{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:51:24Z","timestamp":1767988284496,"version":"3.49.0"},"reference-count":18,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T00:00:00Z","timestamp":1549584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Type 1 Gaucher disease is a rare genetic lysosomal disorder due to acid betaglucosidase deficiency. The main features are thrombocytopenia, anemia, hepatosplenomegaly and complex skeletal disease. Complications include pulmonary hypertension, cirrhosis and splenic infarction; comorbidities, such as autoimmune phenomena, B-cell malignancies and Parkinson disease also occur. Visceral aneurysms have been only rarely noted in Gaucher disease. We report the retrospective data from patients with Gaucher disease type 1 and splenic arterial aneurysm. We describe the different outcomes of a giant splenic arterial aneurysm in five patients with type 1 Gaucher disease and discuss the main possible pathophysiological explanations. Aneurysms of the splenic artery are rare in Gaucher disease but are probably greatly under-reported.<\/jats:p>","DOI":"10.3390\/jcm8020219","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T03:26:01Z","timestamp":1549855561000},"page":"219","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Splenic Artery Aneurysms, a Rare Complication of Type 1 Gaucher Disease: Report of Five Cases"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9940-4686","authenticated-orcid":false,"given":"Christine","family":"Serratrice","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Rehabilitation, University Hospital of Geneva, H\u00f4pital des Trois Ch\u00eane, 1226 Thonex, Switzerland"},{"name":"Division of Internal Medicine of the Aged, University Hospital of Geneva, 1205 Geneva, Switzerland"},{"name":"Department of Internal Medicine, Saint Joseph Hospital, 13008 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy M.","family":"Cox","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK"},{"name":"Lysosomal Disorders Unit, Addenbrooke\u2019s Hospital, Cambridge CB2 0QQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Leguy-Seguin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, University Hospital of Dijon, 21000 Dijon, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Morris","sequence":"additional","affiliation":[{"name":"Lysosomal Disorders Unit, Addenbrooke\u2019s Hospital, Cambridge CB2 0QQ, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karima","family":"Yousfi","sequence":"additional","affiliation":[{"name":"Reference Centre of Lysosomal Diseases, University Hospital Beaujon, 92110 Clichy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Monnet","sequence":"additional","affiliation":[{"name":"Department of Radiology, Saint Joseph Hospital, 13008 Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie","family":"Sibert","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Beaujon, 92110 Clichy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wassim","family":"Allaham","sequence":"additional","affiliation":[{"name":"Department of Radiology, University Hospital Beaujon, 92110 Clichy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Belmatoug","sequence":"additional","affiliation":[{"name":"Reference Centre of Lysosomal Diseases, University Hospital Beaujon, 92110 Clichy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1172\/JCI105417","article-title":"Demonstration of a deficiency of glucocerebroside-cleaving enzyme in Gaucher\u2019s disease","volume":"45","author":"Brady","year":"1966","journal-title":"J. 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