{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:56:46Z","timestamp":1790639806998,"version":"4.1.0"},"reference-count":45,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T00:00:00Z","timestamp":1558828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JCM"],"abstract":"<jats:p>Objective: Rheumatoid arthritis and periodontal disease are associated together, but the effect of therapy provided for one disease to the second one remained under-investigated. This study investigated effect of infliximab therapy used to treat rheumatoid arthritis (RA) on various biomarkers of periodontal disease (PD) severity including serologies of Porphyromonas gingivalis and Prevotella intermedia and matrix metalloproteinase 3. Methods: Seventy nine RA patients were enrolled at the time to start infliximab therapy and the 28 joint disease activity score (DAS28), anti-cyclic citrullinated petides 2nd generation (anti-CCP2), anti-P. gingivalis antibody, and Matrix metalloproteinase 3 (MMP-3) were monitored before and at 6 months of infliximab therapy. Joint damage and severe periodontal disease were assessed at baseline. Anti-CCP2, anti-P. gingivalis antibody, and MMP-3 were determined by enzyme-linked immunosorbent assay (ELISA). Results: At baseline, anti-CCP2 titers were associated with anti-P. gingivalis lipopolysaccharide (LPS)-specific antibodies titers (p &lt; 0.05). Anti-P. gingivalis antibodies were not significantly correlated with clinical, biological, or destruction parameters of RA disease. At 6 months of infliximab therapy, MMP-3 level decreased (from 119 \u00b1 103 ng\/mL to 62.44 \u00b1 52 ng\/mL; p &lt; 0.0001), whereas P. gingivalis antibody levels remained at the same level. DAS28 and inflammation markers C-reactive protein (CRP) and Erythrocyte sedimentation rate (ESR) also decreased significantly during infliximab therapy (p &lt; 0.05) as anti-CCP2 levels (p &lt; 0.001). Only high MMP-3 level at baseline was associated with infliximab efficacy (p &lt; 0.01). Conclusion: MMP-3 level can be a useful marker of the efficacy of infliximab in RA patients. The treatment did not affect anti-P. gingivalis antibodies.<\/jats:p>","DOI":"10.3390\/jcm8050751","type":"journal-article","created":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T23:07:27Z","timestamp":1558912047000},"page":"751","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Infliximab Induced a Dissociated Response of Severe Periodontal Biomarkers in Rheumatoid Arthritis Patients"],"prefix":"10.3390","volume":"8","author":[{"given":"M\u00e9lanie","family":"Rinaudo-Gaujous","sequence":"first","affiliation":[{"name":"GIMAP EA3064, Laboratory of Immunology and Immunomonitoring, CIC CIE3 Inserm Vaccinology, H\u00f4pital Nord, CHU Saint-Etienne, 42270 Saint-Priest-en-Jarez, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Blasco-Baque","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Metabolic Diseases, CHU Rangueil, 31400 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Miossec","sequence":"additional","affiliation":[{"name":"Clinical Immunology Unit, Departments of Immunology and Rheumatology, H\u00f4pital Edouard Herriot, CHU Lyon, 69003 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Gaudin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, CHU Grenoble, 38130 \u00c9chirolles, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Farge","sequence":"additional","affiliation":[{"name":"Faculty of Odontology, University Lyon I., 69622 Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Roblin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, H\u00f4pital Nord, CHU Saint-Etienne, 42270 Saint-Priest-en-Jarez, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, H\u00f4pital Nord, CHU Saint-Etienne, 42055 Saint-Etienne, France"},{"name":"INSERM U1059, Universit\u00e9 de Lyon\u2013Universit\u00e9 Jean Monnet, 42023 Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Paul","sequence":"additional","affiliation":[{"name":"GIMAP EA3064, Laboratory of Immunology and Immunomonitoring, CIC CIE3 Inserm Vaccinology, H\u00f4pital Nord, CHU Saint-Etienne, 42270 Saint-Priest-en-Jarez, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1177-9497","authenticated-orcid":false,"given":"Hubert","family":"Marotte","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, H\u00f4pital Nord, CHU Saint-Etienne, 42055 Saint-Etienne, France"},{"name":"INSERM U1059, Universit\u00e9 de Lyon\u2013Universit\u00e9 Jean Monnet, 42023 Saint-Etienne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1136\/ard.2010.138461","article-title":"2010 rheumatoid arthritis classification criteria: An American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"69","author":"Aletaha","year":"2010","journal-title":"Ann. 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