{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:26:04Z","timestamp":1790706364558,"version":"4.1.0"},"reference-count":184,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T00:00:00Z","timestamp":1550188800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"a Grant-in-Aid for Scientific Research (B) from the Ministry of Education, Culture, Sports, Science and Technology of Japan","award":["26293294, S.K."],"award-info":[{"award-number":["26293294, S.K."]}]},{"name":"a Challenging Research (Exploratory) from the Ministry of Education, Culture, Sports, Science and Technology of Japan","award":["17K19692, N.S."],"award-info":[{"award-number":["17K19692, N.S."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Type 1 diabetes mellitus (T1DM) is caused by the autoimmune targeting of pancreatic \u03b2-cells, and, in the advanced stage, severe hypoinsulinemia due to islet destruction. In patients with T1DM, continuous exogenous insulin therapy cannot be avoided. However, an insufficient dose of insulin easily induces extreme hyperglycemia or diabetic ketoacidosis, and intensive insulin therapy may cause hypoglycemic symptoms including hypoglycemic shock. While these insulin therapies are efficacious in most patients, some additional therapies are warranted to support the control of blood glucose levels and reduce the risk of hypoglycemia in patients who respond poorly despite receiving appropriate treatment. There has been a recent gain in the popularity of cellular therapies using mesenchymal stromal cells (MSCs) in various clinical fields, owing to their multipotentiality, capacity for self-renewal, and regenerative and immunomodulatory potential. In particular, adipose tissue-derived MSCs (ADMSCs) have become a focus in the clinical setting due to the abundance and easy isolation of these cells. In this review, we outline the possible therapeutic benefits of ADMSC for the treatment of T1DM.<\/jats:p>","DOI":"10.3390\/jcm8020249","type":"journal-article","created":{"date-parts":[[2019,2,17]],"date-time":"2019-02-17T22:11:50Z","timestamp":1550441510000},"page":"249","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Regenerative and Transplantation Medicine: Cellular Therapy Using Adipose Tissue-Derived Mesenchymal Stromal Cells for Type 1 Diabetes Mellitus"],"prefix":"10.3390","volume":"8","author":[{"given":"Hiroyuki","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Regenerative Medicine &amp; Transplantation, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan"},{"name":"Center for Regenerative Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan"},{"name":"Department of Gastroenterological Surgery, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3495-4270","authenticated-orcid":false,"given":"Naoaki","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine &amp; Transplantation, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan"},{"name":"Center for Regenerative Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6559-5947","authenticated-orcid":false,"given":"Gumpei","family":"Yoshimatsu","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine &amp; Transplantation, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan"},{"name":"Center for Regenerative Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suguru","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterological Surgery, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9571-342X","authenticated-orcid":false,"given":"Shohta","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Regenerative Medicine &amp; Transplantation, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan"},{"name":"Center for Regenerative Medicine, Fukuoka University Hospital, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,2,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.diabres.2017.03.024","article-title":"IDF Diabetes Atlas: Global estimates for the prevalence of diabetes for 2015 and 2040","volume":"128","author":"Ogurtsova","year":"2017","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_2","first-page":"489","article-title":"Review and case report of idiopathic lower extremity compartment syndrome and its treatment in diabetic patients","volume":"26","author":"Pamoukian","year":"2000","journal-title":"Diabetes Metab."},{"key":"ref_3","first-page":"341","article-title":"Chronic diabetic complications: The body\u2019s adaptive response to hyperglycemia gone awry?","volume":"117","author":"Chan","year":"2006","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1056\/NEJM198605223142106","article-title":"Type I diabetes mellitus: A chronic autoimmune disease","volume":"314","author":"Eisenbarth","year":"1986","journal-title":"N. Engl. J. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0140-6736(06)68341-4","article-title":"Type 1 diabetes","volume":"367","author":"Daneman","year":"2006","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"328","DOI":"10.5966\/sctm.2012-0116","article-title":"Stem cell therapy to cure type 1 diabetes: From hype to hope","volume":"2","author":"Chhabra","year":"2013","journal-title":"Stem Cells Transl. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2165\/00024677-200302020-00003","article-title":"Diabetic ketoacidosis: Risk factors and management strategies","volume":"2","author":"Umpierrez","year":"2003","journal-title":"Treat. Endocrino.l"},{"key":"ref_8","first-page":"CD005103","article-title":"Continuous subcutaneous insulin infusion (CSII) versus multiple insulin injections for type 1 diabetes mellitus","volume":"1","author":"Misso","year":"2010","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/S0140-6736(18)31947-0","article-title":"Closed-loop insulin delivery in suboptimally controlled type 1 diabetes: A multicentre, 12-week randomised trial","volume":"392","author":"Tauschmann","year":"2018","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41574-018-0044-y","article-title":"Technology in the management of type 1 diabetes mellitus\u2014Current status and future prospects","volume":"14","author":"Tauschmann","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3288","DOI":"10.2337\/diacare.26.12.3288","article-title":"Benefits and risks of solitary islet transplantation for type 1 diabetes using steroid-sparing immunosuppression: The National Institutes of Health experience","volume":"26","author":"Hirshberg","year":"2003","journal-title":"Diabetes Care"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","article-title":"Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen","volume":"343","author":"Shapiro","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1210\/jc.2016-1649","article-title":"Long-Term Improvement in Glucose Control and Counterregulation by Islet Transplantation for Type 1 Diabetes","volume":"101","author":"Rickels","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Sakata, N., Yoshimatsu, G., and Kodama, S. (2018). The Spleen as an Optimal Site for Islet Transplantation and a Source of Mesenchymal Stem Cells. Int. J. Mol. Sci., 19.","DOI":"10.20944\/preprints201802.0101.v2"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jamcollsurg.2011.12.040","article-title":"Total pancreatectomy and islet autotransplantation for chronic pancreatitis","volume":"214","author":"Sutherland","year":"2012","journal-title":"J. Am. Coll. