{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T06:57:36Z","timestamp":1760597856681,"version":"build-2065373602"},"reference-count":11,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,12,23]],"date-time":"2018-12-23T00:00:00Z","timestamp":1545523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>A 78-year-old man with 3 months of progressive dyspnea, dysphony, dysgeusia, and proximal muscle weakness was diagnosed of probably idiopathic inflammatory myopathy with nonspecific interstitial pneumonia. Variable degrees of atrioventricular block and persistently elevated cardiac enzymes indicated a diagnosis of myocarditis, confirmed with cardiac magnetic resonance imaging and endomyocardial biopsy. A comprehensive immune work-up revealed anti-small ubiquitin-like modifier-1 activating enzyme (anti-SAE) antibody, a novel myositis-specific antibody, previously described mainly with overt cutaneous dermatomyositis and late skeletal muscle manifestations. Here, heart\u2013lung\u2013muscle involvement combined with anti-SAE antibodies was a severe combination.<\/jats:p>","DOI":"10.3390\/jcm8010020","type":"journal-article","created":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T10:37:49Z","timestamp":1545647869000},"page":"20","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Heart\u2013Lung\u2013Muscle Anti-SAE Syndrome: An Atypical Severe Combination"],"prefix":"10.3390","volume":"8","author":[{"given":"Elisabet","family":"Zamora","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain"},{"name":"Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"},{"name":"CIBERCV, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Seder-Colomina","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Holgado","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3875-8074","authenticated-orcid":false,"given":"Bibiana","family":"Quirant-Sanchez","sequence":"additional","affiliation":[{"name":"Immunology Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain"},{"name":"Department of Cell Biology, Physiology and Immunology, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Mate","sequence":"additional","affiliation":[{"name":"Pathology Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva M.","family":"Mart\u00ednez-C\u00e1ceres","sequence":"additional","affiliation":[{"name":"Immunology Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain"},{"name":"Department of Cell Biology, Physiology and Immunology, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivette","family":"Casafont","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Bay\u00e9s-Gen\u00eds","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain"},{"name":"Departament de Medicina, Universitat Aut\u00f2noma de Barcelona, 08193 Bellaterra, Spain"},{"name":"CIBERCV, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/rheumatology\/kel311","article-title":"The heart in dermatomyositis and polymyositis","volume":"45","author":"Lundberg","year":"2006","journal-title":"Rheumatology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jim.2012.07.019","article-title":"Anti-SAE antibodies in autoimmune myositis: Identification by unlabelled protein immunoprecipitation in an Italian patient cohort","volume":"384","author":"Tarricone","year":"2012","journal-title":"J. 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Rheumatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1136\/ard.2008.097162","article-title":"Clinical and human leucocyte antigen class II haplotype associations of autoantibodies to small ubiquitin-like modifier enzyme, a dermatomyositis-specific autoantigen target, in UK Caucasian adult-onset myositis","volume":"68","author":"Betteridge","year":"2009","journal-title":"Ann. Rheum. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1183\/16000617.00002015","article-title":"Idiopathic inflammatory myopathies and the lung","volume":"24","author":"Lega","year":"2015","journal-title":"Eur. Respir. 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Cardiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ijcard.2012.09.109","article-title":"Myocarditis during acute inflammatory myopathies: Evaluation using clinical criteria and cardiac magnetic resonance imaging","volume":"164","author":"Mavrogeni","year":"2013","journal-title":"Int. J. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.recesp.2015.10.018","article-title":"Update on Myocarditis and Inflammatory Cardiomyopathy: Reemergence of Endomyocardial Biopsy","volume":"69","author":"Dominguez","year":"2016","journal-title":"Rev. Espa\u00f1ola Cardiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ijcard.2010.08.013","article-title":"Clinical cardiac involvement in idiopathic inflammatory myopathies: A systematic review","volume":"148","author":"Gupta","year":"2011","journal-title":"Int. J. Cardiol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/1\/20\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:35:49Z","timestamp":1760196949000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/1\/20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,23]]},"references-count":11,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1]]}},"alternative-id":["jcm8010020"],"URL":"https:\/\/doi.org\/10.3390\/jcm8010020","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2018,12,23]]}}}