{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:18:42Z","timestamp":1792023522174,"version":"4.4.0"},"reference-count":39,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T00:00:00Z","timestamp":1555545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Hidradenitis suppurativa (HS) is a chronic auto-inflammatory skin disease with a great impact in quality of life. However, there is little research about the impact of HS on sex life. The aims of this study are to describe the frequency of sexual distress (SD) in patients with HS and to explore potentially associated epidemiological and clinical factors. We conducted a cross-sectional study by means of a crowd-sourced online questionnaire hosted by the Spanish hidradenitis suppurativa patients\u2019 association (ASENDHI). Sexual distress (SD) was evaluated with a Numeric Rating Scale (NRS) for HS impact on sex life. A total of 393 participants answered the questionnaire. The mean NRS for HS impact on sex life was 7.24 (2.77) in women and 6.39 (3.44) in men (p &lt; 0.05). Variables significantly associated (p &lt; 0.05) with SD in the multiple linear regression model were sex, with a higher risk in females, the presence of active lesions in the groin and genitals and NRS for pain and unpleasant odor; being in a stable relationship was an important protector factor. Regarding these results, it seems that SD in HS patients is due, at least in part, to disease symptoms and active lesions in specific locations, emphasizing the importance of disease control with a proper treatment according to management guidelines. Women and single patients are more likely to suffer from sexual distress.<\/jats:p>","DOI":"10.3390\/jcm8040532","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T11:58:21Z","timestamp":1555588701000},"page":"532","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Sexual Distress in Patients with Hidradenitis Suppurativa: A Cross-Sectional Study"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7579-4931","authenticated-orcid":false,"given":"Carlos","family":"Cuenca-Barrales","sequence":"first","affiliation":[{"name":"Dermatology, Hospital Universitario San Cecilio, Avenida de la Investigaci\u00f3n s\/n, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0381-6174","authenticated-orcid":false,"given":"Ricardo","family":"Ruiz-Villaverde","sequence":"additional","affiliation":[{"name":"Dermatology, Hospital Universitario San Cecilio, Avenida de la Investigaci\u00f3n s\/n, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6882-2113","authenticated-orcid":false,"given":"Alejandro","family":"Molina-Leyva","sequence":"additional","affiliation":[{"name":"Dermatology, Hidradenitis Suppurativa Clinic, Hospital Universitario Virgen de las Nieves, Avenida de las Fuerzas Armadas 2, 18014 Granada, Spain"},{"name":"European Hidradenitis Suppurativa Foundation (EHSF), 06847 Dessau-Ro\u00dflau, Germany"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria Granada, 18016 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1056\/NEJMcp1014163","article-title":"Clinical practice. Hidradenitis suppurativa","volume":"366","author":"Jemec","year":"2012","journal-title":"N. Engl. J. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.2340\/00015555-0866","article-title":"Psychophysical aspects of hidradenitis suppurativa","volume":"90","author":"Matusiak","year":"2010","journal-title":"Acta Derm. Venereol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1468-3083.2012.04468.x","article-title":"Depression in patients with hidradenitis suppurativa","volume":"27","author":"Onderdijk","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/bjd.15280","article-title":"The burden of common skin diseases assessed with the EQ5D: A European multicentre study in 13 countries","volume":"176","author":"Balieva","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2340\/00015555-2815","article-title":"Clinical Characteristics of Pruritus and Pain in Patients with Hidradenitis Suppurativa","volume":"98","author":"Matusiak","year":"2018","journal-title":"Acta Derm. Venereol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s40257-017-0280-2","article-title":"Assessing Pruritus in Hidradenitis Suppurativa: A Cross-Sectional Study","volume":"18","author":"Vossen","year":"2017","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1590\/abd1806-4841.20153254","article-title":"Distribution pattern of psoriasis, anxiety and depression as possible causes of sexual dysfunction in patients with moderate to severe psoriasis","volume":"90","author":"Carrascosa","year":"2015","journal-title":"Anais Bras. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1080\/08952841.2017.1395539","article-title":"Quality of life and sexual function in postmenopausal women","volume":"30","author":"Nazarpour","year":"2018","journal-title":"J. Women Aging"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.maturitas.2016.09.013","article-title":"Female sexual dysfunction (FSD): Prevalence and impact on quality of life (QoL)","volume":"94","author":"Nappi","year":"2016","journal-title":"Maturitas"},{"key":"ref_10","first-page":"347","article-title":"Chronic illness and sexual functioning","volume":"67","author":"Nusbaum","year":"2003","journal-title":"Am. Fam. Physician"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1159\/000453355","article-title":"Quality of Life and Psychosocial Implications in Patients with Hidradenitis Suppurativa","volume":"232","author":"Kouris","year":"2016","journal-title":"Dermatology"},{"key":"ref_12","first-page":"743","article-title":"Depression is a frequent co-morbidity in patients with acne inversa","volume":"11","author":"Kurek","year":"2013","journal-title":"JDDG"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/jdv.12567","article-title":"Psychiatric comorbidities in 3207 patients with hidradenitis suppurativa","volume":"29","author":"Shavit","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jid.2017.09.008","article-title":"Increased Suicide Risk in Patients with Hidradenitis Suppurativa","volume":"138","author":"Thorlacius","year":"2018","journal-title":"J. Investig. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/bjd.14922","article-title":"A pilot study of unemployment in patients with hidradenitis suppurativa in Denmark","volume":"176","author":"Thorlacius","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.jaad.2009.09.021","article-title":"Hidradenitis suppurativa markedly decreases quality of life and professional activity","volume":"62","author":"Matusiak","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_17","unstructured":"ASENDHI [Internet] (2018, September 28). Madrid: ASENDHI. Available online: http:\/\/asendhi.org\/."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1111\/bjd.13502","article-title":"Hidradenitis suppurativa: A pilot study to determine the capability of patients to self-assess their Hurley stage","volume":"172","author":"Deckers","year":"2015","journal-title":"Br. J. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.3899\/jrheum.150595","article-title":"Patient\u2019s Global Assessment as an Outcome Measure for Psoriatic Arthritis in Clinical Practice: A Surrogate for Measuring Low Disease Activity?","volume":"42","author":"Lubrano","year":"2015","journal-title":"J. Rheumatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/jdv.12966","article-title":"European S1 guideline for the treatment of hidradenitis suppurativa\/acne inversa","volume":"29","author":"Zouboulis","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/bjd.12787","article-title":"The prevalence of inverse recurrent suppuration: A population-based study of possible hidradenitis suppurativa","volume":"170","author":"Vinding","year":"2014","journal-title":"Br. J. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.jaad.2008.06.020","article-title":"Prevalence and factors associated with hidradenitis suppurativa: Results from two case-control studies","volume":"59","author":"Revuz","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/bjd.16101","article-title":"Population-based Clinical Practice Research Datalink study using algorithm modelling to identify the true burden of hidradenitis suppurativa","volume":"178","author":"Ingram","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/jid.2012.255","article-title":"Incidence of hidradenitis suppurativa and associated factors: A population-based study of Olmsted County, Minnesota","volume":"133","author":"Vazquez","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/bjd.13864","article-title":"Overweight, diabetes and disease duration influence clinical severity in hidradenitis suppurativa-acne inversa: Evidence from the national Italian registry","volume":"174","author":"Bettoli","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jaad.2016.04.067","article-title":"Hidradenitis suppurativa (HS) is associated with low socioeconomic status (SES): A cross-sectional reference study","volume":"75","author":"Deckers","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jaad.2014.11.017","article-title":"Correlation of early-onset hidradenitis suppurativa with stronger genetic susceptibility and more widespread involvement","volume":"72","author":"Deckers","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jaad.2014.04.001","article-title":"Hidradenitis suppurativa: A retrospective study of 846 Dutch patients to identify factors associated with disease severity","volume":"71","author":"Schrader","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jaad.2011.10.024","article-title":"Profound disturbances of sexual health in patients with acne inversa","volume":"67","author":"Kurek","year":"2012","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/jdv.12845","article-title":"Sexual dysfunction in psoriasis: A systematic review","volume":"29","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.jsxm.2018.04.630","article-title":"Association Between Psoriasis and Erectile Dysfunction: A Meta-Analysis","volume":"15","author":"Wu","year":"2018","journal-title":"J. Sex. Med."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1111\/jsm.12119","article-title":"Assessment of female sexual function in patients with psoriasis","volume":"10","author":"Maaty","year":"2013","journal-title":"J. Sex. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1111\/jsm.12710","article-title":"Distribution pattern of psoriasis affects sexual function in moderate to severe psoriasis: A prospective case series study","volume":"11","year":"2014","journal-title":"J. Sex. Med."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1111\/bjd.14975","article-title":"Sexual health and quality of life are impaired in hidradenitis suppurativa: A multicentre cross-sectional study","volume":"176","author":"Janse","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s10508-007-9205-0","article-title":"Body concerns in and out of the bedroom: Implications for sexual pleasure and problems","volume":"36","author":"Sanchez","year":"2007","journal-title":"Arch. Sex. Behav."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/j.jaad.2015.07.045","article-title":"Pathophysiology of hidradenitis suppurativa: An update","volume":"73","author":"Prens","year":"2015","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/bjd.16261","article-title":"Tobacco smoking and hidradenitis suppurativa: Associated disease and an important modifiable risk factor","volume":"178","author":"Micheletti","year":"2018","journal-title":"Br. J. Dermatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1159\/000350056","article-title":"Cumulative life course impairment in other chronic or recurrent dermatologic diseases","volume":"44","author":"Ibler","year":"2013","journal-title":"Curr. Probl. Dermatol."},{"key":"ref_39","first-page":"42","article-title":"Psychosocial Impairment as a Possible Cause of Sexual Dysfunction among Young Men with Mild Androgenetic Alopecia: A Cross-sectional Crowdsourcing Web-based Study","volume":"24","year":"2016","journal-title":"Acta Dermatovenerol. Croat."}],"container-title":["Journal of Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/4\/532\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:46:20Z","timestamp":1760186780000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2077-0383\/8\/4\/532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,18]]},"references-count":39,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4]]}},"alternative-id":["jcm8040532"],"URL":"https:\/\/doi.org\/10.3390\/jcm8040532","relation":{},"ISSN":["2077-0383"],"issn-type":[{"value":"2077-0383","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,18]]}}}