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nri1332","article-title":"Clinical islet transplantation: Advances and immunological challenges","volume":"4","author":"Ricordi","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.2337\/diabetes.54.7.2060","article-title":"Five-year follow-up after clinical islet transplantation","volume":"54","author":"Ryan","year":"2005","journal-title":"Diabetes"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.2337\/dc12-0063","article-title":"Improvement in outcomes of clinical islet transplantation: 1999\u20132010","volume":"35","author":"Barton","year":"2012","journal-title":"Diabetes Care"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5150","DOI":"10.3748\/wjg.v17.i47.5150","article-title":"Utility of co-transplanting mesenchymal stem cells in islet transplantation","volume":"17","author":"Sakata","year":"2011","journal-title":"World J. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1021\/mp3005148","article-title":"Mesenchymal stem cell-based therapy","volume":"10","author":"Mundra","year":"2013","journal-title":"Mol. Pharm."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.287.5457.1427","article-title":"Out of Eden: Stem cells and their niches","volume":"287","author":"Watt","year":"2000","journal-title":"Science"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1089\/ten.tea.2013.0123","article-title":"Differential response of human adipose tissue-derived mesenchymal stem cells, dermal fibroblasts, and keratinocytes to burn wound exudates: Potential role of skin-specific chemokine CCL27","volume":"20","author":"Kroeze","year":"2014","journal-title":"Tissue Eng. Part. A"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s13287-017-0638-7","article-title":"Epigenetic reprogramming converts human Wharton\u2019s jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators","volume":"8","author":"Bhuvanalakshmi","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"405101","DOI":"10.1088\/0957-4484\/25\/40\/405101","article-title":"Stem cell-mediated delivery of SPIO-loaded gold nanoparticles for the theranosis of liver injury and hepatocellular carcinoma","volume":"25","author":"Zhao","year":"2014","journal-title":"Nanotechnology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.3892\/mmr.2014.2502","article-title":"Effect of bone marrow stromal cell transplantation on neurologic function and expression of VEGF in rats with focal cerebral ischemia","volume":"10","author":"Li","year":"2014","journal-title":"Mol. Med. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.pharmthera.2014.02.013","article-title":"Mesenchymal stem\/stromal cells as a pharmacological and therapeutic approach to accelerate angiogenesis","volume":"143","author":"Bronckaers","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"717","DOI":"10.17219\/acem\/68386","article-title":"The expression of marker genes during the differentiation of mesenchymal stromal cells","volume":"27","author":"Zolocinska","year":"2018","journal-title":"Adv. Clin. Exp. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1182\/blood-2004-09-3696","article-title":"Bone marrow mesenchymal stem cells induce division arrest anergy of activated T cells","volume":"105","author":"Glennie","year":"2005","journal-title":"Blood"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1182\/blood-2002-07-2104","article-title":"Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide","volume":"101","author":"Krampera","year":"2003","journal-title":"Blood"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"881","DOI":"10.3324\/haematol.11240","article-title":"Generation of CD4+ or CD8+ regulatory T cells upon mesenchymal stem cell-lymphocyte interaction","volume":"92","author":"Prevosto","year":"2007","journal-title":"Haematologica"},{"key":"ref_31","first-page":"393","article-title":"The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells","volume":"3","author":"Friedenstein","year":"1970","journal-title":"Cell Tissue Kinet."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1634\/stemcells.2007-0197","article-title":"Concise review: Mesenchymal stem cells: Their phenotype, differentiation capacity, immunological features, and potential for homing","volume":"25","author":"Chamberlain","year":"2007","journal-title":"Stem Cells"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.cell.2007.04.028","article-title":"Neuroepithelial cells supply an initial transient wave of MSC differentiation","volume":"129","author":"Takashima","year":"2007","journal-title":"Cell"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.bbrc.2009.01.031","article-title":"Development of mesenchymal stem cells partially originate from the neural crest","volume":"379","author":"Morikawa","year":"2009","journal-title":"Biochem. Biophys Res. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"6726185","DOI":"10.1155\/2018\/6726185","article-title":"Current Strategies to Generate Human Mesenchymal Stem Cells In Vitro","volume":"2018","author":"Steens","year":"2018","journal-title":"Stem Cells Int."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"key":"ref_37","first-page":"1017","article-title":"Isolation and characterization of human umbilical cord mesenchymal stem cells with hematopoiesis-supportive function and other potentials","volume":"91","author":"Lu","year":"2006","journal-title":"Haematologica"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1126\/science.1088949","article-title":"Islet regeneration during the reversal of autoimmune diabetes in NOD mice","volume":"302","author":"Kodama","year":"2003","journal-title":"Science"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/labinvest.3700377","article-title":"Expansion of mesenchymal stem cells from human pancreatic ductal epithelium","volume":"86","author":"Seeberger","year":"2006","journal-title":"Lab. Invest."},{"key":"ref_40","first-page":"267","article-title":"Fibroblast precursors in normal and irradiated mouse hematopoietic organs","volume":"4","author":"Friedenstein","year":"1976","journal-title":"Exp. Hematol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"8973613","DOI":"10.1155\/2018\/8973613","article-title":"Dental Mesenchymal Stem\/Stromal Cells and Their Exosomes","volume":"2018","author":"Stanko","year":"2018","journal-title":"Stem Cells Int."