{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:58:27Z","timestamp":1773295107924,"version":"3.50.1"},"reference-count":7,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2017,12,25]],"date-time":"2017-12-25T00:00:00Z","timestamp":1514160000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Cyclic edema is a clinical condition in women that leads to fluid retention in the orthostatic position. The aim of the present study was to evaluate the prevalence of idiopathic cyclic edema in women with lower limb lymphedema. The prevalence of idiopathic cyclic edema was evaluated in a retrospective study of 100 consecutive female patients submitted to leg lymphedema treatment at the Cl\u00ednica Godoy. The diagnosis of lymphedema was clinical, based on patient history and a physical examination. Patients with clinical stage II lymphedema were included in the study with those in stages I and III being excluded. The diagnosis of idiopathic cyclic edema was based on the patient\u2019s history and fluid retention of more than one kilogram between 7:00 a.m. and 5:00 p.m. Clinical signs of this disease include difficulty removing rings in the morning that becomes easier during the course of the day, waking up with a swollen face, and abdominal discomfort during the day. After diagnosing cyclic edema, a therapeutic test was performed using aminaphtone or calcium dobesilate with which fluid retention was reduced to less than 300 g during the same period. The patients were instructed to drink liquids only when they were thirsty.<\/jats:p>","DOI":"10.3390\/jcm7010002","type":"journal-article","created":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T03:06:38Z","timestamp":1514257598000},"page":"2","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prevalence of Idiopathic Cyclic Edema in Women with Lower Limb Lymphedema"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5424-7787","authenticated-orcid":false,"given":"Jose","family":"Pereira de Godoy","sequence":"first","affiliation":[{"name":"Department of Cardiology and Cardiovascular Surgery, Medicine School in S\u00e3o Jos\u00e9 do Rio Preto (FAMERP), CNPq (National Council for Research and Development), S\u00e3o Jos\u00e9 do Rio Preto 15025120, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique","family":"Pereira de Godoy","sequence":"additional","affiliation":[{"name":"Medicine School of Universidade Federal do Mato Grosso-Cuiab\u00e1-UFMT and Research Group in the Cl\u00ednica Godoy, S\u00e3o Jos\u00e9 do Rio Preto 15025120, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edvia","family":"Pereira de Godoy","sequence":"additional","affiliation":[{"name":"Clinic General in Medicine School of Marilia-S\u00e3o Paulo-Brazil (FANEMA) and Researcher Group of the Cl\u00ednica Godoy, S\u00e3o Jos\u00e9 do Rio Preto 15025120, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3725-7961","authenticated-orcid":false,"given":"Maria","family":"Guerreiro Godoy","sequence":"additional","affiliation":[{"name":"Occupational Therapist Professor of the Post-Graduate Strictu Sensu in Medicine School in S\u00e3o Jos\u00e9 do Rio Preto (FAMERP) and Research Group in the Cl\u00ednica Godoy, S\u00e3o Jos\u00e9 do Rio Preto 15025120, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,12,25]]},"reference":[{"key":"ref_1","first-page":"494","article-title":"Intensive outpatient treatment of elephantiasis","volume":"31","author":"Buzato","year":"2012","journal-title":"Int. Angiol."},{"key":"ref_2","first-page":"311","article-title":"Iua-Isvi consensus for diagnosis guideline of chronic lymphedema of the limbs","volume":"34","author":"Lee","year":"2015","journal-title":"Int. Angiol."},{"key":"ref_3","first-page":"62","article-title":"Development and evaluation of a new apparatus for lymph drainage: Preliminary results","volume":"37","author":"Godoy","year":"2004","journal-title":"Lymphology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1007\/s00108-013-3339-z","article-title":"Leg swelling","volume":"54","author":"Schellong","year":"2013","journal-title":"Internist"},{"key":"ref_5","first-page":"43","article-title":"Analysis of lymphatic drainage in various forms of leg edema using two compartment lymphoscintigraphy","volume":"31","author":"Schaiper","year":"1998","journal-title":"Lymphology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1258\/phleb.2007.007054","article-title":"Aminaphtone in idiopathic cyclic oedema syndrome","volume":"23","year":"2008","journal-title":"Phlebology"},{"key":"ref_7","first-page":"5470909","article-title":"Lipolymphedema associated with idiopathic cyclic edema: A therapeutic approach","volume":"2017","year":"2017","journal-title":"Case Rep. Vasc. Med."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/7\/1\/2\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:55:25Z","timestamp":1760208925000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/7\/1\/2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,25]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1]]}},"alternative-id":["jcm7010002"],"URL":"https:\/\/doi.org\/10.3390\/jcm7010002","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,25]]}}}