{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:57:40Z","timestamp":1784329060629,"version":"3.55.0"},"reference-count":42,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,19]],"date-time":"2019-01-19T00:00:00Z","timestamp":1547856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["HL-126638"],"award-info":[{"award-number":["HL-126638"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["18POST3990251"],"award-info":[{"award-number":["18POST3990251"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The measurement of peak oxygen uptake (VO2peak) is an important metric for evaluating cardiac transplantation (HTx) eligibility. However, it is unclear which factors (e.g., recipient demographics, clinical parameters, cardiac rehabilitation (CR) participation) influence VO2peak following HTx. Consecutive HTx patients with cardiopulmonary exercise testing (CPET) between 2007\u20132016 were included. VO2peak was measured from CPET standard protocol. Regression analyses determined predictors of the highest post-HTx VO2peak (i.e., quartile 4: VO2peak &gt; 20.1 mL\/kg\/min). One hundred-forty HTx patients (women: n = 41 (29%), age: 52 \u00b1 12 years, body mass index (BMI): 27 \u00b1 5 kg\/m2) were included. History of diabetes (Odds Ratio (OR): 0.17, 95% Confidence Interval (CI): 0.04\u20130.77, p = 0.021), history of dyslipidemia (OR: 0.42, 95% CI: 0.19\u20130.93, p = 0.032), BMI (OR: 0.90, 95% CI: 0.82\u20130.99, p = 0.022), hemoglobin (OR: 1.29, 95% CI: 1.04\u20131.61, p = 0.020), white blood cell count (OR: 0.81, 95% CI: 0.66\u20130.98, p = 0.033), CR exercise sessions (OR: 1.10, 95% CI: 1.04\u20131.15, p &lt; 0.001), and pre-HTx VO2peak (OR: 1.17, 95% CI: 1.07\u20131.29, p = 0.001) were significant predictors. Multivariate analysis showed CR exercise sessions (OR: 1.10, 95% CI: 1.03\u20131.16, p = 0.002), and pre-HTx VO2peak (OR: 1.16, 95% CI: 1.04\u20131.30, p = 0.007) were independently predictive of higher post-HTx VO2peak. Pre-HTx VO2peak and CR exercise sessions are predictive of a greater VO2peak following HTx. These data highlight the importance of CR exercise session attendance and pre-HTx fitness in predicting VO2peak post-HTx.<\/jats:p>","DOI":"10.3390\/jcm8010119","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T03:08:22Z","timestamp":1548126502000},"page":"119","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical and Rehabilitative Predictors of Peak Oxygen Uptake Following Cardiac Transplantation"],"prefix":"10.3390","volume":"8","author":[{"given":"Katelyn E.","family":"Uithoven","sequence":"first","affiliation":[{"name":"School of Kinesiology, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3687-6261","authenticated-orcid":false,"given":"Joshua R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8705-0462","authenticated-orcid":false,"given":"Jose R.","family":"Medina-Inojosa","sequence":"additional","affiliation":[{"name":"Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray W.","family":"Squires","sequence":"additional","affiliation":[{"name":"Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0576-3229","authenticated-orcid":false,"given":"Erik H.","family":"Van Iterson","sequence":"additional","affiliation":[{"name":"Section of Preventive Cardiology and Rehabilitation, Cleveland Clinic, Cleveland, OH 44195, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas P.","family":"Olson","sequence":"additional","affiliation":[{"name":"Division of Preventive Cardiology, Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1161\/01.CIR.83.3.778","article-title":"Value of peak exercise oxygen consumption for optimal timing of cardiac transplantation in ambulatory patients with heart failure","volume":"83","author":"Mancini","year":"1991","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.jacc.2005.11.089","article-title":"Effects of gender on peak oxygen consumption and the timing of cardiac transplantation","volume":"47","author":"Elmariah","year":"2006","journal-title":"J. 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