{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T06:34:13Z","timestamp":1781246053840,"version":"3.54.1"},"reference-count":30,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:00:00Z","timestamp":1555027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Studies are extremely limited for the investigation of the clinical outcome of da Vinci robot-assisted bilateral internal mammary artery (BIMA) grafting in coronary artery bypass grafting (CABG) surgery. This study aimed to explore the short-term outcome of da Vinci robot-assisted BIMA grafting through the left pleural space. Relevant data were collected from patients with multi-vessel coronary artery disease receiving two kinds of CABG: a group of patients receiving da Vinci robot-assisted CABG with BIMA grafting, and another group of patients receiving sternotomy CABG with BIMA grafting. Primary endpoints, which included cardiovascular and renal endpoints, were analyzed between the groups using the chi-square test, analysis of variance test, and Kaplan\u2013Meier analysis. Compared with the conventional group (n = 22), the robotic group (n = 22) had a significantly longer operation time (12.7 \u00b1 1.7 vs. 8.5 \u00b1 1.5 hours; p &lt; 0.01) and a marginally lower mean of serum creatinine at baseline (1.2 \u00b1 0.3 vs. 2.0 \u00b1 1.7 mg\/dL; p = 0.04). Primary endpoints (5, 22.7% vs. 12, 54.5%; p = 0.03) and renal endpoints (1, 4.5% vs. 7, 31.8%; p = 0.02) at six months were significantly reduced in the robotic group compared with the conventional group. There were no differences in cardiovascular endpoints at six months between the groups (1, 4.5% vs. 0; p = 1.00). The data showed that da Vinci robot-assisted BIMA grafting was safe, with equal cardiovascular events and lowered renal events at six months, as compared to conventional sternotomy BIMA grafting, despite the longer procedure time. The short-term study suggests that da Vinci robot-assisted BIMA grafting may be considered a favorable surgical option for patients with severe coronary artery disease.<\/jats:p>","DOI":"10.3390\/jcm8040502","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T12:55:04Z","timestamp":1555073704000},"page":"502","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Outcome of Robot-Assisted Bilateral Internal Mammary Artery Grafting via Left Pleura in Coronary Bypass Surgery"],"prefix":"10.3390","volume":"8","author":[{"given":"Chieh-Jen","family":"Wu","sequence":"first","affiliation":[{"name":"Cardiovascular Center, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan"},{"name":"Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5662-5945","authenticated-orcid":false,"given":"Hsin-Hung","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan"},{"name":"Yuh-Ing Junior College of Health Care &amp; Management, Kaohsiung 821, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4920-5942","authenticated-orcid":false,"given":"Pei-Wen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan"},{"name":"Yuh-Ing Junior College of Health Care &amp; Management, Kaohsiung 821, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hsien","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Medicine, National Yang-Ming University, Taipei 112, Taiwan"},{"name":"Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Jiunn","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan"},{"name":"School of Medicine, National Yang-Ming University, Taipei 112, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Cheng","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kaohsiung Municipal United Hospital, Kaohsiung 804, Taiwan"},{"name":"Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2949","DOI":"10.1093\/eurheartj\/eht296","article-title":"2013 ESC guidelines on the management of stable coronary artery disease: The task force on the management of stable coronary artery disease of the European society of cardiology","volume":"34","author":"Montalescot","year":"2013","journal-title":"Eur. Heart J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.jtcvs.2013.01.026","article-title":"Impact of European Society of Cardiology and European Association for Cardiothoracic Surgery Guidelines on Myocardial Revascularization on the activity of percutaneous coronary intervention and coronary artery bypass graft surgery for stable coronary artery disease","volume":"147","author":"Yates","year":"2014","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.jtcvs.2014.11.002","article-title":"2014 ACC\/AHA\/AATS\/PCNA\/SCAI\/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease: A report of the american college of cardiology\/american heart association task force on practice guidelines, and the american association for thoracic surgery, preventive cardiovascular nurses association, society for cardiovascular angiography and interventions, and society of thoracic surgeons","volume":"149","author":"Fihn","year":"2015","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/S0022-5223(94)70470-8","article-title":"Risk factors for operative mortality and sternal wound infection in bilateral internal mammary artery grafting","volume":"107","author":"He","year":"1994","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.athoracsur.2012.11.068","article-title":"Bilateral Internal Thoracic Artery Harvest and Deep Sternal Wound Infection in Diabetic Patients","volume":"95","author":"Deo","year":"2013","journal-title":"Ann. Thorac. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.athoracsur.2012.12.038","article-title":"Bilateral Internal Mammary Artery Grafting and Risk of Sternal Wound Infection: Evidence from Observational Studies","volume":"95","author":"Dai","year":"2013","journal-title":"Ann. Thorac. Surg."},{"key":"ref_7","first-page":"390","article-title":"A meta-analysis comparing bilateral internal mammary artery with left internal mammary artery for coronary artery bypass grafting","volume":"2","author":"Weiss","year":"2013","journal-title":"Ann. Cardiothorac. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/ejcts\/ezw120","article-title":"Complete myocardial revascularization using only bilateral internal thoracic arteries provides a low-risk and durable 10-year clinical outcome","volume":"50","author":"Glineur","year":"2016","journal-title":"Eur. J. Cardio-Thorac. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S130","DOI":"10.1161\/CIRCULATIONAHA.110.010892","article-title":"Off-Pump Bilateral Versus Single Skeletonized Internal Thoracic Artery Grafting in High-Risk Patients","volume":"124","author":"Kinoshita","year":"2011","journal-title":"Circulation"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jtcvs.2015.04.058","article-title":"Off-pump bilateral skeletonized internal thoracic artery grafting in patients with chronic kidney disease","volume":"150","author":"Kinoshita","year":"2015","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/ejcts\/ezu206","article-title":"Bilateral internal thoracic artery grafting increases long-term survival in elderly patients","volume":"47","author":"Pettinari","year":"2015","journal-title":"Eur. J. Cardiothorac. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jtcvs.2011.12.026","article-title":"Bilateral internal thoracic artery grafting improves long-term survival in patients with reduced ejection fraction: A propensity-matched study with 30-year follow-up","volume":"143","author":"Galbut","year":"2012","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.athoracsur.2012.03.082","article-title":"Bilateral Internal Thoracic Artery Grafting Is Associated with Significantly Improved Long-Term Survival, Even Among Diabetic Patients","volume":"94","author":"Puskas","year":"2012","journal-title":"Ann. Thorac. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Dal\u00e9n, M., Ivert, T., Holzmann, M.J., and Sartipy, U. (2014). Bilateral versus Single Internal Mammary Coronary Artery Bypass Grafting in Sweden from 1997\u20132008. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0086929"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.athoracsur.2015.04.054","article-title":"Robotic Total Arterial Off-Pump Coronary Artery Bypass Grafting: Seven-Year Single-Center Experience and Long-Term Follow-Up of Graft Patency","volume":"100","author":"Yang","year":"2015","journal-title":"Ann. Thorac. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"459","DOI":"10.21037\/jtd.2016.02.67","article-title":"Robot-assisted coronary artery bypass grafting improves short-term outcomes compared with minimally invasive direct coronary artery bypass grafting","volume":"8","author":"Gong","year":"2016","journal-title":"J. Thorac. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1253\/circj.CJ-13-1115","article-title":"Robot-Assisted Minimally Invasive Direct Coronary Artery Bypass Grafting","volume":"78","author":"Ishikawa","year":"2014","journal-title":"ThoraCAB Circ. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.5935\/1678-9741.20140019","article-title":"Mammary artery harvesting using the Da Vinci Si robotic system","volume":"29","author":"Canale","year":"2014","journal-title":"Rev. Bras. Cir. Cardiovasc."},{"key":"ref_19","first-page":"790","article-title":"Traditional coronary artery bypass graft versus totally endoscopic coronary artery bypass graft or robot-assisted coronary artery bypass graft-meta-analysis of 16 studies","volume":"18","author":"Wang","year":"2014","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1053\/j.ajkd.2014.01.416","article-title":"KDOQI US Commentary on the 2012 KDIGO Clinical Practice Guideline for the Evaluation and Management of CKD","volume":"63","author":"Inker","year":"2014","journal-title":"Am. J. Kidney Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/icvts\/ivt254","article-title":"Impact of occult renal impairment on early and late outcomes following coronary artery bypass grafting","volume":"17","author":"Marui","year":"2013","journal-title":"Interact. Cardiovasc. Thorac. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1161\/CIRCULATIONAHA.105.580084","article-title":"Impact of renal dysfunction on outcomes of coronary artery bypass surgery: Results from the society of thoracic surgeons national adult cardiac database","volume":"113","author":"Cooper","year":"2006","journal-title":"Circulation"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1161\/CIRCULATIONAHA.105.591990","article-title":"Renal function and outcome from coronary artery bypass grafting: Impact on mortality after a 2.3-year follow-up","volume":"113","author":"Hillis","year":"2006","journal-title":"Circulation"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1161\/CIRCULATIONAHA.114.010622","article-title":"Acute Kidney Injury After Coronary Artery Bypass Grafting and Long-Term Risk of End-Stage Renal Disease","volume":"130","author":"Sartipy","year":"2014","journal-title":"Circulation"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1161\/CIRCULATIONAHA.106.677070","article-title":"Multivariable Prediction of Renal Insufficiency Developing After Cardiac Surgery","volume":"116","author":"Brown","year":"2007","journal-title":"Circulation"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1253\/circj.66.921","article-title":"Does Off-Pump Coronary Artery Bypass Grafting Really Preserve Renal Function?","volume":"66","author":"Hayashida","year":"2002","journal-title":"Circ. J."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1253\/circj.CJ-11-1539","article-title":"Effect of Elapsed Time from Coronary Angiography Until Off-Pump Coronary Artery Bypass Surgery on Postoperative Renal Function","volume":"76","author":"Ji","year":"2012","journal-title":"Circ. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.jtcvs.2011.04.039","article-title":"Surgical problems and complex procedures: Issues for operative time in robotic totally endoscopic coronary artery bypass grafting","volume":"143","author":"Wiedemann","year":"2012","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/j.athoracsur.2003.09.074","article-title":"Robotic skeletonizing of the internal thoracic artery: Is it safe?","volume":"77","author":"Bolotin","year":"2004","journal-title":"Ann. Thorac. Surg."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Ragosta, M., and Singh, K.P. (2018). Robotic-Assisted Percutaneous Coronary Intervention: Rationale, Implementation, Case Selection and Limitations of Current Technology. J. Clin. Med., 7.","DOI":"10.3390\/jcm7020023"}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/4\/502\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:44:54Z","timestamp":1760186694000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/4\/502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,12]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4]]}},"alternative-id":["jcm8040502"],"URL":"https:\/\/doi.org\/10.3390\/jcm8040502","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,12]]}}}