{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:21:16Z","timestamp":1782231676571,"version":"3.54.5"},"reference-count":51,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T00:00:00Z","timestamp":1528675200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: To review the current published literature on the use of procalcitonin as a diagnostic and prognostic marker in adult patients with meningitis. Methods: We conducted a PubMed search to identify all relevant publications regarding the diagnostic and prognostic value of serum procalcitonin in patients with a known or suspected central nervous system infection. We also reviewed the bibliographies of all identified manuscripts in an attempt to identify additional relevant references. Results: A significant body of evidence suggests that serum procalcitonin has a promising role and can be a useful biomarker in the assessment of patients with meningitis. Conclusions: Our literature review suggests that data on the role of Cerebrospinal Fluid (CSF) procalcitonin are limited, whereas serum procalcitonin (S\u2013PCT) is probably a useful tool in the evaluation of patients with a known or suspected central nervous system infection and can help distinguish between bacterial and viral meningitis.<\/jats:p>","DOI":"10.3390\/jcm7060148","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T11:01:01Z","timestamp":1528714861000},"page":"148","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The Role of Procalcitonin in the Diagnosis of Meningitis: A Literature Review"],"prefix":"10.3390","volume":"7","author":[{"given":"Dimitrios","family":"Velissaris","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Patras, 26504 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Pintea","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy, 400337 Cluj-Napoca, Rom\u00e2nia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Pantzaris","sequence":"additional","affiliation":[{"name":"School of Medicine University of Patras, 26500 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Spatha","sequence":"additional","affiliation":[{"name":"School of Medicine University of Patras, 26500 Patras, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilios","family":"Karamouzos","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, University Hospital of Patras, Rion 26500, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalampos","family":"Pierrakos","sequence":"additional","affiliation":[{"name":"Intensive Care Department, Brugmann University Hospital, 1020 Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8541-7988","authenticated-orcid":false,"given":"Menelaos","family":"Karanikolas","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63144, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,6,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1186\/cc8872","article-title":"Sepsis biomarkers: A review","volume":"14","author":"Pierrakos","year":"2010","journal-title":"Crit Care"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.1097\/CCM.0b013e3181a02afc","article-title":"Biomarkers of sepsis","volume":"37","author":"Marshall","year":"2009","journal-title":"Crit. 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