{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T16:05:59Z","timestamp":1783181159949,"version":"3.54.6"},"reference-count":37,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T00:00:00Z","timestamp":1556236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Background: Acute myocardial infarction (AMI) survivors are at risk of major adverse cardiac events and their risk stratification is a prerequisite to tailored therapeutic approaches. Biomarkers could be of great utility in this setting. Methods: We sought to evaluate the utility of the combined assessment of Galectin 3 (Gal-3) and Galectin 3 binding protein (Gal-3bp) for post-AMI risk stratification in a large, consecutive population of AMI patients. The primary outcomes were: Recurrent angina\/AMI and all-cause mortality at 12 months after the index event. Results: In total, 469 patients were included. The median Gal-3bp was 9.1 \u03bcg\/mL (IQR 5.8\u201313.5 \u03bcg\/mL), while median Gal-3 was 9.8 ng\/mL (IQR 7.8\u201312.8 ng\/mL). During the 12 month follow-up, 34 patients died and 41 had angina pectoris\/reinfarction. Gal-3 was associated with all-cause mortality, while Gal-3bp correlated with the risk of angina\/myocardial infarction even when corrected for other significant covariates. The final multivariable model for mortality prediction included patients\u2019 age, left ventricular ejection fraction (LVEF), Gal-3, and renal function. The ROC curve estimated for this model has an area under the curve (AUC) of 0.84 (95%CI 0.78\u20130.9), which was similar to the area under the ROC curve obtained using the GRACE score 1-year mortality. Conclusions: The integrated assessment of Gal-3 and Gal-3bp could be helpful in risk stratification after AMI.<\/jats:p>","DOI":"10.3390\/jcm8050570","type":"journal-article","created":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T08:26:33Z","timestamp":1556267193000},"page":"570","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Galectin 3 and Galectin 3 Binding Protein Improve the Risk Stratification after Myocardial Infarction"],"prefix":"10.3390","volume":"8","author":[{"given":"Giulia","family":"Gagno","sequence":"first","affiliation":[{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria di Trieste and Department of Medical Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4618-7336","authenticated-orcid":false,"given":"Laura","family":"Padoan","sequence":"additional","affiliation":[{"name":"Sport and Exercise Medicine Division, Department of Medicine, University of Padova, 35122 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Stenner","sequence":"additional","affiliation":[{"name":"Unique Laboratory of ASUITs, Burlo, Gorizia and Monfalcone, Azienda Sanitaria Universitaria di Trieste, 34100 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2481-9964","authenticated-orcid":false,"given":"Alessandro","family":"Bele\u00f9","sequence":"additional","affiliation":[{"name":"Department of Radiology, G.B. Rossi Hospital, University of Verona, 37134 Verona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Ziberna","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2013IRCCS \u201cBurlo Garofolo\u201d Trieste and University of Trieste, 34100 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Hiche","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria di Trieste and Department of Medical Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Paldino","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria di Trieste and Department of Medical Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Barbati","sequence":"additional","affiliation":[{"name":"Biostatistics Unit, Department of Medical Surgical and Health Sciences, University of Trieste, 34100 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Biolo","sequence":"additional","affiliation":[{"name":"Unit of Clinica Medica Generale e Terapia Medica, Department of Medical Surgical and Health Sciences, University of Trieste, 34100 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8918-7622","authenticated-orcid":false,"given":"Nicola","family":"Fiotti","sequence":"additional","affiliation":[{"name":"Unit of Clinica Medica Generale e Terapia Medica, Department of Medical Surgical and Health Sciences, University of Trieste, 34100 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarcisio","family":"Not","sequence":"additional","affiliation":[{"name":"Institute for Maternal and Child Health\u2013IRCCS \u201cBurlo Garofolo\u201d Trieste and University of Trieste, 34100 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0679-2710","authenticated-orcid":false,"given":"Antonio Paolo","family":"Beltrami","sequence":"additional","affiliation":[{"name":"Department of Medicine (DAME), University of Udine, 33100 Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Sinagra","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria di Trieste and Department of Medical Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7711-9905","authenticated-orcid":false,"given":"Aneta","family":"Aleksova","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, Azienda Sanitaria Universitaria di Trieste and Department of Medical Surgical and Health Sciences, University of Trieste, 34129 Trieste, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,26]]},"reference":[{"key":"ref_1","unstructured":"(2018, July 26). 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