{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T02:15:37Z","timestamp":1772676937225,"version":"3.50.1"},"reference-count":43,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T00:00:00Z","timestamp":1554422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Norwegian ExtraFoundation for Health and Rehabilitation","award":["2016\/FO76163"],"award-info":[{"award-number":["2016\/FO76163"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Fatigue is a common symptom in patients with sarcoidosis. Despite lacking evidence on whether high-intensity interval training (HIIT) will aggravate fatigue, moderate-intensity exercise is often recommended. This study aimed to investigate whether a single session of HIIT would affect fatigue differently from a single session of moderate-intensity continuous training (MICT). Methods: Forty-one patients with pulmonary sarcoidosis were recruited to a cross-over study. All patients completed one treadmill session of HIIT (85% of peak heart rate (HRpeak)) and one of MICT (70% of HRpeak). Fatigue was assessed with the Visual Analogue Scale 0\u2013100 mm, before (T0), after (T1), and 24 hours after (T2) each exercise session. Paired sample t-test was used to compare changes in fatigue from T0 to T1 and from T0 to T2 between HIIT and MICT. Results: No statistically significant difference in fatigue levels was found between HIIT and MICT, either at T1 (3.6 (13.5) and 1.4 (13.5)) or at T2 (8.2 (17.0) and 2.1 (17.1)). Conclusions: A single session of HIIT did not affect fatigue differently than a single session of MICT. These preliminary findings support the need for further research on the long-term effect of HIIT on fatigue in patients with sarcoidosis.<\/jats:p>","DOI":"10.3390\/jcm8040460","type":"journal-article","created":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T11:36:01Z","timestamp":1554464161000},"page":"460","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Effects of High- Versus Moderate-Intensity Exercise on Fatigue in Sarcoidosis"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0582-3431","authenticated-orcid":false,"given":"Anita","family":"Grongstad","sequence":"first","affiliation":[{"name":"LHL Hospital Gardermoen, 2067 NO Jessheim, Norway"},{"name":"Department of Interdisciplinary Health Sciences, University of Oslo, 0318 NO Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7575-6625","authenticated-orcid":false,"given":"Nina","family":"V\u00f8llestad","sequence":"additional","affiliation":[{"name":"Department of Interdisciplinary Health Sciences, University of Oslo, 0318 NO Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Line","family":"Oldervoll","sequence":"additional","affiliation":[{"name":"LHL, Clinics Trondheim, 7041 NO Trondheim, Norway"},{"name":"Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Technology and Science (NTNU), 7491 NO Trondheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3822-7430","authenticated-orcid":false,"given":"Martijn","family":"Spruit","sequence":"additional","affiliation":[{"name":"Department of Research &amp; Education, CIRO, Center of Expertise for Chronic Organ Failure, 6085 NM Horn, The Netherlands"},{"name":"Department of Respiratory Medicine, Maastricht University Medical Centre, NUTRIM School of Nutrition and Translational Research in Metabolism, 6229 HX Maastricht, The Netherlands"},{"name":"REVAL\u2014Rehabilitation Research Center, BIOMED\u2014Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, 3590 BE Diepenbeek, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Edvardsen","sequence":"additional","affiliation":[{"name":"LHL Hospital Gardermoen, 2067 NO Jessheim, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,5]]},"reference":[{"key":"ref_1","first-page":"149","article-title":"ATS\/ERS\/WASOG statement on sarcoidosis. American Thoracic Society\/European Respiratory Society\/World Association of Sarcoidosis and other Granulomatous Disorders","volume":"16","author":"Hunninghake","year":"1999","journal-title":"Sarcoidosis Vasc. Diffuse Lung Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/MCP.0b013e32832d0403","article-title":"Fatigue in sarcoidosis: A systematic review","volume":"15","author":"Lower","year":"2009","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1183\/09031936.00002512","article-title":"Sarcoidosis-associated fatigue","volume":"40","author":"Drent","year":"2012","journal-title":"Eur. Respir. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/MCP.0b013e328363f563","article-title":"Reduced muscle strength, exercise intolerance and disabling symptoms in sarcoidosis","volume":"19","author":"Marcellis","year":"2013","journal-title":"Curr. Opin. Pulm. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00408-015-9784-9","article-title":"Benefits of Physical Training in Sarcoidosis","volume":"193","author":"Strookappe","year":"2015","journal-title":"Lung"},{"key":"ref_6","first-page":"43","article-title":"Benefits of physical training in patients with idiopathic or end-stage sarcoidosis-related pulmonary fibrosis: A pilot study","volume":"32","author":"Strookappe","year":"2015","journal-title":"Sarcoidosis Vasc. Diffuse Lung Dis."