{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:34:41Z","timestamp":1772753681279,"version":"3.50.1"},"reference-count":29,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T00:00:00Z","timestamp":1551916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>This study examined whether methadone (hereinafter referred to as MTD) maintenance treatment (MMT) is correlated with sexual dysfunction (SD) in heroin-dependent men. This was conducted to determine the prevalence of sexual dysfunction and if there is a relationship between duration and dose among men on MMT and its impact on the quality of life. The study combined a retrospective and a cross-sectional survey based on the Kinsey Scale, TECVASP, and PRSexDQ-SALSEX clinical interviews of 85 patients who are currently engaged in MMT. Sexual dysfunction in all five PRSexDQ-SALSEX domains (lack of libido, delay in orgasm, inability to orgasm, erectile dysfunction, and tolerance or acceptance of changes in sexual function) was associated with dose and long-term use of heroin. All dimensions of SD were affected by the MTD intake. From the analysis of our sample, we may conclude that dose of MTD and overall score of SD were directly associated. However, no evidence was found to prove that treatment duration and severity of SD were linked. It is notable that only one tenth of the patients spontaneously reported their symptoms of the sexual sphere, but up to a third considered leaving the MMT for this reason.<\/jats:p>","DOI":"10.3390\/jcm8030321","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T04:58:35Z","timestamp":1552021115000},"page":"321","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Sexual Dysfunction and Quality of Life in Chronic Heroin-Dependent Individuals on Methadone Maintenance Treatment"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7094-0511","authenticated-orcid":false,"given":"Carlos","family":"Llanes","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Complejo Asistencial de Zamora, Zamora 49022, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana I.","family":"\u00c1lvarez","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Hospital Cl\u00ednico Universitario de Salamanca, Salamanca 37007, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Teresa","family":"Pastor","sequence":"additional","affiliation":[{"name":"Castilla y Le\u00f3n Health Authority, Complejo Asistencial de Zamora, Zamora 49022, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. \u00c1ngeles","family":"Garz\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Hospital Cl\u00ednico Universitario de Salamanca, Salamanca 37007, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2814-2807","authenticated-orcid":false,"given":"Nerea","family":"Gonz\u00e1lez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Salamanca, Institute of Biomedical Research of Salamanca IBSAL, Salamanca 37007, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4383-1333","authenticated-orcid":false,"given":"\u00c1ngel L.","family":"Montejo","sequence":"additional","affiliation":[{"name":"Psychiatry, University of Salamanca, Institute of Biomedical Research of Salamanca IBSAL, Salamanca 37007, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1111\/add.12551","article-title":"The global epidemiology and burden of opioid dependence: Results from the global burden of disease 2010 study","volume":"109","author":"Degenhardt","year":"2014","journal-title":"Addiction"},{"key":"ref_2","first-page":"CD002209","article-title":"Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence","volume":"3","author":"Mattick","year":"2009","journal-title":"Cochrane Database Syst. 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