{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T11:57:48Z","timestamp":1776859068637,"version":"3.51.2"},"reference-count":104,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The permanent interaction between bone tissue and the immune system shows us the complex biology of the tissue in which we insert oral implants. At the same time, new knowledge in relation to the interaction of materials and the host, reveals to us the true nature of osseointegration. So, to achieve clinical success or perhaps most importantly, to understand why we sometimes fail, the study of oral implantology should consider the following advice equally important: a correct clinical protocol, the study of the immunomodulatory capacity of the device and the osteoimmunobiology of the host. Although osseointegration may seem adequate from the clinical point of view, a deeper vision shows us that a Foreign Body Equilibrium could be susceptible to environmental conditions. This is why maintaining this cellular balance should become our therapeutic target and, more specifically, the understanding of the main cell involved, the macrophage. The advent of new information, the development of new implant surfaces and the introduction of new therapeutic proposals such as therapeutic mechanotransduction, will allow us to maintain a healthy host-implant relationship long-term.<\/jats:p>","DOI":"10.3390\/jcm8020139","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T11:30:00Z","timestamp":1548415800000},"page":"139","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Coupling between Osseointegration and Mechanotransduction to Maintain Foreign Body Equilibrium in the Long-Term: A Comprehensive Overview"],"prefix":"10.3390","volume":"8","author":[{"given":"Luis","family":"Amengual-Pe\u00f1afiel","sequence":"first","affiliation":[{"name":"Dental Implantology Unit, Hospital Leonardo Guzm\u00e1n, Antofagasta 1240835, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Bra\u00f1es-Aroca","sequence":"additional","affiliation":[{"name":"Faculty of Sciences, Universidad de Chile, Santiago 7800003, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Marchesani-Carrasco","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Marchesani, Concepci\u00f3n 4070566, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Costanza","family":"Jara-Sep\u00falveda","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Marchesani, Concepci\u00f3n 4070566, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leopoldo","family":"Parada-Pozas","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Center, Hospital Cl\u00ednico de Vi\u00f1a del Mar, Vi\u00f1a del Mar 2520626, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Cartes-Vel\u00e1squez","sequence":"additional","affiliation":[{"name":"School of Dentistry, Universidad Andres Bello, Concepci\u00f3n 4300866, Chile"},{"name":"Institute of Biomedical Sciences, Universidad Aut\u00f3noma de Chile, Temuco 4810101, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.coms.2015.01.004","article-title":"Current concepts for the biological basis of dental implants: Foreign body equilibrium and osseointegration dynamics","volume":"27","author":"Trindade","year":"2015","journal-title":"Oral Maxillofac. 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