{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:55:56Z","timestamp":1791618956888,"version":"4.3.4"},"reference-count":32,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,3,2]],"date-time":"2019-03-02T00:00:00Z","timestamp":1551484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Because of its rarity, renal presentation and outcomes of idiopathic nephrotic syndrome (INS; minimal changes disease or focal and segmental glomerulosclerosis) has poorly been described in elderly patients, precluding an individualized therapy procedure. Whether immunosuppressive regimens formerly designed in children and young adults are safe and efficient in elderly remains elusive. In a large multicentric retrospective study that included 116 patients with INS and onset \u2265 60 years of age, we showed that cumulative incidence of renal response was 95% after frontline therapy, with an age-dependent median time-to-response (60 days before 70 years of age at the onset vs. 120 days after; p = 0.03). Cumulative incidence of relapse was 90% at 7 years, with relapse occurring continuously over time. After a median follow-up of 34 months (IQR (12; 57)), 7 patients had died (6%) and 5 reached end-stage renal disease. Complications were highly prevalent: diabetes mellitus (23.3%), hypertension (24.1%), infection requiring hospitalization (21.6%) and acute kidney injury (9.5%). Thus, in older patients with INS and receiving steroids, renal response is delayed and relapse is the rule. Alternative immunosuppressive regimens, including B-cells depleting agents as frontline therapy, should be tested in this subset of patients to improve the mid- to long-term outcomes.<\/jats:p>","DOI":"10.3390\/jcm8030298","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T05:45:36Z","timestamp":1551678336000},"page":"298","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes of Older Patients (\u226560 years) with New-Onset Idiopathic Nephrotic Syndrome Receiving Immunosuppressive Regimen: A Multicentre Study of 116 Patients"],"prefix":"10.3390","volume":"8","author":[{"given":"Elo\u00efse","family":"Colliou","sequence":"first","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie et Transplantation d\u2019Organes, Centre de R\u00e9f\u00e9rence des Maladies R\u00e9nales Rares, Centre Hospitalier Universitaire de Toulouse, 31000 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Karras","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie, H\u00f4pital Europ\u00e9en-Georges Pompidou, Assistance Publique des H\u00f4pitaux de Paris, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Boffa","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie, H\u00f4pital Tenon, Assistance Publique des H\u00f4pitaux de Paris, 75020 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ribes","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie et Transplantation d\u2019Organes, Centre de R\u00e9f\u00e9rence des Maladies R\u00e9nales Rares, Centre Hospitalier Universitaire de Toulouse, 31000 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Garrouste","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie et Transplantation R\u00e9nale, Centre Hospitalier Universitaire de Clermont-Ferrand, 63000 Clermont-Ferrand, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moglie Le","family":"Quintrec","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie et Transplantation R\u00e9nale, Centre Hospitalier Universitaire de Montpellier, 34000 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Daugas","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie et Transplantation R\u00e9nale, H\u00f4pital Bichat, Assistance Publique des H\u00f4pitaux de Paris, 75018 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Huart","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie et Transplantation d\u2019Organes, Centre de R\u00e9f\u00e9rence des Maladies R\u00e9nales Rares, Centre Hospitalier Universitaire de Toulouse, 31000 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Ducloux","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie et Transplantation R\u00e9nale, Centre Hospitalier Universitaire de Besan\u00e7on, 25000 Besan\u00e7on, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Hummel","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie-Dialyse, H\u00f4pital Necker, Assistance Publique des H\u00f4pitaux de Paris, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e8s","family":"Ferrandiz","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie et Transplantation d\u2019Organes, Centre de R\u00e9f\u00e9rence des Maladies R\u00e9nales Rares, Centre Hospitalier Universitaire de Toulouse, 31000 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Demoulin","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie, Cliniques Universitaires Saint-Luc, Universit\u00e9 Catholique de Louvain, 1348 Louvain, Belgique"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9315-1577","authenticated-orcid":false,"given":"No\u00e9mie","family":"Jourde-Chiche","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9, C2VN, INSERM 1263, INRA 1260, Marseille 13005, France"},{"name":"Assistance Publique-Hopitaux de Marseille (AP-HM), Centre de N\u00e9phrologie et Transplantation r\u00e9nale, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Chauveau","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie et Transplantation d\u2019Organes, Centre de R\u00e9f\u00e9rence des Maladies R\u00e9nales Rares, Centre Hospitalier Universitaire de Toulouse, 31000 Toulouse, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1048 (Institut des Maladies Cardiovasculaires et M\u00e9taboliques-\u00e9quipe 12), 31000 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5343-2550","authenticated-orcid":false,"given":"Vincent","family":"Audard","sequence":"additional","affiliation":[{"name":"Service de N\u00e9phrologie et Transplantation, Centre de R\u00e9f\u00e9rence Maladie Rare Syndrome N\u00e9phrotique Idiopathique, H\u00f4pital Mondor, Assistance Publique des H\u00f4pitaux de Paris, Universit\u00e9 Paris-Est Cr\u00e9teil (UPEC), INSERM U955, \u00e9quipe 21, 94000 Cr\u00e9teil, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-0927","authenticated-orcid":false,"given":"Stanislas","family":"Faguer","sequence":"additional","affiliation":[{"name":"D\u00e9partement de N\u00e9phrologie et Transplantation d\u2019Organes, Centre de R\u00e9f\u00e9rence des Maladies R\u00e9nales Rares, Centre Hospitalier Universitaire de Toulouse, 31000 Toulouse, France"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1048 (Institut des Maladies Cardiovasculaires et M\u00e9taboliques-\u00e9quipe 12), 31000 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2215\/CJN.05000516","article-title":"Minimal Change Disease","volume":"12","author":"Vivarelli","year":"2017","journal-title":"Clin. 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Nephrol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/3\/298\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:35:51Z","timestamp":1760186151000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/3\/298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,2]]},"references-count":32,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3]]}},"alternative-id":["jcm8030298"],"URL":"https:\/\/doi.org\/10.3390\/jcm8030298","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,2]]}}}