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0014-4827(03)00376-8","article-title":"Growth and differentiation potential of main- and side-population cells derived from murine skeletal muscle","volume":"291","author":"Tamaki","year":"2003","journal-title":"Exp. Cell Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/sj.cr.7290323","article-title":"Mesenchymal stem cells derived from human placenta suppress allogeneic umbilical cord blood lymphocyte proliferation","volume":"15","author":"Li","year":"2005","journal-title":"Cell Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1530\/EC-18-0067","article-title":"Isolation of a multipotent mesenchymal stem cell-like population from human adrenal cortex","volume":"7","author":"Gan","year":"2018","journal-title":"Endocr. Connect."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1684\/ejd.2017.2988","article-title":"Properties of skin stem cells and their potential clinical applications in modern dermatology","volume":"27","author":"Niezgoda","year":"2017","journal-title":"Eur. J. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.1091\/mbc.e02-02-0105","article-title":"Human adipose tissue is a source of multipotent stem cells","volume":"13","author":"Zuk","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.15252\/embj.201696206","article-title":"Adipose tissue: Between the extremes","volume":"36","author":"Vegiopoulos","year":"2017","journal-title":"EMBO J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1161\/01.RES.0000265074.83288.09","article-title":"Adipose-derived stem cells for regenerative medicine","volume":"100","author":"Gimble","year":"2007","journal-title":"Circ. Res."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Bateman, M.E., Strong, A.L., Gimble, J.M., and Bunnell, B.A. (2018). Concise Review: Using Fat to Fight Disease: A Systematic Review of Nonhomologous Adipose-Derived Stromal\/Stem Cell Therapies. Stem Cells.","DOI":"10.1002\/stem.2847"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"812693","DOI":"10.1155\/2012\/812693","article-title":"Adipose-derived mesenchymal stromal\/stem cells: Tissue localization, characterization, and heterogeneity","volume":"2012","author":"Baer","year":"2012","journal-title":"Stem Cells Int."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1089\/107632701300062859","article-title":"Multilineage cells from human adipose tissue: Implications for cell-based therapies","volume":"7","author":"Zuk","year":"2001","journal-title":"Tissue Eng."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.jcyt.2013.02.006","article-title":"Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal\/stem cells: A joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT)","volume":"15","author":"Bourin","year":"2013","journal-title":"Cytotherapy"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s13287-018-0914-1","article-title":"Adipose-derived and bone marrow mesenchymal stem cells: A donor-matched comparison","volume":"9","author":"Fristad","year":"2018","journal-title":"Stem Cell Res. Ther."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tice.2010.04.003","article-title":"Isolation, identification and multipotential differentiation of mouse adipose tissue-derived stem cells","volume":"42","author":"Taha","year":"2010","journal-title":"Tissue Cell"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4161\/cc.11.2.18858","article-title":"Bone marrow- and subcutaneous adipose tissue-derived mesenchymal stem cells: Differences and similarities","volume":"11","author":"Dmitrieva","year":"2012","journal-title":"Cell Cycle"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1365-2141.2005.05409.x","article-title":"Immunomodulatory effect of human adipose tissue-derived adult stem cells: Comparison with bone marrow mesenchymal stem cells","volume":"129","author":"Puissant","year":"2005","journal-title":"Br. J. Haematol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.jcyt.2016.07.006","article-title":"Comparative analysis of the immunomodulatory capacities of human bone marrow- and adipose tissue-derived mesenchymal stromal cells from the same donor","volume":"18","author":"Valencia","year":"2016","journal-title":"Cytotherapy"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1002\/eji.200425405","article-title":"Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway","volume":"35","author":"Augello","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.2337\/db11-0844","article-title":"Immune regulatory properties of allogeneic adipose-derived mesenchymal stem cells in the treatment of experimental autoimmune diabetes","volume":"61","author":"Bassi","year":"2012","journal-title":"Diabetes"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.imlet.2009.07.010","article-title":"Adipose tissue-derived mesenchymal stem cells are more potent suppressors of dendritic cells differentiation compared to bone marrow-derived mesenchymal stem cells","volume":"126","author":"Bochev","year":"2009","journal-title":"Immunol. Lett."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1634\/stemcells.2008-0034","article-title":"IFATS collection: In vivo therapeutic potential of human adipose tissue mesenchymal stem cells after transplantation into mice with liver injury","volume":"26","author":"Banas","year":"2008","journal-title":"Stem Cells"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1653254","DOI":"10.1155\/2017\/1653254","article-title":"Trophic Activity and Phenotype of Adipose Tissue-Derived Mesenchymal Stem Cells as a Background of Their Regenerative Potential","volume":"2017","author":"Kocan","year":"2017","journal-title":"Stem Cells Int."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"9581350","DOI":"10.1155\/2016\/9581350","article-title":"Comparison of Immunomodulation Properties of Porcine Mesenchymal Stromal\/Stem Cells Derived from the Bone Marrow, Adipose Tissue, and Dermal Skin Tissue","volume":"2016","author":"Ock","year":"2016","journal-title":"Stem Cells Int."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13287-015-0066-5","article-title":"Comparative analysis of human mesenchymal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy","volume":"6","author":"Li","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3892\/ijmm.2012.1199","article-title":"Direct comparison of the potency of human mesenchymal stem cells derived from amnion tissue, bone marrow and adipose tissue at inducing dermal fibroblast responses to cutaneous wounds","volume":"31","author":"Liu","year":"2013","journal-title":"Int. J. Mol. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/scrt391","article-title":"Comparison of human adult stem cells from adipose tissue and bone marrow in the treatment of experimental autoimmune encephalomyelitis","volume":"5","author":"Semon","year":"2014","journal-title":"Stem Cell Res. Ther."