{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:38:03Z","timestamp":1760240283815,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T00:00:00Z","timestamp":1556323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Malapposition is a common finding in stent and scaffold thrombosis (ScT). Evidence from studies with prospective follow-up, however, is scarce. We hypothesized that incidental observations of strut malapposition might be predictive of late ScT during subsequent follow-up. One hundred ninety-seven patients were enrolled in a multicentre registry with prospective follow-up. Optical coherence tomography (OCT), performed in an elective setting, was available in all at 353 (0\u2013376) days after bioresorbable scaffold (BRS) implantation. Forty-four patients showed evidence of malapposition that was deemed not worthy of intervention. Malapposition was not associated with any clinical or procedural parameter except for a higher implantation pressure (p = 0.0008). OCT revealed that malapposition was associated with larger vessel size, less eccentricity (all p &lt; 0.01), and a tendency for more uncovered struts (p = 0.06). Late or very late ScT was recorded in seven of these patients 293 (38\u2013579) days after OCT. OCT-diagnosed malapposition was a predictor of late and very late scaffold thrombosis (p &lt; 0.001) that was independent of the timing of diagnosis. We provide evidence that an incidental finding of malapposition\u2014regardless of the timing of diagnosis of the malapposition\u2014during an elective exam is a predictor of late and very late ScT. Our data provide a rationale to consider prolonged dual antiplatelet therapy if strut malapposition is observed.<\/jats:p>","DOI":"10.3390\/jcm8050580","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T02:57:32Z","timestamp":1556506652000},"page":"580","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Incidental Finding of Strut Malapposition Is a Predictor of Late and Very Late Thrombosis in Coronary Bioresorbable Scaffolds"],"prefix":"10.3390","volume":"8","author":[{"given":"Niklas F.","family":"Boeder","sequence":"first","affiliation":[{"name":"Medical Clinic I, University Hospital of Giessen, Klinikstrasse 33, 35392 Giessen, Germany"},{"name":"Zentrum f\u00fcr Kardiologie, University Hospital Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany and German Center for Cardiac and Vascular Research (DZHK), Standort Rhein-Main"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Weissner","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Kardiologie, University Hospital Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany and German Center for Cardiac and Vascular Research (DZHK), Standort Rhein-Main"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Blachutzik","sequence":"additional","affiliation":[{"name":"Medical Clinic I, University Hospital of Giessen, Klinikstrasse 33, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Ullrich","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Kardiologie, University Hospital Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany and German Center for Cardiac and Vascular Research (DZHK), Standort Rhein-Main"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remzi","family":"Anadol","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Kardiologie, University Hospital Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany and German Center for Cardiac and Vascular Research (DZHK), Standort Rhein-Main"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Tr\u00f6bs","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Erlangen, Ulmenweg 18, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5503-4150","authenticated-orcid":false,"given":"Thomas","family":"M\u00fcnzel","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Kardiologie, University Hospital Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany and German Center for Cardiac and Vascular Research (DZHK), Standort Rhein-Main"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian W.","family":"Hamm","sequence":"additional","affiliation":[{"name":"Medical Clinic I, University Hospital of Giessen, Klinikstrasse 33, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8666-3731","authenticated-orcid":false,"given":"Jouke","family":"Dijkstra","sequence":"additional","affiliation":[{"name":"Department of Radiology, Leiden University Medical Center, P.O. Box 9600 (mailstop C2-S), 2300 Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Achenbach","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital of Erlangen, Ulmenweg 18, 91054 Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger M.","family":"Nef","sequence":"additional","affiliation":[{"name":"Medical Clinic I, University Hospital of Giessen, Klinikstrasse 33, 35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2917-6707","authenticated-orcid":false,"given":"Tommaso","family":"Gori","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Kardiologie, University Hospital Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany and German Center for Cardiac and Vascular Research (DZHK), Standort Rhein-Main"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1016\/j.jacc.2014.09.041","article-title":"Current status of bioresorbable scaffolds in the treatment of coronary artery disease","volume":"64","author":"Wiebe","year":"2014","journal-title":"J. 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