{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:25:32Z","timestamp":1783394732808,"version":"3.54.6"},"reference-count":17,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,1,2]],"date-time":"2018-01-02T00:00:00Z","timestamp":1514851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: The aim of this study was to clarify the association of maternal factors with perinatal complications in pregnancies complicated with type 1 (T1D) or type 2 diabetes (T2D). Methods: We conducted a retrospective chart review and enrolled 26 Japanese pregnant women with diabetes who received perinatal care at our hospital between 2008 and 2015. Perinatal complications were defined as one or more of the following: miscarriage, fetal death, fetal dysfunction, fetal structural anomaly, small-for-gestational age, large-for-gestational age (LGA), premature birth, neonatal hypoglycemia, pregnancy-induced hypertension (PIH), deterioration of maternal kidney function, and urgent Caesarean section (CS). The associations between perinatal complications and maternal factors were examined. Results: Approximately 70% and 50% of women with T1D and T2D experienced perinatal complications, respectively. LGA, neonatal hypoglycemia, and urgent CS were major perinatal complications in women with T1D, while PIH and urgent CS were major complications in those with T2D. In women with T1D, pre-gestational HbA1c was significantly higher in women with perinatal complications than in those without. In women with T2D, pre-gestational body mass index was significantly higher in women with perinatal complications than in those without. Conclusions: These findings suggest that while pre-gestational glycemic control remains the most important issue in women with T1D, pre-gestational weight control in addition to glycemic control should be greater emphasized in women with T2D to reduce the risk of perinatal complications.<\/jats:p>","DOI":"10.3390\/jcm7010005","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T12:00:06Z","timestamp":1514980806000},"page":"5","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association of Maternal Factors with Perinatal Complications in Pregnancies Complicated with Diabetes: A Single-Center Retrospective Analysis"],"prefix":"10.3390","volume":"7","author":[{"given":"Sho","family":"Endo","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Saisho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Miyakoshi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daigo","family":"Ochiai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinaga","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Mitsuishi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2662-4121","authenticated-orcid":false,"given":"Junichiro","family":"Irie","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Meguro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamoru","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Itoh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"HAPO Study Cooperative Research Group (2008). Hyperglycemia and adverse pregnancy outcomes. N. Engl. J. Med., 358, 1991\u20132002.","DOI":"10.1056\/NEJMoa0707943"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.diabres.2007.11.009","article-title":"Pregnancy complicated by type 2 diabetes: An emerging problem","volume":"80","author":"Lapolla","year":"2008","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Owens, L.A., Sedar, J., Carmody, L., and Dunne, F. (2015). Comparing type 1 and type 2 diabetes in pregnancy\u2014Similar conditions or is a separate approach required?. BMC Pregnancy Childbirth, 15.","DOI":"10.1186\/s12884-015-0499-y"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/ped.12331","article-title":"New Japanese neonatal anthropometric charts for gestational age at birth","volume":"56","author":"Itabashi","year":"2014","journal-title":"Pediatr. Int."},{"key":"ref_5","first-page":"61","article-title":"Pregnancy induced hypertension","volume":"58","author":"Itoh","year":"2006","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1111\/jog.12419","article-title":"Guidelines for obstetrical practice in Japan: Japan Society of Obstetrics and Gynecology (JSOG) and Japan Association of Obstetricians and Gynecologists (JAOG) 2014 edition","volume":"40","author":"Minakami","year":"2014","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1507\/endocrj.EJ14-0140","article-title":"Pregnancy outcomes in women with type 1 and type 2 diabetes mellitus in a retrospective multi-institutional study in Japan","volume":"61","author":"Sato","year":"2014","journal-title":"Endocr. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1016\/j.ajog.2004.12.049","article-title":"Overweight and obese in gestational diabetes: The impact on pregnancy outcome","volume":"192","author":"Langer","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Bhattacharya, S., Campbell, D.M., Liston, W.A., and Bhattacharya, S. (2007). Effect of Body Mass Index on pregnancy outcomes in nulliparous women delivering singleton babies. BMC Public Health, 7.","DOI":"10.1186\/1471-2458-7-168"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s13224-012-0225-x","article-title":"Effect of body mass index on pregnancy outcomes in nulliparous women delivering singleton babies: Observational study","volume":"62","author":"Jain","year":"2012","journal-title":"J. Obstet. Gynaecol. India"},{"key":"ref_11","first-page":"1531","article-title":"Maternal Body Mass Index and pregnancy outcome","volume":"6","author":"Verma","year":"2012","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1111\/j.1447-0756.2011.01552.x","article-title":"Impact of maternal age on the incidence of obstetrical complications in Japan","volume":"37","author":"Matsuda","year":"2011","journal-title":"J. Obstet. Gynecol. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.ajog.2003.09.058","article-title":"Obesity, obstetric complications and cesarean delivery rate\u2014A population based screening study","volume":"190","author":"Weiss","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"ACOG Committee on Practice Bulletins (2005). ACOG practice bulletin. Clinical management guidelines for obstetrician-gynecologists. Number 60, March 2005. Pregestational diabetes mellitus. Obstet. Gynecol., 105, 675\u2013685.","DOI":"10.1097\/00006250-200503000-00049"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4284","DOI":"10.1210\/jc.2009-1231","article-title":"Maternal and fetal outcome in women with type 2 versus type 1 diabetes mellitus: A systematic review and metaanalysis","volume":"94","author":"Balsells","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1089\/jwh.2010.2033","article-title":"Risk factor profile and pregnancy outcome in women with type 1 and type 2 diabetes mellitus","volume":"20","author":"Handisurya","year":"2011","journal-title":"J. Womens Health"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0168-8227(94)90261-5","article-title":"Current status of pregnancy in diabetic women. A comparison of pregnancy in IDDM and NIDDM mothers","volume":"24","author":"Omori","year":"1994","journal-title":"Diabetes Res. Clin. Pract."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/7\/1\/5\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T14:49:51Z","timestamp":1760194191000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/7\/1\/5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,2]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1]]}},"alternative-id":["jcm7010005"],"URL":"https:\/\/doi.org\/10.3390\/jcm7010005","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,2]]}}}