{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T02:58:43Z","timestamp":1776653923996,"version":"3.51.2"},"reference-count":39,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,3,13]],"date-time":"2019-03-13T00:00:00Z","timestamp":1552435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) is an excellent prognostic\u2013predictive tool in heart failure (HF) patients, but its plasma level changes following therapy. The comparison of prognosis\u2013predictivity of a single measurement of plasma NT-pro BNP in different follow-up periods in acute HF patients has been less studied. This study aimed to evaluate whether the association between initial plasma NT-proBNP levels and all-cause mortality would decrease along with an increased follow-up period in patients with acute HF. The retrospective study was carried out, enrolling adult patients with hospitalization-requiring acute HF who fulfilled the predefined criteria from January 1, 2011, to December 31, 2013. We evaluated the independent predictors of 12-month mortality, and subsequently compared the predictivity of NT-proBNP level at initial presentation for 1-, 3-, 6-, 9- and 12-month mortality. In total, 269 patients (mean age, 74.45 \u00b1 13.59 years; female, 53.9%) were enrolled. The independent predictors of 12-month mortality included higher \u201cCharlson Comorbidity Index\u201d (adjusted hazard ratio (aHR) = 1.22; 95% confidence interval (CI), 1.10\u20131.34), increased \u201cage\u201d (aHR = 1.07; 95% CI, 1.04\u20131.10), \u201cadministration of vasopressor\u201d (aHR = 3.43; 95% CI, 1.76\u20136.71), \u201cunderwent cardiopulmonary resuscitation\u201d (aHR = 4.59; 95% CI, 1.76\u20136.71), and without \u201cangiotensin-converting enzyme inhibitors\/angiotensin receptor blocker\u201d (aHR = 0.41; 95% CI, 1.86\u201311.31) (all p &lt;0.001). \u201cPlasma NT-pro BNP level \u226711,755 ng\/L\u201d was demonstrated as an independent predictor in 1-month (aHR = 2.37; 95% CI, 1.10\u20135.11; p = 0.028) and 3-month mortality (aHR = 1.98; 95% CI, 1.02\u20133.86; p = 0.045) but not in more extended follow-up. The outcome predictivity of plasma NT-proBNP levels diminished in a longer follow-up period in hospitalized acute HF patients. In conclusion, these findings remind physicians to act with caution when using a single plasma level of NT-proBNP to predict patient outcomes with a longer follow-up period.<\/jats:p>","DOI":"10.3390\/jcm8030357","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T04:15:29Z","timestamp":1552536929000},"page":"357","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Predictivity of N-Terminal Pro b-Type Natriuretic Peptide for All-Cause Mortality in Various Follow-Up Periods among Heart Failure Patients"],"prefix":"10.3390","volume":"8","author":[{"given":"Min-Yu","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Nursing, Saint Mary\u2019s Hospital Luodong, Luodong, Yilan 26546, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Chih","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Department of Internal medicine, Chi Mei Medical Center, Yongkang District, Tainan City 710, Taiwan"},{"name":"Department of Biological Science and Technology, Chung Hwa University of Medical Technology, Rende District, Tainan City 717, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Ting","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Nursing, Saint Mary\u2019s Hospital Luodong, Luodong, Yilan 26546, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Saint Mary\u2019s Hospital Luodong, Luodong, Yilan 26546, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2220-7574","authenticated-orcid":false,"given":"Chih-Chung","family":"Shiao","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Saint Mary\u2019s Hospital Luodong, Luodong, Yilan 26546, Taiwan"},{"name":"Saint Mary\u2019s Junior College of Medicine, Nursing and Management, Sanxing Township, Yilan County 266, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1001\/jama.2011.1474","article-title":"National and regional trends in heart failure hospitalization and mortality rates for Medicare beneficiaries, 1998\u20132008","volume":"306","author":"Chen","year":"2011","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"R291","DOI":"10.1186\/cc10584","article-title":"Baseline characteristics and hospital mortality in the Acute Heart Failure Database (AHEAD) Main registry","volume":"15","author":"Spinar","year":"2011","journal-title":"Crit. 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