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jcyt.2012.11.015","article-title":"Comparison of mesenchymal stromal cells from human bone marrow and adipose tissue for the treatment of spinal cord injury","volume":"15","author":"Zhou","year":"2013","journal-title":"Cytotherapy"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3109\/14653249.2010.549122","article-title":"Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy","volume":"13","author":"Ikegame","year":"2011","journal-title":"Cytotherapy"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1568-9972(02)00033-2","article-title":"Hematopoietic stem cell therapy for type 1 diabetes: Induction of tolerance and islet cell neogenesis","volume":"1","author":"Burt","year":"2002","journal-title":"Autoimmun. Rev."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nbt841","article-title":"Bone marrow-derived stem cells initiate pancreatic regeneration","volume":"21","author":"Hess","year":"2003","journal-title":"Nat. Biotechnol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1210\/en.2002-220350","article-title":"A new cell secreting insulin","volume":"144","author":"Roy","year":"2003","journal-title":"Endocrinology"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.biocel.2013.11.006","article-title":"Making surrogate beta-cells from mesenchymal stromal cells: Perspectives and future endeavors","volume":"46","author":"Bhonde","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/TP.0000000000001937","article-title":"beta Cell Replacement Therapy: The Next 10 Years","volume":"102","author":"Schuetz","year":"2018","journal-title":"Transplantation"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.bbrc.2006.01.072","article-title":"Human adipose tissue-derived mesenchymal stem cells differentiate into insulin, somatostatin, and glucagon expressing cells","volume":"341","author":"Timper","year":"2006","journal-title":"Biochem. Biophys Res. Commun."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10047-009-0455-6","article-title":"Transdifferentiation of human adipose tissue-derived stromal cells into insulin-producing clusters","volume":"12","author":"Okura","year":"2009","journal-title":"J. Artif. Organs"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1002\/stem.127","article-title":"Insulin-secreting cells from human eyelid-derived stem cells alleviate type I diabetes in immunocompetent mice","volume":"27","author":"Kang","year":"2009","journal-title":"Stem Cells"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1387\/ijdb.092953hk","article-title":"Pdx1-transfected adipose tissue-derived stem cells differentiate into insulin-producing cells in vivo and reduce hyperglycemia in diabetic mice","volume":"54","author":"Kajiyama","year":"2010","journal-title":"Int. J. Dev. Biol."},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Chandra, V., Swetha, G., Muthyala, S., Jaiswal, A.K., Bellare, J.R., Nair, P.D., and Bhonde, R.R. (2011). Islet-like cell aggregates generated from human adipose tissue derived stem cells ameliorate experimental diabetes in mice. PloS ONE, 6.","DOI":"10.1371\/journal.pone.0020615"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.jbiosc.2012.02.007","article-title":"Glucose-stimulated insulin secretion of various mesenchymal stem cells after insulin-producing cell differentiation","volume":"113","author":"Kim","year":"2012","journal-title":"J. Biosci. Bioeng."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3727\/096368912X657215","article-title":"Differentiation of human adipose tissue-derived stem cells into aggregates of insulin-producing cells through the overexpression of pancreatic and duodenal homeobox gene-1","volume":"22","author":"Lee","year":"2013","journal-title":"Cell Transplant."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.bbrc.2013.10.059","article-title":"Transplantation of insulin-secreting cells differentiated from human adipose tissue-derived stem cells into type 2 diabetes mice","volume":"443","author":"Nam","year":"2014","journal-title":"Biochem. Biophys Res. Commun."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"936","DOI":"10.3892\/ijmm.2017.2914","article-title":"Transplantation of betatrophin-expressing adipose-derived mesenchymal stem cells induces beta-cell proliferation in diabetic mice","volume":"39","author":"Sun","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.gene.2018.02.008","article-title":"Role of adipose tissue derived stem cells differentiated into insulin producing cells in the treatment of type I diabetes mellitus","volume":"654","author":"Amer","year":"2018","journal-title":"Gene"},{"key":"ref_84","first-page":"310","article-title":"In Vivo Differentiation of Mesenchymal Stem Cells into Insulin Producing Cells on Electrospun Poly-L-Lactide Acid Scaffolds Coated with Matricaria chamomilla L. Oil","volume":"18","author":"Fazili","year":"2016","journal-title":"Cell J."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.jcyt.2017.05.003","article-title":"Sonic hedgehog pathway suppression and reactivation accelerates differentiation of rat adipose-derived mesenchymal stromal cells toward insulin-producing cells","volume":"19","author":"Dayer","year":"2017","journal-title":"Cytotherapy"},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.3389\/fphar.2018.01114","article-title":"Regulatory Mechanisms of the Wnt\/beta-Catenin Pathway in Diabetic Cutaneous Ulcers","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2013.09.105","article-title":"MiR-375, a microRNA related to diabetes","volume":"533","author":"Li","year":"2014","journal-title":"Gene"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/978-90-481-3271-3_17","article-title":"Wnt signaling in pancreatic islets","volume":"654","author":"Liu","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_89","first-page":"2501578","article-title":"Effect of Wnt Signaling on the Differentiation of Islet beta-Cells from Adipose-Derived Stem Cells","volume":"2017","author":"Wang","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s12038-018-9796-8","article-title":"In vitro preconditioning of insulin-producing cells with growth factors improves their survival and ability to release insulin","volume":"43","author":"Anjum","year":"2018","journal-title":"J. Biosci."