{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:06:59Z","timestamp":1785928019862,"version":"3.56.0"},"reference-count":32,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T00:00:00Z","timestamp":1557619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This work was supported by the Ministry of Education of Korea, the Korea government Ministry of Science and ICT, and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education","award":["2010-0020224, 2018R1A2A3074998, NRF-2018R1D1A1B07040370"],"award-info":[{"award-number":["2010-0020224, 2018R1A2A3074998, NRF-2018R1D1A1B07040370"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Asprosin, a novel hormone released from white adipose tissue, regulates hepatic glucose metabolism and is pathologically elevated in the presence of insulin resistance. It is unknown whether aerobic exercise training affects asprosin levels in type 1 diabetes mellitus (T1DM). The aim of this study was to determine whether (1) aerobic exercise training could decrease asprosin levels in the liver of streptozotocin (STZ)-induced diabetic rats and (2) the reduction in asprosin levels could induce asprosin-dependent downstream pathways. Five-week-old male Sprague\u2013Dawley rats were randomly divided into control, STZ-induced diabetes (STZ), and STZ with aerobic exercise training groups (n = 6\/group). T1DM was induced by a single dose of STZ (65 mg\/kg intraperitoneally (i.p.)). The exercise group was made to run on a treadmill for 60 min at a speed of 20 m\/min, 4 days per week for 8 weeks. Aerobic exercise training reduced the protein levels of asprosin, PKA, and TGF-\u03b2 but increased those of AMPK, Akt, PGC-1\u03b2, and MnSOD. These results suggest that aerobic exercise training affects hepatic asprosin-dependent PKA\/TGF-\u03b2 and AMPK downstream pathways in T1DM.<\/jats:p>","DOI":"10.3390\/jcm8050666","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T05:35:39Z","timestamp":1557725739000},"page":"666","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Aerobic Exercise Training Decreases Hepatic Asprosin in Diabetic Rats"],"prefix":"10.3390","volume":"8","author":[{"given":"Jeong Rim","family":"Ko","sequence":"first","affiliation":[{"name":"National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4377-5792","authenticated-orcid":false,"given":"Dae Yun","family":"Seo","sequence":"additional","affiliation":[{"name":"National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6568-2469","authenticated-orcid":false,"given":"Tae Nyun","family":"Kim","sequence":"additional","affiliation":[{"name":"National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se Hwan","family":"Park","sequence":"additional","affiliation":[{"name":"Institute of Sports Medicine, Hannam University, Daejeon 34430, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0451-4554","authenticated-orcid":false,"given":"Hyo-Bum","family":"Kwak","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Inha University, Incheon 22212, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Soo","family":"Ko","sequence":"additional","affiliation":[{"name":"National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung Doo","family":"Rhee","sequence":"additional","affiliation":[{"name":"National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Han","sequence":"additional","affiliation":[{"name":"National Research Laboratory for Mitochondrial Signaling, Department of Physiology, BK21 Plus Project Team, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF00374645","article-title":"The effects of streptozotocin diabetes on sodium-glucose transporter (SGLT1) expression and function in rat jejunal and ileal villus-attached enterocytes","volume":"430","author":"Debnam","year":"1995","journal-title":"Pflugers Arch."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0140-6736(06)68341-4","article-title":"Type 1 diabetes","volume":"367","author":"Daneman","year":"2006","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1464-5491.2009.02894.x","article-title":"Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: Therapeutic implications","volume":"27","author":"Gerich","year":"2010","journal-title":"Diabet. 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