{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T19:01:41Z","timestamp":1773687701998,"version":"3.50.1"},"reference-count":29,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,4,2]],"date-time":"2019-04-02T00:00:00Z","timestamp":1554163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>The impact of incidentally identified diffuse thyroid FDG uptake on 18F-FDG PET\/CT scan on the incidence of thyroid dysfunction remains unclear. We examined the association of diffuse thyroid FDG uptake with the development of thyroid dysfunction. This cohort study involved 39,098 Korean adults who were free of malignancy and thyroid disease at baseline and underwent regular health checkup examinations including an 18F-FDG whole body PET\/CT scan, thyroid-stimulating hormone and free thyroxine. The participants were annually or biennially followed for up to 5 years. A parametric proportional hazard model was used to estimate the adjusted hazard ratio (HR) and 95% confidence interval (CI). Diffuse thyroid uptake was positively associated with increased risk of thyroid dysfunction in both the cross-sectional and cohort studies. During 104,261.4 person-years of follow-up, 102 incident hypothyroidism cases and 172 hyperthyroidism cases were identified. Multivariable-adjusted HR (95% CI) for incident hypothyroidism or hyperthyroidism comparing diffuse thyroid uptake to no uptake were 15.72 (9.23\u201326.77) and 7.38 (4.23\u201312.87), respectively. In this large cohort, incidentally, identified diffuse thyroid uptake on 18F-FDG PET\/CT was associated with increased risk of both prevalent and incident thyroid dysfunction. Therefore, baseline and follow-up evaluations in individuals with diffuse thyroid uptake may help identify individuals with thyroid dysfunction.<\/jats:p>","DOI":"10.3390\/jcm8040443","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T03:39:28Z","timestamp":1554262768000},"page":"443","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Diffusely Increased 18F-FDG Uptake in the Thyroid Gland and Risk of Thyroid Dysfunction: A Cohort Study"],"prefix":"10.3390","volume":"8","author":[{"given":"Young Hwan","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 03181 Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6945-9050","authenticated-orcid":false,"given":"Yoosoo","family":"Chang","sequence":"additional","affiliation":[{"name":"Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 04514 Seoul, Korea"},{"name":"Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 03181 Seoul, Korea"},{"name":"Department of Clinical Research Design &amp; Evaluation, SAIHST, Sungkyunkwan University, 06351 Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yejin","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 04514 Seoul, Korea"},{"name":"Department of Clinical Research Design &amp; Evaluation, SAIHST, Sungkyunkwan University, 06351 Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Jeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 03181 Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun-Jung","family":"Rhee","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 03181 Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyemi","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 03181 Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiin","family":"Ahn","sequence":"additional","affiliation":[{"name":"Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 04514 Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3927-8646","authenticated-orcid":false,"given":"Seungho","family":"Ryu","sequence":"additional","affiliation":[{"name":"Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 04514 Seoul, Korea"},{"name":"Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 03181 Seoul, Korea"},{"name":"Department of Clinical Research Design &amp; Evaluation, SAIHST, Sungkyunkwan University, 06351 Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.crad.2014.12.020","article-title":"Clinical significance of patterns of incidental thyroid uptake at (18)F-FDG PET\/CT","volume":"70","author":"Agrawal","year":"2015","journal-title":"Clin. Radiol."},{"key":"ref_2","first-page":"1038","article-title":"Targeting glucose transporters for tumor imaging: \u201csweet\u201d idea, \u201csour\u201d result","volume":"37","author":"Wahl","year":"1996","journal-title":"J. Nucl. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.crad.2010.12.004","article-title":"False-positive uptake on 2-[(1)(8)F]-fluoro-2-deoxy-D-glucose (FDG) positron-emission tomography\/computed tomography (PET\/CT) in oncological imaging","volume":"66","author":"Culverwell","year":"2011","journal-title":"Clin. Radiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s12149-008-0198-0","article-title":"Clinical significance of thyroid uptake on F18-fluorodeoxyglucose positron emission tomography","volume":"23","author":"Liu","year":"2009","journal-title":"Ann. Nucl. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0889-8529(05)70123-7","article-title":"Thyroid incidentalomas. Prevalence, diagnosis, significance, and management","volume":"29","author":"Burguera","year":"2000","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1148\/radiographics.19.1.g99ja0761","article-title":"Pitfalls in oncologic diagnosis with FDG PET imaging: Physiologic and benign variants","volume":"19","author":"Shreve","year":"1999","journal-title":"Radiographics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1148\/radiology.207.3.9609903","article-title":"Chronic thyroiditis: Diffuse uptake of FDG at PET","volume":"207","author":"Yasuda","year":"1998","journal-title":"Radiology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1245\/s10434-006-9181-y","article-title":"FDG-PET detected thyroid incidentalomas: Need for further investigation?","volume":"14","author":"Are","year":"2007","journal-title":"Ann. Surg. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"896","DOI":"10.2967\/jnumed.106.039024","article-title":"Clinical significance of diffusely increased 18F-FDG uptake in the thyroid gland","volume":"48","author":"Karantanis","year":"2007","journal-title":"J. Nucl. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.7326\/M15-1323","article-title":"Metabolically Healthy Obesity and Development of Chronic Kidney Disease: A Cohort Study","volume":"164","author":"Chang","year":"2016","journal-title":"Ann. Intern. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1249\/01.MSS.0000078924.61453.FB","article-title":"International physical activity questionnaire: 12-country reliability and validity","volume":"35","author":"Craig","year":"2003","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/sj.ejcn.1602657","article-title":"Validation and reproducibility of food frequency questionnaire for Korean genome epidemiologic study","volume":"61","author":"Ahn","year":"2007","journal-title":"Eur. J. Clin. Nutr."},{"key":"ref_13","unstructured":"World Health Organization, and Regional Office for the Western Pacific (2000). The Asia-Pacific Perspective: Redefining Obesity and Its Treatment, Health Communications Australia."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1002\/sim.1203","article-title":"Flexible parametric proportional-hazards and proportional-odds models for censored survival data, with application to prognostic modelling and estimation of treatment effects","volume":"21","author":"Royston","year":"2002","journal-title":"Stat. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1089\/thy.2012.0005","article-title":"Risk of malignancy in thyroid incidentalomas detected by 18F-fluorodeoxyglucose positron emission tomography: A systematic review","volume":"22","author":"Soelberg","year":"2012","journal-title":"Thyroid"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s12149-007-0030-2","article-title":"Diffuse and diffuse-plus-focal uptake in the thyroid gland identified by using FDG-PET: Prevalence of thyroid cancer and Hashimoto\u2019s thyroiditis","volume":"21","author":"Kurata","year":"2007","journal-title":"Ann. Nucl. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s00405-011-1512-3","article-title":"Incidence of diffuse FDG uptake in the thyroid of patients with hypothyroidism","volume":"268","author":"Rothman","year":"2011","journal-title":"Eur. Arch. Otorhinolaryngol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3348\/kjr.2013.14.3.501","article-title":"Diffuse thyroid uptake incidentally found on 18F-fluorodeoxyglucose positron emission tomography in subjects without cancer history","volume":"14","author":"Lee","year":"2013","journal-title":"Korean J. Radiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1097\/01.MLG.0000163098.01398.79","article-title":"18F-fluorodeoxyglucose uptake in thyroid from positron emission tomogram (PET) for evaluation in cancer patients: High prevalence of malignancy in thyroid PET incidentaloma","volume":"115","author":"Kim","year":"2005","journal-title":"Laryngoscope"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4103\/0972-3919.147528","article-title":"Does the intensity of diffuse thyroid gland uptake on F-18 fluorodeoxyglucose positron emission tomography\/computed tomography scan predict the severity of hypothyroidism? Correlation between maximal standardized uptake value and serum thyroid stimulating hormone levels","volume":"30","author":"Pruthi","year":"2015","journal-title":"Indian J. Nucl. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1093\/bmb\/ldr030","article-title":"The epidemiology of thyroid disease","volume":"99","author":"Vanderpump","year":"2011","journal-title":"Br. Med. Bull."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1056\/NEJM200106073442302","article-title":"Increased need for thyroxine in women with hypothyroidism during estrogen therapy","volume":"344","author":"Arafah","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"875125","DOI":"10.4061\/2011\/875125","article-title":"Role of estrogen in thyroid function and growth regulation","volume":"2011","author":"Santin","year":"2011","journal-title":"J. Thyroid Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/cen.13750","article-title":"Are pregnancy, parity, menstruation and breastfeeding risk factors for thyroid cancer? Results from the Korea National Health and Nutrition Examination Survey, 2010\u20132015","volume":"89","author":"Kim","year":"2018","journal-title":"Clin. Endocrinol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/MNM.0b013e328013eaf7","article-title":"The significance of FDG uptake in bilateral thyroid glands","volume":"28","author":"Chen","year":"2007","journal-title":"Nucl. Med. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1089\/thy.1998.8.765","article-title":"Glucose metabolism of the thyroid in Graves\u2019 disease measured by F-18-fluoro-deoxyglucose positron emission tomography","volume":"8","author":"Boerner","year":"1998","journal-title":"Thyroid"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1097\/RLU.0b013e318148b47d","article-title":"Diagnostic trinity: Graves\u2019 disease on F-18 FDG PET","volume":"32","author":"Chen","year":"2007","journal-title":"Clin. Nucl. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1210\/jcem.87.7.8678","article-title":"Prospective study of the spontaneous course of subclinical hypothyroidism: Prognostic value of thyrotropin, thyroid reserve, and thyroid antibodies","volume":"87","author":"Huber","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_29","first-page":"362","article-title":"Serum TSH level stability after 5 years in euthyroid adults at low risk for thyroid dysfunction","volume":"62","author":"Rosario","year":"2018","journal-title":"Arch. Endocrinol. Metab."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/4\/443\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:42:23Z","timestamp":1760186543000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/4\/443"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,2]]},"references-count":29,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4]]}},"alternative-id":["jcm8040443"],"URL":"https:\/\/doi.org\/10.3390\/jcm8040443","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,2]]}}}