},{"key":"ref_7","first-page":"53","article-title":"Does physical training reduce fatigue in sarcoidosis?","volume":"32","author":"Marcellis","year":"2015","journal-title":"Sarcoidosis Vasc. Diffuse Lung Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/HCR.0000000000000307","article-title":"Efficacy of a Structured Exercise Program for Improving Functional Capacity and Quality of Life in Patients with Stage 3 and 4 Sarcoidosis: A RANDOMIZED CONTROLLED TRIAL","volume":"38","author":"Naz","year":"2018","journal-title":"J. Cardiopulm. Rehabil. Prev."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1177\/1479972316661926","article-title":"Managing fatigue in sarcoidosis\u2014A systematic review of the evidence","volume":"14","author":"Atkins","year":"2017","journal-title":"Chronic Respir. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1113\/jphysiol.2011.224725","article-title":"Physiological adaptations to low-volume, high-intensity interval training in health and disease","volume":"590","author":"Gibala","year":"2012","journal-title":"J. Physiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s40279-015-0321-z","article-title":"The impact of high-intensity interval training versus moderate-intensity continuous training on vascular function: A systematic review and meta-analysis","volume":"45","author":"Ramos","year":"2015","journal-title":"Sports Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/OAJSM.S150596","article-title":"High-intensity interval training versus moderate-intensity continuous training within cardiac rehabilitation: A systematic review and meta-analysis","volume":"9","author":"Hannan","year":"2018","journal-title":"Open Access J. Sports Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/CRD.0000000000000124","article-title":"High-Intensity Interval Training Versus Moderate-Intensity Continuous Training in the Prevention\/Management of Cardiovascular Disease","volume":"24","author":"Hussain","year":"2016","journal-title":"Cardiol. Rev."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/PHM.0000000000000083","article-title":"Effect of exercise on cancer-related fatigue: A meta-analysis","volume":"93","author":"Tomlinson","year":"2014","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_15","first-page":"CD003200","article-title":"Exercise therapy for chronic fatigue syndrome","volume":"4","author":"Larun","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1249\/MSS.0000000000000983","article-title":"Fatigue Exacerbation by Interval or Continuous Exercise in Chronic Fatigue Syndrome","volume":"48","author":"Sandler","year":"2016","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1183\/09031936.05.00035005","article-title":"Standardisation of the measurement of lung volumes","volume":"26","author":"Wanger","year":"2005","journal-title":"Eur. Respir. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1183\/09041950.085s1693","article-title":"Symbols, abbreviations and units. Working Party Standardization of Lung Function Tests, European Community for Steel and Coal","volume":"16","author":"Quanjer","year":"1993","journal-title":"Eur. Respir. J. Suppl."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1378\/chest.12-1458","article-title":"Reference values for cardiorespiratory response and fitness on the treadmill in a 20- to 85-year-old population","volume":"144","author":"Edvardsen","year":"2013","journal-title":"Chest"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories (2002). ATS statement: Guidelines for the six-minute walk test. Am. J. Respir. Crit. Care Med., 166, 111\u2013117.","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1348\/1359107041557048","article-title":"Measuring fatigue in sarcoidosis: The Fatigue Assessment Scale (FAS)","volume":"9","author":"Michielsen","year":"2004","journal-title":"Br. J. Health Psychol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1027\/1015-5759.20.1.39","article-title":"Examination of the dimensionality of fatigue: The construction of the Fatigue Assessment Scale (FAS)","volume":"20","author":"Michielsen","year":"2004","journal-title":"Eur. J. Psychol. Assess."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1249\/00005768-198205000-00012","article-title":"Psychophysical bases of perceived exertion","volume":"14","author":"Borg","year":"1982","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Roos, L., Taube, W., Beeler, N., and Wyss, T. (2017). Validity of sports watches when estimating energy expenditure during running. BMC Sports Sci. Med. Rehabil., 9.","DOI":"10.1186\/s13102-017-0089-6"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bbi.2013.05.006","article-title":"Influence of repeated maximal exercise testing on biomarkers and fatigue in sarcoidosis","volume":"33","author":"Braam","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1752-699X.2010.00214.x","article-title":"Fatigue and plasma cytokine concentrations at rest and during exercise in patients with sarcoidosis","volume":"5","author":"Baydur","year":"2011","journal-title":"Clin. Respir. