{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:34:37Z","timestamp":1760240077065,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2019,3,15]],"date-time":"2019-03-15T00:00:00Z","timestamp":1552608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Zika virus (ZIKV) is a mosquito-borne pathogen that became renowned in 2015 in Brazil mainly due to its association with microcephaly in newborns. Although most infections in adults are asymptomatic or cause mild illnesses, in a reduced number of cases, ZIKV can also produce severe complications that include neurological disorders (Guillain\u2013Barr\u00e9 syndrome), ocular lesions, or reproductive alterations. From 2015 the efforts of a significant part of the scientific community were placed on ZIKV research, which has resulted in an unpredicted escalation of the knowledge of the biology and pathology of this virus. The rapid response of the scientific community against ZIKV highlights its enormous potential to counter attack a viral threat within a short time period. It is expected that this huge collaborative effort will produce affordable and effective prophylactic and therapeutic tools against ZIKV. Nevertheless, there are still other arboviral threats different from ZIKV that should not be forgotten.<\/jats:p>","DOI":"10.3390\/jcm8030369","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T04:06:55Z","timestamp":1552882015000},"page":"369","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The Scientific Response to Zika Virus"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6015-3613","authenticated-orcid":false,"given":"Miguel A.","family":"Mart\u00edn-Acebes","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria (INIA), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8269-5544","authenticated-orcid":false,"given":"Juan-Carlos","family":"Saiz","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Instituto Nacional de Investigaci\u00f3n y Tecnolog\u00eda Agraria y Alimentaria (INIA), 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,3,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Azevedo, R.S.S., Araujo, M.T., Oliveira, C.S., Filho, A.J.M., Nunes, B.T.D., Henriques, D.F., Silva, E.V.P., Carvalho, V.L., Chiang, J.O., and Martins, L.C. (2018). Zika Virus Epidemic in Brazil. II. Post-Mortem Analyses of Neonates with Microcephaly, Stillbirths, and Miscarriage. J. Clin. Med., 7.","DOI":"10.3390\/jcm7120496"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/s41586-018-0446-y","article-title":"The emergence of Zika virus and its new clinical syndromes","volume":"560","author":"Pierson","year":"2018","journal-title":"Nature"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.3389\/fmicb.2017.01554","article-title":"Zika Virus: What Have We Learnt Since the Start of the Recent Epidemic?","volume":"8","author":"Saiz","year":"2017","journal-title":"Front Microbiol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Kurscheidt, F.A., Mesquita, C.S.S., Damke, G., Damke, E., Carvalho, A., Suehiro, T.T., Teixeira, J.J.V., da Silva, V.R.S., Souza, R.P., and Consolaro, M.E.L. (2018). Persistence and clinical relevance of Zika virus in the male genital tract. Nat. Rev. Urol.","DOI":"10.1038\/s41585-019-0149-7"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tmaid.2015.07.005","article-title":"A bibliometric analysis of global Zika research","volume":"14","year":"2016","journal-title":"Travel Med. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Albuquerque, P.C., Castro, M.J., Santos-Gandelman, J., Oliveira, A.C., Peralta, J.M., and Rodrigues, M.L. (2017). Bibliometric Indicators of the Zika Outbreak. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005132"},{"key":"ref_7","first-page":"13","article-title":"Zika virus, from discovery to the present days: bibliometric review study","volume":"9","author":"Dionalisio","year":"2017","journal-title":"Int. J. Curr. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/0194262X.2018.1431589","article-title":"Bibliometric Analysis of Scholarly Publications on the Zika Virus, 1952\u20132016","volume":"37","author":"Delwiche","year":"2018","journal-title":"Sci. Tech. Libr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1016\/S1473-3099(16)30473-X","article-title":"Dengue: knowledge gaps, unmet needs, and research priorities","volume":"17","author":"Katzelnick","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.3390\/v5123088","article-title":"West nile virus in the United States - a historical perspective","volume":"5","author":"Roehrig","year":"2013","journal-title":"Viruses"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.antiviral.2015.04.016","article-title":"Chikungunya: Evolutionary history and recent epidemic