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.biologicals.2016.12.004","article-title":"Insulin producing cells generation by overexpression of miR-375 in adipose-derived mesenchymal stem cells from diabetic patients","volume":"46","author":"Piran","year":"2017","journal-title":"Biologicals"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature03076","article-title":"A pancreatic islet-specific microRNA regulates insulin secretion","volume":"432","author":"Poy","year":"2004","journal-title":"Nature"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1073\/pnas.0810550106","article-title":"miR-375 maintains normal pancreatic alpha- and beta-cell mass","volume":"106","author":"Poy","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"3854232","DOI":"10.1155\/2017\/3854232","article-title":"From Human Mesenchymal Stem Cells to Insulin-Producing Cells: Comparison between Bone Marrow- and Adipose Tissue-Derived Cells","volume":"2017","author":"Gabr","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.jcyt.2013.01.005","article-title":"Adipose tissue-derived mesenchymal stromal cells efficiently differentiate into insulin-producing cells in pancreatic islet microenvironment both in vitro and in vivo","volume":"15","author":"Karaoz","year":"2013","journal-title":"Cytotherapy"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1089\/scd.2016.0022","article-title":"Mesenchymal Stem Cells Derived from Human Bone Marrow and Adipose Tissue Maintain Their Immunosuppressive Properties After Chondrogenic Differentiation: Role of HLA-G","volume":"25","author":"Du","year":"2016","journal-title":"Stem Cells Dev."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1002\/stem.1676","article-title":"Human adipose-derived stromal\/stem cells protect against STZ-induced hyperglycemia: Analysis of hASC-derived paracrine effectors","volume":"32","author":"Kono","year":"2014","journal-title":"Stem Cells"},{"key":"ref_98","doi-asserted-by":"crossref","unstructured":"Navaei-Nigjeh, M., Moloudizargari, M., Baeeri, M., Gholami, M., Lotfibakhshaiesh, N., Soleimani, M., Vasheghani-Farahani, E., Ai, J., and Abdollahi, M. (2018). Reduction of marginal mass required for successful islet transplantation in a diabetic rat model using adipose tissue-derived mesenchymal stromal cells. Cytotherapy.","DOI":"10.1016\/j.jcyt.2018.06.001"},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Dang, L.T., Bui, A.N., Le-Thanh Nguyen, C., Truong, N.C., Bui, A.T., Kim, N.P., Truong, K.D., and Van Pham, P. (2018). Intravenous Infusion of Human Adipose Tissue-Derived Mesenchymal Stem Cells to Treat Type 1 Diabetic Mellitus in Mice: An Evaluation of Grafted Cell Doses. Adv. Exp. Med. Biol.","DOI":"10.1007\/5584_2017_127"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"960","DOI":"10.2337\/db06-1254","article-title":"Ischemic vascular damage can be repaired by healthy, but not diabetic, endothelial progenitor cells","volume":"56","author":"Caballero","year":"2007","journal-title":"Diabetes"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.jaut.2009.01.003","article-title":"Marginal mass islet transplantation with autologous mesenchymal stem cells promotes long-term islet allograft survival and sustained normoglycemia","volume":"32","author":"Solari","year":"2009","journal-title":"J. Autoimmun."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.transproceed.2008.11.015","article-title":"Bone marrow-derived mesenchymal stem cells improve islet graft function in diabetic rats","volume":"41","author":"Figliuzzi","year":"2009","journal-title":"Transplant. Proc."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1097\/TP.0b013e3181db09c4","article-title":"Mesenchymal stem cell and islet co-transplantation promotes graft revascularization and function","volume":"89","author":"Ito","year":"2010","journal-title":"Transplantation"},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.2337\/db10-0136","article-title":"Mesenchymal stem cells enhance allogeneic islet engraftment in nonhuman primates","volume":"59","author":"Berman","year":"2010","journal-title":"Diabetes"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1097\/TP.0b013e3181ffba31","article-title":"Combined transplantation of pancreatic islets and adipose tissue-derived stem cells enhances the survival and insulin function of islet grafts in diabetic mice","volume":"90","author":"Ohmura","year":"2010","journal-title":"Transplantation"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"e00632","DOI":"10.1016\/j.heliyon.2018.e00632","article-title":"Expansion of transplanted islets in mice by co-transplantation with adipose tissue-derived mesenchymal stem cells","volume":"4","author":"Tanaka","year":"2018","journal-title":"Heliyon"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.imlet.2017.05.006","article-title":"Immunomodulatory and protective effects of adipose tissue-derived mesenchymal stem cells in an allograft islet composite transplantation for experimental autoimmune type 1 diabetes","volume":"188","author":"Niknam","year":"2017","journal-title":"Immunol. Lett."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.3727\/096368912X637046","article-title":"Mesenchymal stem cells and islet cotransplantation in diabetic rats: Improved islet graft revascularization and function by human adipose tissue-derived stem cells preconditioned with natural molecules","volume":"21","author":"Cavallari","year":"2012","journal-title":"Cell Transplant."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"7247","DOI":"10.1016\/j.biomaterials.2013.06.018","article-title":"Mutual effect of subcutaneously transplanted human adipose-derived stem cells and pancreatic islets within fibrin gel","volume":"34","author":"Bhang","year":"2013","journal-title":"Biomaterials"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1042\/CS20171251","article-title":"Mesenchymal stromal cells improve human islet function through released products and extracellular matrix","volume":"131","author":"Arzouni","year":"2017","journal-title":"Clin. Sci. (Lond)"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1097\/TP.0b013e3181ef8a63","article-title":"Cooperative signaling for angiogenesis and neovascularization by VEGF and HGF following islet transplantation","volume":"90","author":"Golocheikine","year":"2010","journal-title":"Transplantation"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"878535","DOI":"10.1155\/2015\/878535","article-title":"Adipose tissue-derived mesenchymal stem cells exert in vitro immunomodulatory and beta cell protective functions in streptozotocin-induced diabetic mice model","volume":"2015","author":"Rahavi","year":"2015","journal-title":"J. Diabetes Res."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s13287-017-0627-x","article-title":"Adipose stem cells from chronic pancreatitis patients improve mouse and human islet survival and function","volume":"8","author":"Song","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.jss.2013.10.031","article-title":"Trophic effect of adipose tissue-derived stem cells on porcine islet cells","volume":"187","author":"Yamada","year":"2014","journal-title":"J. Surg. Res."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12929-018-0429-1","article-title":"Regenerative abilities of mesenchymal stem cells through mitochondrial transfer","volume":"25","author":"Paliwal","year":"2018","journal-title":"J. Biomed. Sci."