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.rmed.2016.05.010","article-title":"Predictors of fatigue in sarcoidosis: The value of exercise testing","volume":"116","author":"Strookappe","year":"2016","journal-title":"Respir. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.3899\/jrheum.090084","article-title":"Test-retest reliability of patient global assessment and physician global assessment in rheumatoid arthritis","volume":"36","author":"Rohekar","year":"2009","journal-title":"J. Rheumatol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Yates, H., Adamali, H.I., Maskell, N., Barratt, S., and Sharp, C. (2018). Visual analogue scales for interstitial lung disease: A prospective validation study. QJM Mon. J. Assoc. Physicians.","DOI":"10.1183\/1393003.congress-2017.PA2489"},{"key":"ref_30","first-page":"1261","article-title":"Preliminary evaluation of a visual analog function scale for use in rheumatoid arthritis","volume":"32","author":"Wolfe","year":"2005","journal-title":"J. Rheumatol."},{"key":"ref_31","first-page":"280","article-title":"Determining the minimal clinically important differences in activity, fatigue, and sleep quality in patients with rheumatoid arthritis","volume":"34","author":"Wells","year":"2007","journal-title":"J. Rheumatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/bs.pmbts.2015.07.003","article-title":"Exercise and the Regulation of Inflammatory Responses","volume":"135","author":"Allen","year":"2015","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1080\/17476348.2016.1227244","article-title":"Physical activity and training in sarcoidosis: Review and experience-based recommendations","volume":"10","author":"Strookappe","year":"2016","journal-title":"Expert Rev. Respir. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1249\/MSS.0b013e318213fefb","article-title":"American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: Guidance for prescribing exercise","volume":"43","author":"Garber","year":"2011","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/thx.2004.022244","article-title":"Skeletal muscle weakness in patients with sarcoidosis and its relationship with exercise intolerance and reduced health status","volume":"60","author":"Spruit","year":"2005","journal-title":"Thorax"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/5584_2014_18","article-title":"Fatigue in sarcoidosis and exercise tolerance, dyspnea, and quality of life","volume":"833","author":"Jastrzebski","year":"2015","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/JES.0b013e318168ec1f","article-title":"Metabolic adaptations to short-term high-intensity interval training: A little pain for a lot of gain?","volume":"36","author":"Gibala","year":"2008","journal-title":"Exerc. Sport Sci. Rev."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/02640414.2010.545427","article-title":"High-intensity interval running is perceived to be more enjoyable than moderate-intensity continuous exercise: Implications for exercise adherence","volume":"29","author":"Bartlett","year":"2011","journal-title":"J. Sports Sci."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Ungprasert, P., Wijarnpreecha, K., Cheungpasitporn, W., Thongprayoon, C., Manatsathit, W., and Kroner, P.T. (2019). Inpatient Prevalence, Expenditures, and Comorbidities of Sarcoidosis: Nationwide Inpatient Sample 2013\u20132014. Lung.","DOI":"10.1136\/annrheumdis-2019-eular.514"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/5584_2017_87","article-title":"Predominance of Comorbidities in the Detriment of Daily Activity in Sarcoidosis Patients","volume":"1040","author":"Kostorz","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/01.hjr.0000131677.96762.0c","article-title":"High intensity aerobic interval exercise is superior to moderate intensity exercise for increasing aerobic capacity in patients with coronary artery disease","volume":"11","author":"Rognmo","year":"2004","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1161\/CIRCULATIONAHA.108.772822","article-title":"Aerobic interval training versus continuous moderate exercise as a treatment for the metabolic syndrome: A pilot study","volume":"118","author":"Tjonna","year":"2008","journal-title":"Circulation"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1161\/CIRCULATIONAHA.106.675041","article-title":"Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: A randomized study","volume":"115","author":"Wisloff","year":"2007","journal-title":"Circulation"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/4\/460\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:43:12Z","timestamp":1760186592000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/4\/460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,5]]},"references-count":43,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4]]}},"alternative-id":["jcm8040460"],"URL":"https:\/\/doi.org\/10.3390\/jcm8040460","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,5]]}}}