spread","volume":"120","author":"Weaver","year":"2015","journal-title":"Antiviral Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12992-016-0194-4","article-title":"Understanding Ebola: the 2014 epidemic","volume":"12","author":"Kaner","year":"2016","journal-title":"Global Health"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"0408021","DOI":"10.1115\/1.4041086","article-title":"Advances in Diagnostic Methods for Zika Virus Infection","volume":"12","author":"Herrada","year":"2018","journal-title":"J. Med. Device"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Nazerai, L., Pravsgaard Christensen, J., and Randrup Thomsen, A. (2019). A \u2019Furry-Tale\u2019 of Zika Virus Infection: What Have We Learned from Animal Models?. Viruses, 11.","DOI":"10.3390\/v11010029"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/infdis\/jiy572","article-title":"Can We Better Understand How Zika Leads to Microcephaly? A Systematic Review of the Effects of the Zika Virus on Human Brain Organoids","volume":"219","author":"Sutarjono","year":"2019","journal-title":"J. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1101\/gad.298216.117","article-title":"How does Zika virus cause microcephaly?","volume":"31","author":"Wen","year":"2017","journal-title":"Genes Dev."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e00411","DOI":"10.1128\/AAC.00411-17","article-title":"The Race To Find Antivirals for Zika Virus","volume":"61","author":"Saiz","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/s41594-017-0010-8","article-title":"Structural biology of Zika virus and other flaviviruses","volume":"25","author":"Hasan","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/nrd.2017.33","article-title":"Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond","volume":"16","author":"Boldescu","year":"2017","journal-title":"Nat. Rev. Drug. Discov."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"725","DOI":"10.7326\/M16-2530","article-title":"Clinical Trials of Therapeutics for the Prevention of Congenital Zika Virus Disease: Challenges and Potential Solutions","volume":"166","author":"Salam","year":"2017","journal-title":"Ann. Intern. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1146\/annurev-med-040717-051127","article-title":"Zika Virus Vaccine Development: Progress in the Face of New Challenges","volume":"70","author":"Diamond","year":"2018","journal-title":"Annu. Rev. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0140-6736(18)32560-1","article-title":"Dengue","volume":"393","author":"Ooi","year":"2019","journal-title":"Lancet"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"10498","DOI":"10.1038\/s41598-017-10901-1","article-title":"Prior Exposure to Zika Virus Significantly Enhances Peak Dengue-2 Viremia in Rhesus Macaques","volume":"7","author":"George","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.chom.2018.09.015","article-title":"Maternally Acquired Zika Antibodies Enhance Dengue Disease Severity in Mice","volume":"24","author":"Fowler","year":"2018","journal-title":"Cell Host Microbe"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.cell.2017.02.017","article-title":"Modified mRNA Vaccines Protect against Zika Virus Infection","volume":"168","author":"Richner","year":"2017","journal-title":"Cell"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"ofy151","DOI":"10.1093\/ofid\/ofy151","article-title":"Human Serum with High Neutralizing Antibody Titers Against Both Zika and Dengue Virus Shows Delayed In Vitro Antibody-Dependent Enhancement of Dengue Virus Infection","volume":"5","author":"Valiant","year":"2018","journal-title":"Open Forum Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41426-018-0132-z","article-title":"Zika convalescent macaques display delayed induction of anamnestic cross-neutralizing antibody responses after dengue infection","volume":"7","author":"Valiant","year":"2018","journal-title":"Emerg. Microbes Infect."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fcimb.2018.00044","article-title":"Antibody-Dependent Enhancement and Zika: Real Threat or Phantom Menace?","volume":"8","author":"Saiz","year":"2018","journal-title":"Front Cell Infect. Microbiol."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/3\/369\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:39:15Z","timestamp":1760186355000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/3\/369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,15]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3]]}},"alternative-id":["jcm8030369"],"URL":"https:\/\/doi.org\/10.3390\/jcm8030369","relation":{},"ISSN":["2077-0383"],"issn-type":[{"type":"electronic","value":"2077-0383"}],"subject":[],"published":{"date-parts":[[2019,3,15]]}}}