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3727\/215517914X680047","article-title":"Preculturing Islets With Adipose-Derived Mesenchymal Stromal Cells Is an Effective Strategy for Improving Transplantation Efficiency at the Clinically Preferred Intraportal Site","volume":"7","author":"Rackham","year":"2014","journal-title":"Cell Med."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1016\/j.transproceed.2017.11.003","article-title":"Hypoxia-Induced Damage in Human Islets Is Reduced With the Use of Mesenchymal Stem Cell-Preconditioned Medium","volume":"49","author":"Brandhorst","year":"2017","journal-title":"Transplant. Proc."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3727\/215517917X693401","article-title":"Human Adipose-Derived Mesenchymal Stem Cells Respond to Short-Term Hypoxia by Secreting Factors Beneficial for Human Islets In Vitro and Potentiate Antidiabetic Effect In Vivo","volume":"9","author":"Schive","year":"2017","journal-title":"Cell Med."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"e1445948","DOI":"10.1080\/19382014.2018.1445948","article-title":"An engineered cell sheet composed of human islets and human fibroblast, bone marrow-derived mesenchymal stem cells, or adipose-derived mesenchymal stem cells: An in vitro comparison study","volume":"10","author":"Imamura","year":"2018","journal-title":"Islets"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.yexcr.2005.11.021","article-title":"From heterogeneity to plasticity in adipose tissues: Site-specific differences","volume":"312","author":"Cousin","year":"2006","journal-title":"Exp. Cell Res."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1097\/PRS.0b013e31817d5476","article-title":"Sources of processed lipoaspirate cells: Influence of donor site on cell concentration","volume":"122","author":"Padoin","year":"2008","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s00441-007-0555-7","article-title":"Effect of tissue-harvesting site on yield of stem cells derived from adipose tissue: Implications for cell-based therapies","volume":"332","author":"Jurgens","year":"2008","journal-title":"Cell Tissue Res."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/cbf.3228","article-title":"Gene expression profiles of human subcutaneous and visceral adipose-derived stem cells","volume":"34","author":"Kim","year":"2016","journal-title":"Cell Biochem. Funct."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1089\/ten.tec.2010.0214","article-title":"Nonexpanded mesenchymal stem cells for regenerative medicine: Yield in stromal vascular fraction from adipose tissues","volume":"16","author":"Faustini","year":"2010","journal-title":"Tissue Eng. Part C Methods"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.jcyt.2015.04.004","article-title":"Qualitative and quantitative differences of adipose-derived stromal cells from superficial and deep subcutaneous lipoaspirates: A matter of fat","volume":"17","author":"Cicione","year":"2015","journal-title":"Cytotherapy"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3109\/2000656X.2012.668326","article-title":"Importance of mesenchymal stem cells in autologous fat grafting: A systematic review of existing studies","volume":"46","author":"Oliveri","year":"2012","journal-title":"J. Plast. Surg. Hand. Surg."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13287-017-0483-8","article-title":"Systematic review of patient factors affecting adipose stem cell viability and function: Implications for regenerative therapy","volume":"8","author":"Varghese","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.enzmictec.2016.07.009","article-title":"Matrix metalloproteinases as reagents for cell isolation","volume":"93-94","author":"Knapinska","year":"2016","journal-title":"Enzyme Microb. Technol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.tibtech.2006.01.010","article-title":"Fat tissue: An underappreciated source of stem cells for biotechnology","volume":"24","author":"Fraser","year":"2006","journal-title":"Trends Biotechnol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/14653240310004539","article-title":"Yield of human adipose-derived adult stem cells from liposuction aspirates","volume":"6","author":"Aust","year":"2004","journal-title":"Cytotherapy"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/sj.ijo.0802314","article-title":"Effect of BMI and age on adipose tissue cellularity and differentiation capacity in women","volume":"27","author":"Skurk","year":"2003","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1177\/0963689717721203","article-title":"Impact of Age on Human Adipose Stem Cells for Bone Tissue Engineering","volume":"26","author":"Dufrane","year":"2017","journal-title":"Cell Transplant."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1479-5876-12-8","article-title":"Donor age negatively impacts adipose tissue-derived mesenchymal stem cell expansion and differentiation","volume":"12","author":"Choudhery","year":"2014","journal-title":"J. Transl. Med."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.scr.2011.11.002","article-title":"Aging alters tissue resident mesenchymal stem cell properties","volume":"8","author":"Alt","year":"2012","journal-title":"Stem Cell Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/PRS.0b013e3181954d08","article-title":"Aging and diabetes impair the neovascular potential of adipose-derived stromal cells","volume":"123","author":"Chang","year":"2009","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3109\/14653240903079393","article-title":"Human adipose-derived stem cells isolated from young and elderly women: Their differentiation potential and scaffold interaction during in vitro osteoblastic differentiation","volume":"11","author":"Lopa","year":"2009","journal-title":"Cytotherapy"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1097\/PRS.0000000000004819","article-title":"Abdominoplasty with Circumferential Liposuction: A Review of 1000 Consecutive Cases","volume":"142","author":"Sozer","year":"2018","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Perez, L.M., Bernal, A., de Lucas, B., San Martin, N., Mastrangelo, A., Garcia, A., Barbas, C., and Galvez, B.G. (2015). Altered metabolic and stemness capacity of adipose tissue-derived stem cells from obese mouse and human. PloS ONE, 10.","DOI":"10.1371\/journal.pone.0123397"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.2337\/db08-1770","article-title":"Impaired preadipocyte differentiation in human abdominal obesity: Role of Wnt, tumor necrosis factor-alpha, and inflammation","volume":"58","author":"Isakson","year":"2009","journal-title":"Diabetes"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Oliva-Olivera, W., Moreno-Indias, I., Coin-Araguez, L., Lhamyani, S., Alcaide Torres, J., Fernandez-Veledo, S., Vendrell, J., Camargo, A., El Bekay, R., and Tinahones, F.J. (2017). Different response to hypoxia of adipose-derived multipotent cells from obese subjects with and without metabolic syndrome. PloS ONE, 12.","DOI":"10.1371\/journal.pone.0188324"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/scrt468","article-title":"Diabetes impairs the angiogenic potential of adipose-derived stem cells by selectively depleting cellular subpopulations","volume":"5","author":"Rennert","year":"2014","journal-title":"Stem Cell Res. Ther."