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1365-2516.2004.00899.x","article-title":"Experimental haemophilic synovitis: Rationale and development of a murine model of human factor VIII deficiency","volume":"10","author":"Valentino","year":"2004","journal-title":"Haemophilia"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1749-6632.1975.tb53362.x","article-title":"Biochemical and physiological aspects of degenerative joint disease with special reference to hemophilic arthropathy","volume":"240","author":"Sokoloff","year":"1975","journal-title":"Am. N. Y. Acad. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1302\/0301-620X.80B3.0800540","article-title":"Iron deposits and catabolic properties of synovial tissue from patients with haemophilia","volume":"80-B","author":"Roosendaal","year":"1998","journal-title":"J. Bone Jt. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/00003086-199607000-00009","article-title":"Haemophilic ankle arthropathy","volume":"328","author":"Ribbans","year":"1996","journal-title":"Clin. Orthop."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1136\/bmj.1.6161.469","article-title":"Patterns of bleeding in adolescents with severe haemophilia A","volume":"1","author":"Aronstam","year":"1979","journal-title":"BMJ"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1365-2516.2010.02308.x","article-title":"Management of arthrofibrosis in haemophilic arthropathy","volume":"16","author":"Solimeno","year":"2010","journal-title":"Haemophilia"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Harvey, L.A., Brosseau, L., and Herbert, R.D. (2010). Continous passive motion following total knee arthroplasty in people with arthritis (Review). Cochrane Database Syst. Rev., 3.","DOI":"10.1002\/14651858.CD004260.pub2"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1111\/j.1365-2516.2008.01748.x","article-title":"The role of physiotherapy after total knee arthroplasty in patients with Haemophilia","volume":"14","author":"Lobet","year":"2008","journal-title":"Haemophilia"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2141.2009.07613.x","article-title":"Factors influencing the long-term out come of primary total knee replacement in haemophiliacs: A review of 116 procedures at a single institution","volume":"145","author":"Solimeno","year":"2009","journal-title":"Br. J. Haematol."},{"key":"ref_11","first-page":"503","article-title":"Total knee arthroplasty in hemophilic arthropathy","volume":"44","year":"2015","journal-title":"Am. J. Orthop."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1302\/0301-620X.89B2.18682","article-title":"Total knee replacement in haemophilic arthropathy","volume":"89-B","year":"2007","journal-title":"J. Bone Jt. Surg. Br."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1586\/17474086.2013.856261","article-title":"Special features of total knee replacement in haemophilia","volume":"6","year":"2013","journal-title":"Expert Rev. Hematol."},{"key":"ref_14","first-page":"831","article-title":"Infection after total knee arthroplasty in haemophilic arthropathy with special emphasis on late infection","volume":"17","year":"2011","journal-title":"Haemophilia"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Wong, J.M.L., Mann, H.A., and Goddard, N.J. (2012). Perioperative clotting factor replacement and infection in total knee arthroplasty. Haemophilia, 607\u2013612.","DOI":"10.1111\/j.1365-2516.2011.02728.x"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/MBC.0b013e32835553dd","article-title":"Preventing surgical site infection in haemophilia patients undergoing total knee arthroplasty","volume":"23","year":"2012","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3928\/01477447-20100722-42","article-title":"Periprosthetic joint infection: Treatment options","volume":"33","author":"Parvizi","year":"2010","journal-title":"Orthopedics"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.arth.2004.03.001","article-title":"The infected total knee arthroplasty: Just when you thought it was over","volume":"19","author":"Buechel","year":"2004","journal-title":"J. Arthroplasty"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1302\/0301-620X.76B6.7983125","article-title":"Supramalleolar tibial osteotomy for haemophilic arthropathy of the ankle","volume":"76-B","author":"Pearce","year":"1994","journal-title":"J. Bone Jt. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.2106\/JBJS.E.00414","article-title":"Total ankle arthroplasty in inflammatory joint disease with use of two mobile-bearing designs","volume":"88-A","author":"Doets","year":"2006","journal-title":"J. Bone Jt. Surg."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1365-2516.2006.01350.x","article-title":"The feasibility of total ankle prosthesis for severe arthropathy in haemophilia and prothrombin deficiency","volume":"12","author":"Novakova","year":"2006","journal-title":"Haemophilia"},{"key":"ref_22","unstructured":"Radossi, P., Bisson, R., Petris, U., De Biasi, E., Risato, R., Roveroni, G., Sartori, R., Tassinari, C., and Tagariello, G. Total ankle replacement for end-stage arthropathy in hemophiliacs: Report of two cases."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.fas.2014.08.004","article-title":"Short-term and mid-term outcome of total ankle replacement in haemophilic patients","volume":"20","author":"Asencio","year":"2014","journal-title":"Foot Ankle Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1365-2516.2010.02221.x","article-title":"Haemophilic arthropathy of the ankle treated by total ankle replacement: A case series","volume":"16","author":"Barg","year":"2010","journal-title":"Haemophilia"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/hae.12392","article-title":"Total ankle replacement in patients with haemophilia and virus infections\u2014A safe alternative to ankle arthrodesis?","volume":"20","author":"Strauss","year":"2014","journal-title":"Haemophilia"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1586\/17474086.2015.1087846","article-title":"Total ankle replacement or ankle fusion in painful advanced hemophilic arthopathy of the ankle","volume":"8","year":"2015","journal-title":"Expert Rev. Hematol."},{"key":"ref_27","first-page":"106","article-title":"End-stage haemophilic arthropathy of the ankle: Ankle fusion or total ankle replacement","volume":"20","year":"2014","journal-title":"Haemophilia"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/6\/11\/107\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:50:42Z","timestamp":1760208642000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/6\/11\/107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,22]]},"references-count":27,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2017,11]]}},"alternative-id":["jcm6110107"],"URL":"https:\/\/doi.org\/10.3390\/jcm6110107","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2017,11,22]]}}}