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/cbf.3056","article-title":"Characterization of human adipose tissue-derived stromal cells isolated from diabetic patient\u2019s distal limbs with critical ischemia","volume":"32","author":"Koci","year":"2014","journal-title":"Cell Biochem. Funct."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13287-015-0261-4","article-title":"Multipotent mesenchymal stromal cells from patients with newly diagnosed type 1 diabetes mellitus exhibit preserved in vitro and in vivo immunomodulatory properties","volume":"7","author":"Yaochite","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1042\/BC20110033","article-title":"Adipose stem cells originate from perivascular cells","volume":"103","author":"Cai","year":"2011","journal-title":"Biol. Cell"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1161\/CIRCRESAHA.107.159475","article-title":"A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks","volume":"102","author":"Traktuev","year":"2008","journal-title":"Circ. Res."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/bit.22891","article-title":"Recreating the perivascular niche ex vivo using a microfluidic approach","volume":"107","author":"Carrion","year":"2010","journal-title":"Biotechnol. Bioeng."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.stem.2008.08.008","article-title":"All MSCs are pericytes?","volume":"3","author":"Caplan","year":"2008","journal-title":"Cell Stem Cell"},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/ijo.2010.269","article-title":"Native human adipose stromal cells: Localization, morphology and phenotype","volume":"35","author":"Maumus","year":"2011","journal-title":"Int. J. Obes. (Lond)"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3109\/14653249.2010.507330","article-title":"Defining the risks of mesenchymal stromal cell therapy","volume":"12","author":"Prockop","year":"2010","journal-title":"Cytotherapy"},{"key":"ref_150","first-page":"3941","article-title":"Clinical Study on the Medical Value of Combination Therapy Involving Adoptive Immunotherapy and Chemotherapy for Stage IV Colorectal Cancer (COMVI Study)","volume":"37","author":"Yoshida","year":"2017","journal-title":"Anticancer. Res."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/35102167","article-title":"Stem cells, cancer, and cancer stem cells","volume":"414","author":"Reya","year":"2001","journal-title":"Nature"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Wagner, W., Horn, P., Castoldi, M., Diehlmann, A., Bork, S., Saffrich, R., Benes, V., Blake, J., Pfister, S., and Eckstein, V. (2008). Replicative senescence of mesenchymal stem cells: A continuous and organized process. PloS ONE, 3.","DOI":"10.1371\/journal.pone.0002213"},{"key":"ref_153","doi-asserted-by":"crossref","unstructured":"Truong, N.C., Bui, K.H., and Van Pham, P. (2018). Characterization of Senescence of Human Adipose-Derived Stem Cells After Long-Term Expansion. Adv. Exp. Med. Biol.","DOI":"10.1007\/5584_2018_235"},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"11339","DOI":"10.1038\/s41598-018-29477-5","article-title":"Immunophenotyping and transcriptional profiling of in vitro cultured human adipose tissue derived stem cells","volume":"8","author":"Mieczkowska","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jcyt.2012.12.009","article-title":"Chromosomal aberrations and deoxyribonucleic acid single-strand breaks in adipose-derived stem cells during long-term expansion in vitro","volume":"15","author":"Froelich","year":"2013","journal-title":"Cytotherapy"},{"key":"ref_156","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1158\/0008-5472.CAN-04-4194","article-title":"Spontaneous human adult stem cell transformation","volume":"65","author":"Rubio","year":"2005","journal-title":"Cancer Res."},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Holzwarth, C., Vaegler, M., Gieseke, F., Pfister, S.M., Handgretinger, R., Kerst, G., and Muller, I. (2010). Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells. BMC Cell Biol., 11.","DOI":"10.1186\/1471-2121-11-11"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"114e","DOI":"10.1097\/PRS.0000000000001008","article-title":"Lack of activation of telomere maintenance mechanisms in human adipose stromal cells derived from fatty portion of lipoaspirates","volume":"135","author":"Nava","year":"2015","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1089\/scd.2016.0163","article-title":"Adipose-Derived Stem Cells Enhance Cancer Stem Cell Property and Tumor Formation Capacity in Lewis Lung Carcinoma Cells Through an Interleukin-6 Paracrine Circuit","volume":"25","author":"Lu","year":"2016","journal-title":"Stem Cells Dev."},{"key":"ref_160","doi-asserted-by":"crossref","first-page":"34475","DOI":"10.18632\/oncotarget.5922","article-title":"Characterization of adipose-derived stem cells from subcutaneous and visceral adipose tissues and their function in breast cancer cells","volume":"6","author":"Ritter","year":"2015","journal-title":"Oncotarget"},{"key":"ref_161","doi-asserted-by":"crossref","unstructured":"Zhang, Y., Nowicka, A., Solley, T.N., Wei, C., Parikh, A., Court, L., Burks, J.K., Andreeff, M., Woodward, W.A., and Dadbin, A. (2015). Stromal Cells Derived from Visceral and Obese Adipose Tissue Promote Growth of Ovarian Cancers. PloS ONE, 10.","DOI":"10.1371\/journal.pone.0136361"},{"key":"ref_162","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13578-015-0012-3","article-title":"Senescent mesenchymal stem cells promote colorectal cancer cells growth via galectin-3 expression","volume":"5","author":"Li","year":"2015","journal-title":"Cell Biosci."},{"key":"ref_163","doi-asserted-by":"crossref","first-page":"582382","DOI":"10.4061\/2010\/582382","article-title":"Cotransplantation of adipose tissue-derived insulin-secreting mesenchymal stem cells and hematopoietic stem cells: A novel therapy for insulin-dependent diabetes mellitus","volume":"2010","author":"Vanikar","year":"2010","journal-title":"Stem Cells Int."},{"key":"ref_164","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jcyt.2015.03.608","article-title":"Insulin-secreting adipose-derived mesenchymal stromal cells with bone marrow-derived hematopoietic stem cells from autologous and allogenic sources for type 1 diabetes mellitus","volume":"17","author":"Thakkar","year":"2015","journal-title":"Cytotherapy"},{"key":"ref_165","doi-asserted-by":"crossref","unstructured":"Itoh, T., Nishinakamura, H., Kumano, K., Takahashi, H., and Kodama, S. (2017). The Spleen Is an Ideal Site for Inducing Transplanted Islet Graft Expansion in Mice. PloS ONE, 12.","DOI":"10.1371\/journal.pone.0170899"},{"key":"ref_166","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13287-015-0017-1","article-title":"Therapeutic efficacy and biodistribution of allogeneic mesenchymal stem cells delivered by intrasplenic and intrapancreatic routes in streptozotocin-induced diabetic mice","volume":"6","author":"Yaochite","year":"2015","journal-title":"Stem Cell Res. Ther."},{"key":"ref_167","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1186\/s12967-016-0918-5","article-title":"Effects of the intramyocardial implantation of stromal vascular fraction in patients with chronic ischemic cardiomyopathy","volume":"14","author":"Comella","year":"2016","journal-title":"J. Transl. Med."},{"key":"ref_168","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/1479-5876-11-171","article-title":"A prospective, non-randomized, no placebo-controlled, phase Ib clinical trial to study the safety of the adipose derived stromal cells-stromal vascular fraction in idiopathic pulmonary fibrosis","volume":"11","author":"Tzouvelekis","year":"2013","journal-title":"J. Transl. Med."},{"key":"ref_169","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00384-012-1581-9","article-title":"Expanded allogeneic adipose-derived stem cells (eASCs) for the treatment of complex perianal fistula in Crohn\u2019s disease: Results from a multicenter phase I\/IIa clinical trial","volume":"28","author":"Alba","year":"2013","journal-title":"Int. J. Colorectal. Dis."},{"key":"ref_170","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/S0140-6736(16)31203-X","article-title":"Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn\u2019s disease: A phase 3 randomised, double-blind controlled trial","volume":"388","author":"Panes","year":"2016","journal-title":"Lancet"},{"key":"ref_171","doi-asserted-by":"crossref","first-page":"187","DOI":"10.5966\/sctm.2016-0023","article-title":"Comparative Clinical Observation of Arthroscopic Microfracture in the Presence and Absence of a Stromal Vascular Fraction Injection for Osteoarthritis","volume":"6","author":"Nguyen","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"ref_172","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1002\/stem.1634","article-title":"Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: A proof-of-concept clinical trial","volume":"32","author":"Jo","year":"2014","journal-title":"Stem Cells"},{"key":"ref_173","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/SAP.0b013e31823b69fc","article-title":"Adipose-derived stromal cells accelerate wound healing in an organotypic raft culture model","volume":"68","author":"Collawn","year":"2012","journal-title":"Ann. Plast. Surg."},{"key":"ref_174","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.transproceed.2008.03.113","article-title":"Human adipose tissue-derived mesenchymal stem cells combined with hematopoietic stem cell transplantation synthesize insulin","volume":"40","author":"Trivedi","year":"2008","journal-title":"Transplant. Proc."},{"key":"ref_175","doi-asserted-by":"crossref","unstructured":"Trivedi, H.L., Thakkar, U.G., Vanikar, A.V., and Dave, S.D. (2011). Treatment of polyglandular autoimmune syndrome type 3 using co-transplantation of insulin-secreting mesenchymal stem cells and haematopoietic stem cells. BMJ Case Rep., 2011.","DOI":"10.1136\/bcr.07.2011.4436"},{"key":"ref_176","doi-asserted-by":"crossref","unstructured":"Dave, S.D., Vanikar, A.V., and Trivedi, H.L. (2013). Co-infusion of adipose tissue derived mesenchymal stem cell-differentiated insulin-making cells and haematopoietic cells with renal transplantation: A novel therapy for type 1 diabetes mellitus with end-stage renal disease. BMJ Case Rep., 2013.","DOI":"10.1136\/bcr-2013-009901"},{"key":"ref_177","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4103\/2319-4170.122898","article-title":"Co-infusion of autologous adipose tissue derived insulin-secreting mesenchymal stem cells and bone marrow derived hematopoietic stem cells: Viable therapy for type III.C. a diabetes mellitus","volume":"36","author":"Thakkar","year":"2013","journal-title":"Biomed. J."},{"key":"ref_178","unstructured":"(2018, June 20). ClinicalTrials.gov, Available online: https:\/\/clinicaltrials.gov\/ct2\/show\/record\/NCT00703599?term=NCT00703599&rank=1."},{"key":"ref_179","doi-asserted-by":"crossref","unstructured":"Dave, S.D., Trivedi, H.L., Gopal, S.C., and Chandra, T. (2014). Combined therapy of insulin-producing cells and haematopoietic stem cells offers better diabetic control than only haematopoietic stem cells\u2019 infusion for patients with insulin-dependent diabetes. BMJ Case Rep., 2014.","DOI":"10.1136\/bcr-2013-201238"},{"key":"ref_180","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/MPA.0000000000001017","article-title":"A New 2-Step Acceleration Protocol Using a Histone Deacetylase Inhibitor to Generate Insulin-Producing Cells From Adipose-Derived Mesenchymal Stem Cells","volume":"47","author":"Ikemoto","year":"2018","journal-title":"Pancreas"},{"key":"ref_181","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1007\/s10620-017-4578-y","article-title":"Adipose-Derived Stem Cells Ameliorate Experimental Murine Colitis via TSP-1-Dependent Activation of Latent TGF-beta","volume":"62","author":"Takeyama","year":"2017","journal-title":"Dig. Dis. Sci."},{"key":"ref_182","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1161\/01.CIR.0000121425.42966.F1","article-title":"Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells","volume":"109","author":"Rehman","year":"2004","journal-title":"Circulation"},{"key":"ref_183","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13287-016-0350-z","article-title":"Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model","volume":"7","author":"Moscoso","year":"2016","journal-title":"Stem Cell Res. Ther."},{"key":"ref_184","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.biomaterials.2018.08.018","article-title":"Bioengineered stem cell membrane functionalized nanocarriers for therapeutic targeting of severe hindlimb ischemia","volume":"185","author":"Bose","year":"2018","journal-title":"Biomaterials"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/2\/249\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:32:30Z","timestamp":1760185950000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/2\/249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,15]]},"references-count":184,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2]]}},"alternative-id":["jcm8020249"],"URL":"https:\/\/doi.org\/10.3390\/jcm8020249","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,15]]}}}